Could CAR-T therapy calm Tough-to-Treat scleroderma?
NCT ID NCT06792344
First seen Jan 05, 2026 · Last updated Apr 30, 2026 · Updated 19 times
Summary
This early-stage trial tests whether a patient's own immune cells, modified to target CD19, can safely treat severe systemic sclerosis (scleroderma) that hasn't responded to standard drugs. About 12 children and adults will receive the CAR-T infusion and be monitored for changes in skin tightness and disease activity over 6 months. The goal is to control the disease, not cure it, since ongoing management may still be needed.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Hospital, Zhejiang University School of Medicine
RECRUITINGHangzhou, Zhejiang, 0571, China
Contact
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Children's Hospital, Zhejiang University School of Medicine
RECRUITINGHangzhou, Zhejiang, 310053, Christmas Island
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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