SCHIZOAFFECTIVE DISORDER

This early-stage study tested a long-acting injectable form of the drug lumateperone in 52 adults with stable schizophrenia or schizoaffective disorder. Researchers gave a single shot and monitored how the drug moved through the body, as well as any side effects. The goal was to …

This study tested whether delivering coordinated specialty care (CSC) via telehealth works as well as standard in-person care for young people (ages 16–35) with early psychosis. Over 12 months, researchers tracked hospitalizations and engagement in 74 participants. The goal was t…

This study tested a 'Joint Crisis Plan' (also called an SOS Plan) for people with schizophrenia or schizoaffective disorder. The plan is created together by the patient, their family, and their healthcare team to guide care during a crisis. The goal was to see if having this plan…

This study looked at how well a combination of two antipsychotic medications (Abilify Maintena and Rexulti) works for people with schizophrenia in everyday life. Six adults took part, and researchers tracked changes in their symptoms, anxiety, and depression over six months. The …

This study tested whether adding a medication to a computer-based cognitive training program could improve thinking and daily function in people with schizophrenia or schizoaffective disorder. 68 adults completed 30 sessions of targeted cognitive training while some also received…

This study tested whether a smartphone app designed for people with serious mental illness can help them quit smoking better than standard methods. Researchers enrolled 343 adults with conditions like bipolar disorder or schizophrenia who wanted to quit. Participants used either …

This study tested whether mindfulness training can prevent relapse in people with psychosis. 152 participants who were in remission were randomly assigned to either mindfulness training or standard education. Researchers tracked them for 12 months to see who had a relapse.

This study tested whether low-intensity transcranial ultrasound stimulation (TUS) can ease negative symptoms of schizophrenia, such as lack of motivation and social withdrawal. 78 adults with stable schizophrenia received either real or sham ultrasound over the left prefrontal co…

This Phase 3 trial tested a sublingual film containing dexmedetomidine (BXCL501) to quickly reduce agitation in 380 adults with schizophrenia or related disorders. Participants received either the drug or a placebo film, and researchers measured changes in agitation symptoms over…

This study tested whether luteolin, a natural supplement found in foods like celery and chamomile tea, can improve symptoms in people with schizophrenia or schizoaffective disorder. 85 clinically stable adults took either luteolin or a placebo for 12 weeks while continuing their …

This study looked at whether adding the drug memantine to a computer-based cognitive training program could improve thinking and daily function in people with schizophrenia or schizoaffective disorder. 62 adults took part in a double-blind trial where some received memantine and …

This early-stage study tested the safety and how the body processes lumateperone in 26 teenagers aged 13 to 17 with schizophrenia or schizoaffective disorder. Participants took either 28 mg or 42 mg of the drug by mouth. The goal was to check for side effects and measure drug lev…

This study tested a visual training program for 79 adults with schizophrenia or schizoaffective disorder. The program aimed to improve two visual skills often impaired in these conditions: seeing contrast and organizing visual information. Participants completed different trainin…

This study looked at how well valbenazine works for tardive dyskinesia, a condition causing uncontrollable movements often linked to psychiatric medications. 59 adults with schizophrenia, bipolar disorder, or depression took valbenazine for up to 24 weeks. Researchers measured ch…

This study tested an investigational medication called BXCL501 for calming agitation episodes in people with schizophrenia or bipolar disorder. The medication was designed to be taken at home. 452 adults took part, and the drug was compared to a placebo (a dummy pill). The goal w…

This study looked at how dopamine receptors in the brain work in people with schizophrenia compared to healthy volunteers. Researchers used special PET and MRI scans to measure two types of dopamine receptors. The goal was to better understand what causes schizophrenia, which cou…

This study tested two types of brain stimulation (TMS) in 90 people who smoke, half with schizophrenia and half without. The goal was to see if TMS could change brain connections and reduce nicotine cravings. Participants completed thinking tasks and reported their cravings befor…

This study looked at how people aged 15 to 45 with early psychosis process information about their surroundings, compared to healthy young adults. Participants completed computer tasks while their brain activity was measured using EEG and MRI. The goal was to better understand br…

This study looked at how people aged 15-45 with early psychosis process information about their surroundings, called state representation. Researchers tested two types of cognitive training and measured changes in thinking and brain activity using computer tasks and scans. The go…

This study looked at how a supplement called N-acetylcysteine (NAC) affects brain chemicals and thinking in 88 adults with schizophrenia or related disorders. Participants took tryptophan to raise a brain chemical called kynurenic acid, then had cognitive tests and brain scans. T…

This early-stage study tested a new drug called MK-8189 in 55 people, including healthy volunteers and those with schizophrenia. The main goal was to see if the drug is safe and how it behaves in the body. Researchers measured drug levels and side effects, but this study did not …

This study tested whether a smartphone app could help veterans with serious mental illnesses like schizophrenia and bipolar disorder track their own symptoms. 87 veterans used the app to monitor their activity, sleep, and social interactions. The goal was to see if this data coul…

This study tested a program called Collaborative Decision Skills Training (CDST) to help veterans with serious mental illness (like schizophrenia or major depression with psychosis) work more closely with their doctors in making treatment decisions. The program involved eight wee…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study tested a program called NAVIGATE, which provides coordinated care for youth and young adults (ages 14-35) who have had a first episode of psychosis. The goal was to see if NAVIGATE helps improve recovery, reduce hospital stays, and lower healthcare costs compared to st…

This study looked at how people aged 18-30 with early psychosis process information about their surroundings, compared to those without a psychiatric diagnosis. Participants completed computer-based tasks and cognitive training. The goal was to better understand thinking patterns…

This study tested whether patients with schizophrenia or schizoaffective disorder could gain better insight into their illness by watching a video of themselves recorded during an acute episode. 60 hospitalized patients were randomly assigned to either watch the video after stabi…

This study tested whether sending text message reminders helps young people (ages 14-35) with psychosis attend their first appointment at an early psychosis clinic after being seen in the emergency room. Researchers enrolled 186 participants and tracked who showed up. The goal wa…

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study tested whether customizing cognitive training based on a person's early auditory processing ability improves thinking and daily function in people with schizophrenia or schizoaffective disorder. 194 participants were grouped by their auditory processing skill and then …