RENAL CANCER

This study tests a new device that uses focused ultrasound (histotripsy) to break apart kidney tumors without any cuts or needles. About 67 adults with a single small kidney tumor (3 cm or less) will receive this non-invasive treatment. The goal is to see if the tumor is complete…

This study tested two immunotherapy drugs, nivolumab and ipilimumab, in 85 adults with advanced kidney cancer that could not be removed by surgery. The goal was to see if adding ipilimumab could turn stable or worsening disease into a better response. While not a cure, the approa…

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with advanced cancers that have stopped responding to standard treatments. The goal is to see if the drug is safe and can help control the cancer. About 350 people with various cancer types, …

This study tests whether adding a precise, high-dose radiation treatment (SBRT) can help restart the immune system's fight against cancer when immunotherapy drugs start to lose effect. About 69 adults with metastatic cancers (melanoma, lung, bladder, kidney, or head/neck) will re…

This study compares a new AI system, COSMO, against human pathologists to see which can more accurately diagnose brain, lung, and kidney cancers from tissue slides. About 30 pathologists will review up to 300 de-identified images, while the AI analyzes the same cases independentl…

This study tests whether advanced MRI scans can tell the difference between aggressive and harmless kidney tumors before surgery. Currently, standard scans show tumor size but not type, and biopsies are invasive. Researchers will compare MRI results with tissue removed during sur…

This study follows 750 adults with small kidney tumors who are not good candidates for surgery and instead receive freezing (cryotherapy) or heat (radiofrequency ablation) to destroy the tumor. Researchers will track survival, kidney function, complications, and hospital use, and…

This study uses special MRI scans to look at kidney tumors in 39 people scheduled for surgery. The goal is to see if these scans can correctly tell whether a tumor is cancerous and what type it is, as well as predict how well the kidney will work after part of it is removed. Part…