PREECLAMPSIA

This study is testing whether taking low-dose aspirin after pregnancy can help repair blood vessel damage in women who had preeclampsia. Researchers want to see if this common medication can reduce the higher risk of future heart disease these women face. The study will measure b…

This study is testing whether a 3-month course of the medication spironolactone, started soon after delivery, can improve blood pressure and heart health in women who had high blood pressure during pregnancy. It focuses on women who also have overweight or obesity, as they are at…

This study is testing whether carefully lowering blood pressure in pregnant women with preeclampsia or gestational hypertension can help them stay pregnant longer. Researchers want to see if this approach allows babies more time to develop before birth, which could lead to better…

This study is testing if a common cholesterol-lowering drug (atorvastatin) can reduce the long-term risk of heart disease in people who developed high blood pressure during pregnancy. After they stop breastfeeding, 76 participants will take either the drug or a placebo pill for t…

This study is testing whether using a specific blood test can help doctors decide when to deliver babies for women with a mild form of preeclampsia. The goal is to safely delay delivery for some women, allowing their babies more time to develop, without increasing risks to the mo…

This study is testing a new therapy to see if it can help repair blood vessel damage in women who recently had preeclampsia, a serious pregnancy complication. The treatment uses tiny healing particles called exosomes, which come from stem cells. Researchers will give the treatmen…

This early-stage study is testing a new injection called CBP-4888 in pregnant women hospitalized with preterm preeclampsia, a serious blood pressure condition. The main goal is to find a safe and tolerable dose and to understand how the drug moves through the body. Participants w…

This study is testing if adding a specially trained 'heart health doula' to standard care helps new mothers recover from pregnancy-related high blood pressure. Researchers will compare two groups: one gets standard home blood pressure monitoring, and the other gets that plus week…

This study is testing whether the medication ravulizumab can help control severe preeclampsia and HELLP syndrome, dangerous blood pressure disorders that can occur during pregnancy. The trial will involve 14 pregnant individuals who develop these conditions before 34 weeks of pre…

This study is testing whether a simple, non-invasive lung ultrasound can reliably detect dangerous fluid buildup in pregnant women with severe preeclampsia. Researchers will scan the lungs of 202 women at three key times—upon hospital admission, right after delivery, and about a …

This study is testing two new types of ultrasound imaging to see if they can better check the health of the placenta during pregnancy. Researchers will compare scans from 60 pregnant people—some with a condition where the baby is growing too slowly and some without—to see if the …

This study is testing whether three specific substances measured in a pregnant woman's blood can help doctors better diagnose and monitor preeclampsia. Preeclampsia is a serious condition involving high blood pressure that can harm both mother and baby. Researchers will enroll 12…

This study aims to find better ways to predict which pregnant women will develop serious high blood pressure conditions like preeclampsia. Researchers will test 400 women in their first trimester using special blood vessel measurements and blood tests. The goal is to see if these…

This study aims to see if adding a blood-thinning medication (low molecular weight heparin) to standard low-dose aspirin is more effective at preventing preeclampsia than aspirin alone in pregnant women identified as high-risk. It will involve 100 women who will start treatment b…

This study monitors women who had preeclampsia, HELLP syndrome, or kidney problems during pregnancy to understand their long-term heart and kidney health risks. Researchers will measure blood vessel stiffness and collect health data without changing participants' standard medical…

This large study aims to find out if a higher daily dose of aspirin (162 mg) works better than the standard lower dose (81 mg) at preventing serious high blood pressure conditions during pregnancy. It will enroll over 10,000 pregnant individuals who are at risk for these complica…

This study is testing whether providing free healthy meals and weekly health coaching to pregnant women can prevent serious complications like gestational diabetes and preeclampsia. Researchers will compare 100 at-risk pregnant women who receive the meal program and coaching to t…

This study is testing whether treating sleep apnea with a CPAP machine during pregnancy can reduce serious high blood pressure conditions like preeclampsia. Researchers will enroll 1,500 pregnant women with mild to moderate sleep apnea and randomly assign them to use either CPAP …

This study aims to understand if a simple blood test can help predict how severe preeclampsia might become. Researchers will compare blood gas measurements from 100 pregnant women—half with severe preeclampsia and half with normal blood pressure. The goal is to find better marker…

This study aims to understand why women who had preeclampsia during pregnancy have a higher lifelong risk of heart disease. Researchers will examine how small blood vessels in the skin react to a high-salt diet and a test medication. The goal is to learn about the underlying mech…

This study aims to understand why low-dose aspirin, a common preventive treatment, sometimes fails to stop preeclampsia from recurring in high-risk pregnancies. Researchers will enroll 130 women with a history of preeclampsia who took aspirin in a later pregnancy. They will compa…

This study aims to understand how pregnant people at risk for preeclampsia process aspirin and how that relates to their metabolic health. Researchers will enroll 50 participants who are already recommended to take aspirin for prevention. The study involves blood tests, urine col…

This study aims to understand why pregnant women living at high altitudes have higher rates of fetal growth restriction and preeclampsia. Researchers will compare tissue samples from women giving birth in Denver versus Summit County, Colorado, to see if altitude affects blood ves…

This study aims to understand how preeclampsia, a serious pregnancy complication, might lead to future heart problems. Researchers will collect blood and tissue samples from 64 pregnant women, some with preeclampsia and some without, to study tiny particles called exosomes. By an…

This study aims to find new markers in the blood that can show how the placenta is working and how it responds to low-dose aspirin in pregnant people at risk for preeclampsia. Researchers will collect blood samples from up to 1,000 participants during pregnancy to analyze tiny pa…

This study aims to understand what causes preeclampsia, a serious pregnancy complication, by looking for early molecular changes in pregnancy tissue. Researchers will analyze small tissue samples from over 2,000 pregnant women between 9 and 15 weeks of pregnancy. The goal is to f…