PREECLAMPSIA

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will be randomly assigned to use CPAP or not. The goal is to see if …

This study tests whether keeping blood pressure below 140/90 mmHg in pregnant women with preeclampsia or gestational hypertension can safely prolong pregnancy. Researchers will measure how many extra days women stay pregnant before delivery. The goal is to reduce risks for both m…

This early-stage study tests a single injection of CBP-4888 in 60 hospitalized pregnant women with preterm preeclampsia, a serious condition causing high blood pressure and organ stress. The goal is to find a safe dose that lowers harmful proteins in the blood, helping manage the…

This study tests a medication called ravulizumab in pregnant women with severe preeclampsia or HELLP syndrome, serious conditions that can harm both mother and baby. The goal is to see if the drug can improve health markers and extend pregnancy duration. About 14 participants wil…

This study tests whether a one-time IV treatment of stem cell exosomes can repair blood vessel damage in 80 women who recently had preeclampsia. Half receive the treatment, half a placebo. The goal is to improve blood vessel function and lower the risk of future heart disease. Fo…

This study tests whether taking atorvastatin for 3 months after breastfeeding can reduce long-term heart disease risk in women who had high blood pressure disorders during pregnancy. 76 participants will receive either the drug or a placebo. The goal is to see if this short treat…

This study looks at whether using a blood test (sFlt-1/PlGF) to guide delivery timing can reduce the number of labor inductions in women with mild preeclampsia at term (36-39 weeks). Researchers will compare this approach to standard care in 750 women. The goal is to avoid unnece…

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function in pregnant people with preeclampsia, a serious condition that can harm both mother and baby. Researchers will measure blood vessel health in the arm, skin, and placenta. The goal is to…

This study tests whether metformin, a drug used for diabetes, can safely prolong pregnancy in women diagnosed with preterm preeclampsia. Currently, the only way to stop the disease is to deliver the baby early, which can cause serious health problems for the newborn. The trial wi…

This study tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and health education. Researchers want to see if it lowers blood pressure and helps…

This study tests whether taking low-dose aspirin after a pregnancy complicated by preeclampsia can repair blood vessel damage and lower the risk of future heart disease. Researchers will measure how well blood vessels work in 40 women who had preeclampsia in the past 5 years. The…

This study tests whether adding a specially trained doula to standard care helps new mothers with pregnancy-related high blood pressure improve their blood pressure one year after giving birth. About 454 women who had preeclampsia or similar conditions will be randomly assigned t…

This study tests whether taking spironolactone for three months after delivery can improve blood pressure and heart health in women who had preeclampsia or gestational hypertension and were overweight before pregnancy. About 204 women will be randomly assigned to receive the drug…

This study looks at whether a lung ultrasound can help find extra fluid in the lungs of pregnant women with severe preeclampsia. About 202 women will get ultrasounds at three key times: when they enter the hospital, right after giving birth, and 7-10 days later. The goal is to ca…

This study is testing whether a quick, non-invasive test of blood vessel health can help predict preeclampsia and other high blood pressure disorders in pregnancy. Researchers will measure artery stiffness and tiny blood vessel function in 400 first-time pregnant women during the…

This study looks at whether three substances in the blood can help doctors diagnose and monitor preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will measure these markers in 120 pregnant women between 20 and 36 weeks. The goal is to find a b…

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…

This study looks at whether natural salicylates (similar to the active ingredient in aspirin) found in foods can help prevent preeclampsia, a serious pregnancy condition. Researchers will track the diets of 500 pregnant women and measure salicylate levels in their blood and urine…

This large study tests whether taking 162 mg of aspirin daily is better than the usual 81 mg dose at preventing high blood pressure disorders like preeclampsia during pregnancy. Over 10,000 pregnant individuals at higher risk will be followed to see which dose works best and what…

This study tests if providing healthy meals, nutrition support, and health coaching to pregnant women at high risk can prevent conditions like gestational diabetes and preeclampsia. 100 participants will either receive standard care or the full program. Researchers will compare o…

This study looks at whether a special type of physical therapy, which involves gentle pressure on certain body points, can help lower blood pressure in pregnant women with preeclampsia. Preeclampsia is a serious condition that causes high blood pressure and can harm both mother a…

This study looks at why low-dose aspirin doesn't always prevent preeclampsia, a serious pregnancy complication. Researchers will study genetic and lab factors in 130 women who had preeclampsia before and took aspirin in a later pregnancy. The goal is to understand why aspirin wor…

This study looks at pregnant people at risk for preeclampsia who are taking aspirin as part of their care. Researchers will collect blood samples up to four times during pregnancy to measure proteins from the placenta. The goal is to understand how aspirin affects these proteins …

This study looks at tiny particles called exosomes released from the placenta that may cause preeclampsia, a serious pregnancy condition. Researchers will collect blood and tissue samples from 64 women with preeclampsia and study these particles in the lab and in animals. The goa…

This study follows 100 women who had preeclampsia, HELLP syndrome, or kidney disease during pregnancy. Researchers measure blood vessel stiffness and collect blood samples to build a biobank. The goal is to better understand long-term heart and kidney health risks, not to test a …

This study looks at whether a blood gas test can help tell how severe preeclampsia is in pregnant women. Researchers will compare results from 100 women with severe preeclampsia and 100 healthy pregnant women. If the test works, it could give doctors a new way to predict complica…

This study aims to find early warning signs of preeclampsia, a serious pregnancy complication, by analyzing tissue from the area where the mother and baby meet. Researchers will collect small samples from over 2,000 pregnant women between weeks 9 and 15 of pregnancy. By comparing…

This study looks at how the body processes aspirin in pregnant women who are at risk for preeclampsia, a serious condition involving high blood pressure. Researchers will measure aspirin byproducts and markers of metabolic health in 50 participants. The goal is to better understa…

This study looks at why women who had preeclampsia during pregnancy are more likely to develop heart disease later in life. Researchers will test how a specific receptor in blood vessels affects function after a high-salt meal. The study involves 40 women (some with past preeclam…

This study looks at why pregnant women living at high altitude have higher rates of poor fetal growth and preeclampsia. Researchers will collect tissue samples from 84 women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude). By comparing blood…

This study is testing two new ultrasound techniques to see if they can better detect fetal growth restriction (FGR), a condition where a baby is smaller than expected. Researchers will compare these scans in 60 pregnant women, some with healthy pregnancies and some with FGR. The …

This study looks at 500 women who recently gave birth—250 with preeclampsia and 250 without—to see if exercise stress tests can spot early signs of heart failure with preserved ejection fraction (HFpEF). Researchers will track heart function and blood markers over a year. The goa…