PSYCHOSIS

This study tests whether a personalized care plan—combining brain-training exercises, nutritional supplements, and online guidance—can improve daily functioning in young people at high risk for or in the early stages of psychosis. About 500 participants aged 15 to 30 will receive…

This study tests whether a type of talk therapy called Mentalization-Based Treatment (MBT) can help young people aged 14-30 who are at high risk for psychosis. Half of the 212 participants will get MBT plus standard care, and the other half will get standard care alone. The goal …

This study tests whether estradiol (a form of estrogen) can improve symptoms of depression, psychosis, and loss of pleasure in perimenopausal women aged 44-55. Participants will receive either estradiol or a placebo and undergo brain scans to see how the treatment affects reward-…

This study tests a brief virtual therapy called Action-Based Cognitive Remediation (ABCR) to help young people (ages 16-30) with early psychosis reduce their alcohol and cannabis use. The therapy involves 16 sessions over 2 months and aims to improve thinking skills that support …

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce symptoms like psychosis, depression, and mania in people recently diagnosed with bipolar I or schizoaffective disorder. Fifty adults aged 18-45 will follow the diet for 12 weeks alo…

This study tests whether breathing extra oxygen (normobaric oxygen therapy) can improve thinking, quality of life, and daily function in people who have had psychosis for less than 5 years. 20 participants aged 15-35 will be randomly assigned to receive oxygen or a placebo. The g…

This study tests whether a smartphone app called Kiso Mind is acceptable and practical for people with schizophrenia or schizoaffective disorder. About 60 participants will either use the app plus their usual care, or just usual care, for 12 weeks. The main goal is to see if peop…

This study tests whether a new combination drug, KarXT + KarX-EC, can safely reduce hallucinations and delusions in people with Alzheimer's disease. About 325 adults aged 55 to 90 with Alzheimer's and psychosis will receive either the drug or a placebo. The goal is to see if the …

This study tests a therapy called Targeted Cognitive Training (TCT) for 80 veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. TCT uses computer exercises to improve how the brain processes sounds and information. Researchers will use EEG brain s…

This study is testing a new blood test to see if it can help doctors tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will collect blood samples and mental health surveys from 500 adults over three visits. Th…

This study tests a 10-week, at-home computer program called SCORES that uses brain exercises and group support to help teens at high risk for psychosis think faster and connect better with others. Researchers want to see if improving processing speed can boost social functioning …

This study looks at how high- versus low-potency cannabis affects brain structure in young adults (ages 18-25) with early psychosis. Participants take metformin, a common diabetes drug, for 6 months to see if it helps brain health. The goal is to test if this approach is practica…

This study looks at how a brain chemical called glutamate relates to memory and attention in people who have recently experienced psychosis. Researchers will use brain scans and a gentle electrical stimulation technique to see if glutamate levels can predict who might benefit fro…

This study looks at whether adding five extra services—like peer support, digital outreach, and family therapy—to standard care helps people with early psychosis stay in treatment longer. About 350 participants from six clinics will either get standard care or the enhanced versio…

This study looks at why teens with autism or schizophrenia struggle with social interactions. Researchers will use brain scans to see how a 16-week social skills program changes brain activity and connections. The goal is to find out what brain differences are shared or unique be…

This small pilot study is testing a new program to help young adults (ages 18-35) recently diagnosed with bipolar disorder transition from hospital to community care. The program includes group education, one-on-one peer support, and help for community healthcare providers. The g…

This study aims to find biological markers in people with treatment-resistant schizophrenia who respond to the drug clozapine. Researchers will examine 200 participants using brain scans, blood tests, and spinal fluid analysis before and after 12 weeks of treatment. The goal is t…

This study looks at whether a non-invasive magnetic stimulation technique can improve how quickly people with psychotic disorders (like schizophrenia or bipolar disorder) solve challenging tasks. About 95 participants will do thinking exercises and get brain scans before and afte…

This study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, causes immune system problems. Researchers will measure changes in infection-fighting blood cells and antibodies in 24 patients over 6 months to a year. The goal is to understand the ris…

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illness like psychosis or schizophrenia. Researchers will use surveys, daily check-ins, and brain scans to understand these connections. The goal is to…

This study looks at how the immune system might play a role in psychotic symptoms and how well antipsychotic medications work. Researchers will collect blood and spinal fluid from 500 people with psychosis who are starting or changing medication, plus a healthy comparison group. …

This study explores whether precise brain stimulation can lower cannabis cravings in people with schizophrenia or schizoaffective disorder. Researchers will use a type of magnetic stimulation (rTMS) on specific brain areas and measure changes in cravings and brain activity. The g…

This study looks at language difficulties in people with psychosis, including those with schizophrenia or early warning signs. Researchers will give language tests to 90 patients and compare results with healthy controls. The goal is to understand how language problems connect wi…