Sarcopenia

This trial tests whether Shanyu pill, a traditional Chinese herbal supplement made from yam, Atractylodes, and ginseng, can help older adults with sarcopenia, a condition marked by progressive muscle loss and weakness. Researchers will give 192 participants either the pill or a p…

This trial investigates whether combining neuromuscular electrical stimulation (NMES) with therapeutic ultrasound can help stroke patients who also have sarcopenia—a condition of low muscle mass and strength. Participants receive four weeks of daily therapy, and researchers measu…

This study tests a 12-week resistance exercise program designed to help older adults with sarcopenia (age-related muscle loss). The program uses behavior change techniques like education, rewards, and reminders to keep participants on track. One hundred community-dwelling adults …

This study tests whether starting physical therapy, electric muscle stimulation, and high-protein supplements early in the ICU can prevent the muscle loss, weakness, and mental decline known as post-intensive care syndrome (PICS). The trial enrolls adults aged 45 and older who ar…

This study tests whether adding creatine and HMB supplements to a supervised exercise program can improve physical function, muscle mass, thinking skills, and quality of life in frail older adults living in nursing homes. Fifty people aged 65 and older are taking part, receiving …

This study examines whether placing a feeding tube before chemotherapy helps prevent muscle loss in people with advanced esophageal cancer. About 60 adults receiving treatment with a goal to cure will be followed. Researchers will compare muscle mass at diagnosis, before surgery,…

This program offers expanded access to IMM01-STEM, an experimental treatment for sarcopenic obesity—a condition combining muscle loss and obesity. It is for patients who cannot join ongoing clinical trials due to location, eligibility, or other reasons. Participants receive weekl…

This study tests whether giving a special nutrient mixture (Olimel N12) during hemodialysis can help prevent muscle loss and improve quality of life in people with end-stage kidney disease. About 166 patients will receive either the nutrient infusion or a simple glucose solution …

This study looks at whether 12 months of high-intensity strength training can reduce falls in people aged 80 and older who have sarcopenia (age-related muscle loss). About 241 older adults living at home or in independent senior housing took part. The goal is to see if regular, p…

This study tests whether taking branched-chain amino acid (BCAA) supplements for 24 weeks can help people with liver cirrhosis who have low muscle mass (sarcopenia) regain muscle and improve strength. About 86 adults aged 18–85 will be randomly assigned to receive either BCAA or …

This study tests whether very short, AI-made videos (under 2 minutes) can help 180 older adults with sarcopenia (muscle loss) follow diet and exercise advice and reduce depression. Participants watch these nano-learning videos at home. The goal is to see if this simple approach i…

This study looks at 80 people with heart failure to find better ways to diagnose sarcopenia, a condition where muscles weaken and shrink. Researchers will use body scans, blood tests, and simple physical tests like walking speed and grip strength. The goal is to catch muscle loss…

This study looks at whether eating special biscuits made with pea protein and taking vitamin D can help prevent sarcopenia—the age-related loss of muscle mass and strength. Researchers will recruit 74 adults aged 65-80 with early signs of muscle loss. For 12 weeks, half will eat …

This study tests a digital therapeutic device (exoDTx) – a mobile app that guides personalized resistance exercises at home – to see if it can improve muscle strength in people with sarcopenia (age-related muscle loss). 130 participants will either use the app for 12 weeks or rec…

This pilot study tests whether taking a daily polyphenol supplement (from red leaf lettuce) alongside a 12-week exercise program can improve physical performance in adults over 60. The main goal is to see if the study is feasible—can people stick with it? Researchers will also me…

This study tests whether nicotinamide riboside (NR), a form of vitamin B3, can improve muscle strength, endurance, and walking speed in older veterans aged 65-85. Participants take NR or a placebo daily for several weeks and undergo exercise tests and muscle biopsies. The goal is…

This study looks at whether a 12-week program of functional task training (like standing up, walking, and carrying objects) can improve muscle strength and daily function in older adults with sarcopenia. 30 people aged 60 and older will be randomly assigned to different exercise …

This study tests whether a group exercise program shown on TVs during hemodialysis is safe and doable for people with chronic kidney failure. About 45 adults will follow along with exercise videos while receiving dialysis. The goal is to see if this approach can help fight muscle…

This study tests whether a 12-week exercise program done during dialysis can improve muscle oxygen levels and dialysis quality in kidney patients who also have muscle loss (sarcopenia). About 40 patients will either exercise on a bike and do resistance moves during their first tw…

Falls are a leading cause of injury in older adults. This study examines whether taking many medications, the side effects those medications have on memory and balance, and age-related muscle loss are linked to fall risk. Researchers will enroll adults aged 65 and older who visit…

This study examines whether women with primary Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth, also experience muscle loss, a condition called sarcopenia. Researchers will measure muscle strength, muscle mass, and physical performance in 120 participants…

This study explores whether a new type of resistance exercise is practical and safe for people with low bone mass, including those with osteopenia, osteoporosis, or sarcopenia. Over two months, one group performs progressive muscle-strengthening exercises while a control group co…

This study uses two advanced MRI techniques to measure muscle health in heart failure patients with and without sarcopenia (age-related muscle loss). Researchers will scan 70 participants to compare muscle composition and energy recovery. The goal is to find better ways to detect…

This study examines whether the COVID-19 pandemic increased frailty and muscle loss (sarcopenia) in people waiting for a liver transplant. Researchers will compare data from 208 patients assessed before and during the pandemic. The goal is to understand how the pandemic affected …

This study aimed to see if a 6-month nutrition plan could improve weight and strength in malnourished older adults compared to standard hospital care. It was designed for people aged 65 and older in Italian hospitals. However, the study was withdrawn before enrolling any particip…

This study measures how much force leg muscles can produce and how they use oxygen in people with stroke or sarcopenia (age-related muscle loss). Researchers will test hip, knee, and ankle strength at different angles and speeds. The goal is to gather data that could help design …

This study tracks 20 women with breast cancer to see if radiotherapy causes muscle loss outside the treated area and how it relates to fatigue. Participants complete fatigue questionnaires and get CT scans at four time points: start, end, and 1 and 3 months after treatment. The g…

This study aims to improve how we detect and treat sarcopenia—age-related muscle loss that can lead to frailty and disability. Researchers will use artificial intelligence to analyze data from body scans, strength tests, and wearable sensors to identify people at risk early. Then…

This study looks at whether common osteoporosis medications also improve muscle health in adults aged 65 and older. Researchers will measure changes in muscle mass, strength, and walking speed over time. The goal is to better understand the link between bone and muscle health in …

This study looks at whether having low muscle mass (sarcopenia) before lung cancer surgery affects how well patients recover. Researchers will follow 400 older adults having lung cancer surgery to see if sarcopenia is linked to survival and other outcomes. The goal is to find out…

This study follows 317 adults with type 2 diabetes who were first examined between 2019 and 2023. Researchers will repeat advanced liver scans, blood tests, and body composition measurements to see how liver fat and scarring change over time. The goal is to find out who is most a…

This study looks at how often muscle loss (sarcopenia) happens in adults who need a breathing machine in the ICU for more than 48 hours. Researchers will measure muscle health using simple tests and ultrasound. The goal is to understand how common this problem is and how it chang…

This study looks at how well muscle strength tests work for people with chronic kidney disease. It also tests if a supervised online exercise program is helpful and safe. 50 adults with kidney disease (on dialysis or with a transplant) will take part.

This study looks at 200 adults with solid tumors who are getting chemotherapy. Researchers will compare four different checklists (PG-SGA, MUST, Nutriscore, and GLIM criteria) to see which best identifies malnutrition and muscle loss. The goal is to find the most reliable tool so…

This study looks at how muscle loss (sarcopenia) affects people with chronic kidney disease (CKD) compared to healthy individuals. Researchers will measure body composition and muscle function in 80 participants. The goal is to better understand when and how muscle loss happens i…