PSYCHOSIS

This study tests whether adding cannabidiol (CBD) to the standard medication clozapine can improve symptoms in people with treatment-resistant psychosis. About 250 participants will receive either CBD or a placebo for 12 weeks, alongside their usual clozapine. The goal is to see …

This study tests whether a supervised strength training program can prevent harmful weight gain and improve physical health in people recently diagnosed with psychosis who are starting antipsychotic medication. Forty participants will be randomly assigned to either standard care …

This study tests a therapy program called the Cannabis Clinic for Psychosis (CCP) to help people with first-episode psychosis reduce or stop cannabis use. About 80 adults under early psychosis care who want to cut down will either get the CCP therapy right away or wait and receiv…

This study tests whether a link worker—someone who helps connect people to services—can support adults with severe mental health issues (like psychosis) to attend routine dental checkups. About 480 participants will either get usual care or extra help from a link worker. The goal…

This study compares two types of brain stimulation (accelerated theta burst and high-frequency TMS) against a fake treatment to see if they can improve thinking and memory in people with schizophrenia that hasn't responded well to standard treatments. Ninety adults on clozapine w…

This study tests whether a 12-week online program can improve motivation and goal-setting in people with schizophrenia or early psychosis. Each week, participants complete a 20-30 minute session focused on boosting mood and positive feelings. The goal is to see if this approach h…

This study looks at whether a type of talk therapy called narrative exposure therapy (NET) is possible and helpful for people with psychosis who have experienced trauma. One participant will receive NET sessions and complete questionnaires about their symptoms. The goal is to see…

This small study will test whether a culturally-adapted form of cognitive-behavioural therapy (CBT) is practical, acceptable, and safe for Black Sub-Saharan African and Caribbean people who experience psychosis. Six participants will attend up to 16 therapy sessions and complete …

This study tests whether adding cannabidiol (CBD) to standard antipsychotic medication can improve symptoms in people experiencing their first episode of psychosis who haven't responded well to initial treatment. About 250 participants aged 16-40 will receive either CBD or a plac…

This study looks at how two medications, modafinil and d-serine, affect decision-making and brain activity in people who have had psychosis symptoms for less than five years. About 24 participants will take each drug or a placebo before playing computer brain games and having fMR…

This study looks at how understanding health information (health literacy) influences how people with schizophrenia feel about taking medication. Researchers will work with 34 patients in a hospital to test their knowledge and attitudes, and see if improving health literacy helps…

This study tests whether smartphone sensors can detect moments of low mood in people with early psychosis and deliver brief mental health exercises at the right time. Ten adults with psychosis and mild depression or anxiety will use a special app for 10 weeks. The goal is to see …

This study looks at how people with a first episode of psychosis tell their life stories and whether that relates to their well-being and recovery. Researchers will compare 96 participants—those with early psychosis, those with long-term psychosis, and healthy volunteers. The goa…