SMOKING

This study looks at whether e-cigarettes or nicotine pouches can help adults who smoke cigarettes cut down. About 256 people will be given one of these products to use for 4 weeks, with different flavors and nicotine levels. Researchers will track how many cigarettes they smoke a…

This study tests whether personalized stop-smoking plans help cancer patients quit better than standard care. Researchers use each patient's health history, genes, and lab results to recommend the best medication. The goal is to see if more patients take and stick with quitting a…

This study tests a program called QuitAid, where pharmacists coach rural smokers on quitting. About 768 people from Virginia, Tennessee, Kentucky, and North Carolina will join. All get nicotine patches, and some also get extra support like text messages, phone counseling, or more…

This study tests whether giving people with HIV a choice of nicotine replacement products (like e-cigarettes, nicotine pouches, or patches) helps them stop smoking tobacco cigarettes. About 972 smokers from the Swiss HIV Cohort Study will be randomly assigned to receive either us…

This study tests whether adding financial coaching to standard smoking cessation counseling helps people with low income quit smoking more successfully. About 600 smokers in New York City who smoke at least 5 cigarettes daily and have low income will be randomly assigned to eithe…

This study tests whether giving smokers a personalized quit plan based on their genes, health history, and biomarkers helps them stop smoking more than standard care. About 850 adult smokers and their doctors will take part. The goal is to see if this approach increases the use o…

This study tests a medicine called brenipatide to see if it can help adults who have recently quit smoking avoid starting again. About 222 participants will receive either the drug or a placebo for 24 weeks, and researchers will track who stays smoke-free using carbon monoxide te…

This study looks at whether adult smokers who switch to a heated tobacco device (like a prototype called TP18) have lower levels of certain harmful chemicals in their body compared to those who keep smoking regular cigarettes. About 108 smokers will be monitored for 5 days in a c…

This study tests a program that helps smokers with cancer quit smoking. About 1,448 participants will either get a personalized quit plan with supportive text messages or just brief advice. The goal is to see if the app-based approach leads to more people successfully quitting, c…

This study tests a 24-week program called Black Impact to improve heart health and reduce stress in Black men. About 340 Black men with below-ideal heart health will either join the program right away or be placed on a waitlist. The program includes weekly exercise, health educat…

This study tests a program called Inspire HER for Black women aged 30-79 with heart, kidney, and metabolic health issues. The program offers health education, physical activity, and social support to help lower heart disease risk. Researchers will see if the program is practical …

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system (THS) experience fewer symptoms like coughing and shortness of breath, and see improvements in lung function and walking ability. The study will comp…

This study tests whether using mobile health (mHealth) tools helps find oral cancer and pre-cancer earlier than traditional screening methods. Over 5,000 adults in rural Varanasi, India, who smoke, chew tobacco, or drink alcohol will be screened. The goal is to improve early dete…

This study is testing whether low-dose CT scans can detect lung cancer early in over 6,600 high-risk people in Taiwan. Participants include heavy smokers who have quit, people with a family history of lung cancer, and those exposed to air pollution or other risks at work or home.…

This study is testing a new chatbot that uses motivational interviewing to help people stop smoking. The chatbot will provide education, support, and a personalized quit plan. The study will enroll 440 adult smokers who are patients at a primary care clinic and follow them for 6 …

This study tests whether a smartphone app that uses augmented reality (AR) can help people stop smoking when used alongside standard quitline counseling. The app shows smoking-related cues to help users practice resisting cravings. About 3600 adult daily smokers will take part. T…

This study tests if Emotional Freedom Techniques (EFT), a type of tapping therapy, can help smokers who have failed standard quit programs. About 40 participants who struggle with cravings, anxiety, or low confidence will receive EFT. Researchers will check quit rates and symptom…

This study tests a new online program that teaches coping skills to help smokers quit and manage stress, anxiety, and depression. About 60 adult smokers in Hong Kong who want to stop smoking will try the program or get standard support. Researchers will check if the program is ea…

This study looks at whether a daily dose of kava can help smokers who want to quit. Researchers will check if kava makes it easier to stop smoking, reduces stress, and improves sleep. About 76 adult smokers will take kava and report their progress over several months.

This study looks at whether special chest exercises can improve lung function and exercise ability in university students who smoke. Researchers will compare two types of exercises in 30 students aged 18-24 who have smoked for at least 2 years. The goal is to see if these exercis…

This study tests whether a non-invasive brain stimulation technique called rTMS can help daily smokers quit. Researchers want to see if offering this treatment in a nicotine addiction clinic is practical and acceptable. About 40 participants will receive daily rTMS sessions for 3…

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. About 10…

This study looks at how differences in brain activity when people see emotional images might affect how well a brain stimulation treatment (rTMS) works for smokers. Researchers will enroll 100 adults aged 21 to 60 who smoke at least 5 cigarettes a day. The goal is to understand w…

This study explores how everyday environments influence smoking relapse. Researchers will use smartphone photos and artificial intelligence to analyze the surroundings of 500 adults trying to quit smoking. The goal is to identify environmental triggers and develop tools to help p…

This study collects blood, airway, and urine samples from up to 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. The goal is to establish normal ranges and learn how gene changes in airway cells may lead to disease. Participants must be 18 …

This study tests a new way to help smokers in rural areas who are not yet ready to quit. Paramedics will refer participants to a text-message program designed to motivate them to stop smoking. The goal is to see if this approach can reach more people and help them eventually quit…

This study looks at brain activity in smokers trying to quit, to understand what leads to a lapse (smoking again). Researchers will use MRI scans to track changes in brain patterns and mood just before a lapse happens. The goal is to find early warning signs that could help preve…

This study looks at whether giving cancer patients an indoor air quality monitor can help them keep their homes smoke-free. Ten patients who smoke and are already in a tobacco treatment program will use the monitor for two weeks. The goal is to see if the device is easy to use an…

This study looks at whether the flavor of e-cigarettes helps smokers switch from regular cigarettes. About 210 adult smokers who have tried to quit before will be given fruit, tobacco, or menthol flavored e-cigarettes for six weeks. Researchers will track how many cigarettes they…

This study looks at how gum health and smoking influence certain inflammatory proteins (inflammasomes) in saliva. Researchers will compare levels of these proteins in people with healthy gums, those with gum disease, and smokers. The goal is to see if these proteins can help diag…

This study looks at how addictive five new oral nicotine products are. About 40 healthy smokers, aged 21 to 60, will use the products in a clinic and report their feelings while researchers measure nicotine levels in their blood. The goal is to understand the products' abuse pote…