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Brain chemistry experiment seeks clues in schizophrenia

NCT ID NCT04013555

First seen Feb 11, 2026 · Last updated Jun 18, 2026 · Updated 23 times

Summary

This study looked at how a supplement called N-acetylcysteine (NAC) affects brain chemicals and thinking in 88 adults with schizophrenia or related disorders. Participants took tryptophan to raise a brain chemical called kynurenic acid, then had cognitive tests and brain scans. The goal was to see if NAC could block certain brain changes and improve memory.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Maryland Psychiatric Research Center (MPRC) ; the Treatment Research Program (TRP)

    Catonsville, Maryland, 21228, United States

Conditions

The condition(s) this trial relates to.

Psychotic Disorders schizoaffective disorder schizophrenia schizophreniform disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.