PARKINSON DISEASE (DISORDER)

This study tests a new method to deliver AB-1005 into the brain for people with advanced Parkinson's disease. The goal is to make the procedure faster and easier while still getting the drug to the right area. About 12 participants aged 45 to 75 will be enrolled. The study focuse…

This study tests a home-based training program for people with Parkinson's disease who also have mild cognitive impairment and are at high risk for dementia. Participants will cycle on a stationary bike while doing brain games on a tablet, three times a week for 30 minutes. The g…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve how people with Parkinson's disease start walking and move around. Researchers will compare high-frequency and low-frequency stimulation to a sham (fake) treatment in 81 participants. The …

This study tests whether adding whole-body vibration (standing on a vibrating platform) to a home exercise program helps people with Parkinson's disease improve their balance, mobility, and sense of body position better than exercise alone. 68 participants aged 50-75 will be rand…

This study tests whether an accelerated course of repetitive transcranial magnetic stimulation (rTMS) can improve movement and thinking in people with mild to moderate Parkinson's disease. Forty participants aged 50 to 90 will receive six sessions of non-invasive magnetic pulses …

This study tests a new approach to help people with early Parkinson's disease who have mild memory or thinking problems. Instead of doing brain games, participants will work with a therapist to develop practical strategies for everyday challenges, like remembering appointments or…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can improve walking and balance in people with Parkinson's disease. About 30 adults with Parkinson's will receive either the real stimulation or a sham (fake) version alongside physical …

This study tests a 6-week exercise program called SwallowFit for people with Parkinson's disease who have trouble swallowing. About 80 adults will either do the exercises or receive standard care. The goal is to see if the program improves swallowing fitness and quality of life.

This study tests whether repeated sessions of a gentle, non-invasive brain stimulation technique called tDCS can improve movement in people with Parkinson's disease. Researchers will give 30 participants multiple tDCS sessions over a week and measure changes in motor function. Th…

This study tests a new, non-invasive brain stimulation method called temporal interference stimulation (TIS) for people with mild to moderate Parkinson's disease. The goal is to see if TIS can improve movement and other symptoms without the need for surgery. Researchers will use …

This study tests a smartphone app called CuePD that uses a person's favorite music to help retrain walking in people with Parkinson's disease. Over 12 weeks, 40 participants will use the app at home and while out walking to see if it improves gait and reduces fall risk. The goal …

This study tests a non-invasive brain stimulation technique called tDCS in 20 people with Parkinson's disease who have trouble with verbal fluency (finding words). The goal is to see if it can improve thinking, memory, and movement. Participants will receive either real or fake s…

This observational study aims to understand why some people with Parkinson's disease experience visual hallucinations. Researchers will compare how prior expectations influence false perceptions during a computer task in patients with and without hallucinations, as well as health…

This study looks at how the nerves connecting the gut and brain might be involved in Parkinson's disease. Researchers will compare people with Parkinson's, those at risk, and healthy volunteers. Participants give blood, stool, and saliva samples, plus undergo X-rays and a scope e…

This study aims to find biological markers in blood, urine, and stool that can help doctors distinguish Parkinson's disease from other similar brain disorders early on. Researchers will study 200 adults aged 40-80 with early symptoms, plus healthy volunteers, over 12-18 months. W…

This study tests two artificial intelligence (AI) models that aim to predict how Parkinson's disease will progress and whether medication side effects will occur. Researchers will collect data from 100 people with Parkinson's using a smartwatch and a mobile app, along with their …