RENAL CANCER

This study tests whether giving two drugs (pembrolizumab and axitinib) before surgery can shrink tumor clots in the main vein (inferior vena cava) for people with kidney cancer. About 17 adults with clear cell kidney cancer and a vein clot will receive the drugs for 12 weeks, the…

This early-phase study tests a new drug called NXP900 in about 140 adults with advanced solid tumors (like lung, kidney, or mesothelioma) that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors…

This early-phase trial tests a new drug called MDX2001 in about 285 adults with advanced solid tumors (cancers that have spread). The main goals are to check the drug's safety and find the right dose. Researchers will also see if it shrinks tumors. This is not a cure, but it may …

This study looks at using a special type of radiation (SBRT) to treat kidney cancer in people who cannot have surgery due to health risks or personal choice. The treatment delivers high doses of radiation in just a few sessions, is non-invasive, and does not require anesthesia or…

This study tests a new surgical technique for removing small kidney tumors (up to 7 cm) using a robot, without clamping the kidney's blood supply or using stitches. The goal is to preserve as much healthy kidney function as possible. About 190 adults aged 18-80 will participate, …

This study tests a new drug (BL-B01D1) combined with a standard targeted therapy (TKI), with or without an immunotherapy (pembrolizumab), in 260 adults with advanced kidney cancer that has spread. The goal is to see if these combinations shrink tumors and are safe. Participants m…

This study tests a new medicine, PF-08634404, in adults with advanced kidney cancer that has spread. The goal is to see if it is safe and can shrink tumors when given alone or with other cancer drugs. About 224 participants will receive the drug through an IV. This is an early-ph…

This study is testing a new type of radiation therapy called SMART, which uses MRI scans to guide treatment in real time. It includes up to 397 adults with various cancers like pancreas, lung, or prostate cancer. The goal is to see if this approach is safe and improves tumor cont…

This study aims to see if a special PET scan (68Ga-PSMA) is better than standard CT scans at finding where kidney cancer has spread in the body. About 300 adults with advanced kidney cancer will get both scans, and doctors will compare the results. If the PET scan proves more acc…

This study tests a new type of PET/CT scan that looks for a protein called CD70 on cancer cells. It aims to better detect kidney cancer, lymphoma, and nasopharyngeal cancer in 300 adults. The scan may help doctors see tumors more clearly and guide treatment decisions.

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This study tests if a spinal injection of pain medicine before robotic kidney or ureter surgery helps patients feel better the day after compared to an IV pain medicine given during surgery. About 220 adults having robotic upper urinary tract surgery will be randomly assigned to …

This study tests whether non-steroidal anti-inflammatory drugs (NSAIDs) can effectively control pain after robotic kidney surgery for cancer, reducing the need for stronger opioid painkillers. About 110 adults undergoing this surgery will be randomly assigned to receive either NS…

This study tests a new type of CT scan that takes pictures during cancer treatments like embolization or ablation for liver and kidney tumors. The goal is to see if the new method provides clearer images and helps doctors guide procedures more precisely. About 30 adults with tumo…

This study collects extra blood, tissue, and urine samples from children and adults with childhood cancers like leukemia and brain tumors. The goal is to create a large repository for researchers to study the biology of these cancers. No extra procedures are needed—samples are ta…

This study looks at how hospitals handle patients who are admitted with blood in their urine (hematuria). Researchers will track about 1,050 adults to see differences in care, how long they stay, and what happens after. The goal is to create better guidelines and improve the pati…

This study aims to find the genetic causes of certain blood cancers like lymphoma, leukemia, and multiple myeloma. Researchers will collect DNA and blood samples from people who have these cancers and their family members. No treatment is given—the goal is to learn more about why…

This study is building a DNA registry for kidney cancer. Researchers will collect health information and genetic samples from 750 people, including patients, their family members, and healthy volunteers. The goal is to find better ways to prevent, diagnose, and treat kidney cance…

This study aims to help people with small kidney tumors (up to 4 cm) make informed decisions about their treatment. Researchers will develop a decision aid that explains the benefits and risks of each option based on the patient's own situation. The study will enroll 40 adults an…

This study looks at how urological diseases and treatments impact patients' jobs and daily lives. Researchers will survey 2,000 adults admitted to a hospital in Poland, focusing on those having major cancer surgeries or stone procedures. Participants will report their work status…

This study aims to see if watching a video before genetic testing helps people with certain cancers better understand their hereditary cancer risk. About 1020 adults with breast, ovarian, pancreatic, prostate, colorectal, renal, melanoma, or sarcoma cancers will take part. Resear…

This study tests a new radioactive tracer called 64Cu-GRIP B, which attaches to a protein (granzyme B) made by immune cells. By using PET scans, doctors hope to see which tumors are responding to immunotherapy. The trial involves about 91 adults with advanced prostate, kidney, or…

This study looks at 300 women aged 50 and older who have blood in their urine along with a bladder infection. Researchers want to see if these women need the full set of cancer tests (like a camera in the bladder and CT scans) or if they can safely skip them. The goal is to find …

This study collects blood, urine, saliva, and tissue samples from people who have or may have cancer, as well as their blood relatives. The goal is to help researchers learn more about the genetic and molecular causes of cancer. No direct treatment is given, but the samples may l…