PSYCHOSIS

This study tests a family-focused therapy program for 220 youth aged 13-25 who show early signs of psychosis risk. The therapy aims to reduce troubling symptoms and lower the chance of developing full psychosis over 18 months. Participants attend therapy sessions with a parent or…

This study looks at whether a combined aerobic and strength training program is feasible for adults with psychotic disorders. Forty participants will try the exercise program, and researchers will track how many complete it and how they feel about it. The goal is to see if this t…

This study tests a 15-session creative writing program called REWRITALIZE for people with severe mental illness, including schizophrenia and bipolar disorder. The program is led by a professional author and aims to improve personal recovery, thinking skills, and social connection…

This study tests a therapy called imagery rescripting in 8 people with early psychosis. The goal is to see if it helps change negative core beliefs and improve wellbeing and self-esteem. Participants receive 4-6 therapy sessions over a few weeks and are followed for 3 more weeks.…

This study tests whether Cognitive Behavioral Therapy for Insomnia (CBT-I) can improve sleep and daily functioning in 152 veterans who have both psychosis and insomnia. Participants receive CBT-I, a type of talk therapy that targets sleep problems, and researchers measure changes…

This study tests whether a 12-week mobile intervention can improve cognitive function and motivation in people with early psychosis. Researchers will follow 400 participants already receiving coordinated specialty care for 18 months, comparing those who use the mobile program to …

This pilot study is testing whether adults with acute psychiatric conditions like psychosis, anxiety, or depression can receive hospital-level care at home instead of in a hospital. The study will enroll about 41 people to see how many are eligible and willing to try this approac…

This study aimed to compare body temperature patterns between people with first-episode psychosis and those without. Researchers planned to measure temperature differences throughout the day and during rest versus activity. The study was withdrawn before enrolling any participant…

This study looks at brain images from 156 people experiencing their first episode of psychosis who have never taken medication. Researchers want to find out why some patients get better with standard treatment while others do not. By using different types of brain scans, they hop…

This study adapts a program called Youth-Nominated Support Team (YST) for suicidal adolescents who are at clinical high risk for psychosis. Researchers will test whether involving a support team chosen by the teen can improve social connectedness, hope, and treatment engagement. …

This study is collecting information from over 2,600 young people (ages 12-30) who are at clinical high risk for psychosis, along with healthy volunteers. Researchers will use clinical assessments, cognitive tests, and biomarkers to build computer algorithms that can predict whet…

This study looks at how the brain handles working memory in people with early psychosis. Researchers use a noninvasive technique called TMS (magnetic pulses on the scalp) along with brain scans to measure brain activity. The goal is to understand the brain circuits involved, not …