SYSTEMIC SCLEROSIS (SSC)

This early-stage trial tests a new drug called HN2302, a type of CAR-T cell therapy made inside the body, for people with autoimmune diseases like lupus and scleroderma. The study will enroll 12 adults to check safety and see if it works. Researchers will monitor side effects and…

This early-phase trial will test BCT301, a type of immune cell made from stem cells, in 10 people with severe autoimmune diseases like lupus and scleroderma. Participants receive a single infusion of these cells after a short course of chemotherapy. The main goal is to check safe…

This early-phase trial will test the safety and tolerability of a new drug, cizutamig, in 10 people with systemic sclerosis, a condition that causes hardening of the skin and internal organs. Participants must have a certain severity of skin thickening and have not responded well…

This early-stage trial tests a stem cell injection (HS_SW01) in 21 adults with systemic sclerosis, a disease where the immune system attacks the body, causing skin hardening and organ damage. The main goal is to see if the treatment is safe and tolerable. Researchers will also ch…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This early-phase study tests a new drug called GB261 in 10 adults with systemic sclerosis, a disease that causes skin hardening and organ damage. The main goal is to check safety and how the body handles the drug. It is not a cure but aims to control the disease.

This study will measure a blood protein called FAP, which is linked to tissue scarring and inflammation, in people with rheumatoid arthritis or systemic sclerosis and in healthy volunteers. Researchers want to see if FAP levels match up with standard disease activity scores and l…

This study will take blood samples from 16 people—some with severe scleroderma, some with mild forms, and their healthy relatives—to create stem cells in the lab. These stem cells will be turned into different cell types (like heart, skin, and immune cells) to study how the disea…

This study will test if blocking a protein called TL1A can reverse skin scarring in systemic sclerosis, a rare autoimmune disease. Researchers will take blood and skin samples from 10 patients with early diffuse scleroderma and 10 healthy people. They will treat the samples in th…

This study will use a high-tech blood test (mass spectrometry) to look at different immune cells in 500 people with various autoimmune diseases like lupus, rheumatoid arthritis, and Sjogren's syndrome, plus healthy volunteers. The goal is to find patterns that could help doctors …