New shot could ease skin tightening in rare disease

NCT ID NCT06655155

Recruiting now Disease control Sponsor: argenx Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This study tests an experimental drug called efgartigimod PH20 SC in adults with systemic sclerosis, a disease that causes skin thickening and organ problems. About 81 participants will receive either the drug or a placebo as a shot under the skin for up to 48 weeks. Researchers will measure changes in skin thickness and check for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: efgartigimod PH20 SC (a drug given as a shot under the skin)
What this could lead to: If it works, this could point toward a new treatment to reduce skin thickening and other symptoms of systemic sclerosis.
What could go wrong: This is an early Phase 2 trial with only 81 people, so results may not apply to everyone. The drug may not improve symptoms or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC SCLEROSIS (SSC)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

AP-HP - Hôpital Cochin - Port-Royal, site Cochin
RECRUITING

Paris, 75014, France
Aprillus Asistencia e Investigacion
RECRUITING

Buenos Aires, C1046AAQ, Argentina
Arizona Arthritis and Rheumatology Associates
RECRUITING

Phoenix, Arizona, 85032-9306, United States
Auenlandklinik Bad Bramstedt GmbH
RECRUITING

Bad Bramstedt, 24576, Germany
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Azienda Ospedaliera Universitaria Luigi Vanvitelli
RECRUITING

Naples, 80131, Italy
BIOCINETIC Ltda
RECRUITING

Santiago, 8320000, Chile
C.H. Regional Reina Sofia
RECRUITING

Córdoba, 14004, Spain
CHU de Bordeaux - Hôpital Pellegrin
RECRUITING

Bordeaux, 33000, France
CHU de Lille - Hopital Claude Huriez
RECRUITING

Lille, 59000, France
CHU de Montpellier- Hôpital Saint Eloi
RECRUITING

Montpellier, 34090, France
CHU de Strasbourg - Hôpital de Hautepierre
RECRUITING

Marseille, 13274, France
Centro Integral Reumatologia SA de CV
RECRUITING

Guadalajara, 44160, Mexico
Centro de Investigaciones Clinicas UC (CICUC)
RECRUITING

Santiago, 8330034, Chile

Contact Email: •••••@•••••
Centro de Investigaciones Médicas Tucumán
RECRUITING

San Miguel de Tucumán, T4000IKJ, Argentina
Centro de Investigaciones Reumatológicas
RECRUITING

San Miguel de Tucumán, T4000IAP, Argentina
Centro de Investigación y Tratamiento Reumatológico S.C
RECRUITING

Mexico City, 11850, Mexico
Centro de especialidades médicas Vanguardia
RECRUITING

Temuco, 4810345, Chile
Chapel Allerton Hospital
RECRUITING

Leeds, LS7 4SA, United Kingdom
Clinical Hospital Centre Osijek
RECRUITING

Osijek, 31000, Croatia
Clínica Mayo de U.M.C.B. S.R.L
RECRUITING

San Miguel de Tucumán, T4000IHE, Argentina
Consultorios Médicos Dr. Doreski - Fundacion Respirar
RECRUITING

Buenos Aires, C1426ABP, Argentina
Corporacio Sanitaria Parc Tauli
RECRUITING

Sabadell, 08208, Spain
DelRicht Research, LLC
RECRUITING

New Orleans, Louisiana, 70112, United States
Diagnostic Consultative Center Convex EOOD
RECRUITING

Sofia, 1680, Bulgaria
Dr I Cantacuzino Clinical Hospital
RECRUITING

Bucharest, 20475, Romania
Euromedica Kianous Stavros
RECRUITING

Thessaloniki, 546 36, Greece
Fondazione Policlinico Universitario A. Gemelli IRCCS
RECRUITING

Roma, 00168, Italy
Fondazione Policlinico Universitario Campus Bio-Medico
RECRUITING

Roma, 128, Italy
General Hospital Zadar
RECRUITING

Zadar, 23000, Croatia
Hospital Del Mar
RECRUITING

Barcelona, 8023, Spain
Hospital General de Agudos Dr. José María Ramos Mejia
RECRUITING

Buenos Aires, Argentina
Hospital of Lithuanian University of Health Sciences Kauno klinikos
RECRUITING

Kaunas, 50161, Lithuania
IRCCS Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
IRIS Research and Development LLC
RECRUITING

Plantation, Florida, 33324, United States
Institute of Rheumatology - PPDS
RECRUITING

Belgrade, 11000, Serbia
Instituto de Investigación Clínica TyT
RECRUITING

Buenos Aires, C1405BFN, Argentina
Johns Hopkins Asthma and Allergy Center
RECRUITING

Baltimore, Maryland, 21224, United States
Kantonsspital St. Gallen
RECRUITING

Sankt Gallen, 9000, Switzerland
Klaipeda Hospital, Affiliate of Klaipeda University Hospital
RECRUITING

Klaipėda, LT-92288, Lithuania
Leids Universitair Medisch Centrum
RECRUITING

Leiden, 2333 ZA, Netherlands
Luton and Dunstable University Hospital
RECRUITING

Luton, LU4 0DZ, United Kingdom
MICS Centrum Medyczne Warszawa
RECRUITING

Warsaw, 00-874, Poland
Malopolskie Badania Kliniczne
RECRUITING

Krakow, 30-002, Poland
Mediadvance Clinical S.A.P.I. de C.V.
RECRUITING

Chihuahua City, 31203, Mexico

Contact Email: •••••@•••••
Medical Care and Research S.A. de C.V.
RECRUITING

Mérida, 97070, Mexico
Medical Center Artmed OOD
RECRUITING

Plovdiv, 4002, Bulgaria
Military Medical Academy
RECRUITING

Belgrade, 11152, Serbia
Mühlenkreiskliniken - Johannes Wesling Klinikum Minden
RECRUITING

Minden, 32429, Germany
Niepubliczny Zaklad Opieki Zdrowotnej Biogenes
RECRUITING

Wroclaw, 53-224, Poland
Olympion General Clinic
RECRUITING

Pátrai, 264 43, Greece
Ospedale San Raffaele S.r.l.
RECRUITING

Milan, 20132, Italy
Pecsi Tudomanyegyetem, Klinika Kozpont, Bor, Nemikortani es Onkodermatologiai Klinika
RECRUITING

Pécs, 7632, Hungary
Perelman Center for Advanced Medicine
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Revmatologicky Ustav
RECRUITING

Prague, 140 59, Czechia
Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Royal Free Hospital
RECRUITING

London, NW3 2QG, United Kingdom
Sanatorio Allende S.A.
RECRUITING

Córdoba, 5000, Argentina
Sf.Maria Clinical Hospital
RECRUITING

Bucharest, 11172, Romania
The Alliance Medical Sciences Campus
RECRUITING

San Juan, 00936, Puerto Rico
Thomas Jefferson University
RECRUITING

Columbia, Maryland, 21044, United States
Twoja Przychodnia NCM
RECRUITING

Nowa Sól, 67-100, Poland
UCLA Ronald Reagan University of California Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90095, United States
ULS de Gaia/Espinho, EPE - Unidade I
RECRUITING

Vila Nova de Gaia, 4434-502, Portugal
ULS de Lisboa Ocidental, EPE - Hospital Egas Moniz
RECRUITING

Lisbon, 1349-019, Portugal
ULS de Santa Maria,EPE - Hospital de Santa Maria
RECRUITING

Lisbon, 1649-035, Portugal
UZ Brussel
RECRUITING

Jette, 1090, Belgium
UZ Gent
RECRUITING

Ghent, 9000, Belgium
University General Hospital of Patras
RECRUITING

Pátrai, 265 04, Greece
University Hospital of Split
RECRUITING

Split, 21000, Croatia
University of Illinois Health Outpatient Care Center
RECRUITING

Chicago, Illinois, 60612, United States
University of Michigan Hospital
RECRUITING

Ann Arbor, Michigan, 48109, United States

Contact Email: •••••@•••••
Universitätsklinikum Schleswig-Holstein - Campus Lübeck
RECRUITING

Lübeck, 23562, Germany
Universitätsklinikum Tübingen
RECRUITING

Tübingen, 72076, Germany
Universitätsspital Zürich
RECRUITING

Zurich, 8090, Switzerland
Zespol Poradni Specjalistycznych REUMED
RECRUITING

Lublin, 20-607, Poland

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