PARKINSON DISEASE (DISORDER)

This study tests two different home exercise programs to see which one better helps people with Parkinson's disease avoid falls. Thirty participants will do exercises at home for six weeks, and researchers will check their balance, walking, and fear of falling. The goal is to fin…

This study tests a treatment called Lecigon, a gel given through a tube into the intestine, for people with Parkinson's disease who have mood or behavior problems from their current medications. The goal is to see if Lecigon reduces these side effects better than standard care. A…

This study tests a supplement made from a compound found in broccoli (glucoraphanin) in 300 people with Parkinson's disease, relapsing-remitting multiple sclerosis, or certain childhood nerve and muscle diseases. The goal is to see if it can protect the brain and slow disease pro…

This study looks at whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease. Researchers want to see if a protein called alpha-synuclein is present in the colon of people with Parkinson's. The goal is to catch the disease earlier, before mo…

This study tests whether a gentle, non-invasive nerve stimulation called taVNS can improve how the body controls heart rate and blood pressure in people with Parkinson's disease. 24 participants will receive taVNS while performing simple physical tasks. The goal is to see if this…

This study tests a non-invasive brain stimulation device (Sphere V3.0) to improve movement problems like tremor and stiffness in people with Parkinson's disease. Thirty adults aged 18-80 will use the device at home for 13 minutes each weekday over 3 weeks, with all assessments do…

This study tests an experimental drug called IRL757 in 75 people with Parkinson's disease who also have apathy (loss of interest or motivation). The main goal is to check if the drug is safe and tolerable over 12 weeks. Researchers will also see if it helps improve apathy symptom…

This study tests whether daily 30-minute sessions of transcranial pulsed electromagnetic field (T-PEMF) stimulation can improve movement and reduce medication needs in people with Parkinson's disease. 90 participants will receive either real or sham treatment for 6 months, then a…

This study aims to help people with Parkinson's disease exercise safely at home and track their sleep using a special headband. Researchers will test if a high-intensity workout program, originally done in a lab, works well when done remotely. Sixteen participants in Colorado wil…

This study tests whether motor imagery training—practicing movements in your mind—can reduce fear of movement (kinesiophobia) and improve walking and balance in people with Parkinson's disease. Researchers will enroll 50 adults aged 40-75 with mild to moderate Parkinson's. Partic…

This study tests whether shining special light on the whole body (photobiomodulation) can help with movement and thinking problems in people with Parkinson's disease. Fifteen adults with mild to moderate Parkinson's will receive about 30 sessions over 10 weeks. Researchers will m…

This study looks at whether a 12-week supervised aerobic exercise program can improve brain blood flow, thinking skills, and walking in people with Parkinson's disease. About 40 participants with mild to moderate Parkinson's will either do the exercise program or continue their u…

This study looks at whether using walking poles during an 8-week walking program can improve walking, movement, and thinking in people with Parkinson's disease. About 40 participants will either walk with poles or without, and their progress will be measured before, after, and 3 …

This study tests whether mental imagery — picturing movements without actually doing them — can immediately improve hand and finger skills in people with Parkinson's disease. About 30 adults with mild to moderate Parkinson's will participate. Researchers will measure how quickly …

This study tests whether a daily probiotic supplement can reduce depression in people with Parkinson's disease. Sixty adults aged 40–80 with mild to moderate Parkinson's and depression will take either a multi-strain probiotic or a placebo for 12 weeks. Researchers will measure c…

This study tests a 6-week group program that teaches people with Parkinson's disease how to manage fatigue and conserve energy. Researchers will compare the program to simply giving out information sheets. The goal is to see if the group approach helps participants feel more conf…

This study tests a home-based fall prevention program for people with Parkinson's disease. About 50 participants will have their homes assessed by occupational therapists to find fall risks and get recommendations for safety changes. The goal is to help people feel safer and more…

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation (TIS) can improve motor symptoms like stiffness, slowness, and walking difficulty in people with Parkinson's disease. Sixty-eight adults with mild-to-moderate Parkinson's …

This study tests a device called EarStim that uses mild electrical pulses on the ear to temporarily improve movement in people with Parkinson's disease. About 90 adults with moderate to severe Parkinson's who experience 'wearing-off' episodes will participate. The trial compares …

This early-stage study tests a single dose of SER-252 in 40 people with Parkinson's disease who experience motor fluctuations (uncontrolled movements). The main goal is to check the drug's safety and how the body processes it. Participants receive either SER-252 or a placebo, and…

This study is testing if a new type of physical therapy using robotic arms and video game-like exercises can help improve both thinking skills and arm movement in adults with Parkinson's disease, multiple sclerosis, or who have had a stroke. Researchers want to see if this high-t…

This study looks at brain activity in 30 people with Parkinson's disease who have a brain pacemaker (deep brain stimulation). Researchers want to understand why symptoms like movement problems and mood changes can come and go. By recording brain signals during medication changes,…

This study is looking for new ways to detect Parkinson's disease, Alzheimer's disease, and type 2 diabetes earlier and track them better. Researchers will study blood samples and brain scans from 500 participants to find unique markers. The goal is to improve diagnosis and monito…

This study looks at whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). Researchers are checking for a protein called alpha-synuclein in colon tissue from 40 adults aged 40-99 who already have Parki…

This study aims to find proteins and genetic material in the blood that can predict how well a person with Parkinson's disease will respond to deep brain stimulation (DBS) surgery. Researchers will collect blood and leftover brain tissue from 30 participants undergoing DBS, and t…

This study follows 450 people with Parkinson's disease for four years to learn why some become less active and what helps them stay active. Participants wear activity monitors and complete tests and questionnaires. The goal is to identify early warning signs and develop better su…

This study translates a questionnaire about stomach and bowel problems (GIDS-PD) into Italian for people with Parkinson's disease. Researchers will check if the Italian version works well by testing it with 190 patients across multiple centers. The goal is to help doctors better …

This study looks at whether stimulating a specific brain area (the posterior parietal cortex) can help people with Parkinson's disease transfer walking skills learned on a treadmill to walking on the ground. 24 participants will receive either real or fake brain stimulation to co…

This study looks at why people with Parkinson's disease have trouble activating their leg muscles. Researchers will test if stimulating a nerve in the neck (vagus nerve) can improve muscle activation, walking, and balance. The study involves 75 participants and aims to better und…