Ear zaps could help Parkinson's patients walk better
NCT ID NCT07366411
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a mild electrical stimulation applied to the ear (taVNS) can improve walking, balance, and movement in people with Parkinson's disease when combined with physical therapy. Thirty participants will receive either real or sham stimulation during therapy sessions. The goal is to see if this non-invasive approach can enhance functional mobility beyond therapy alone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcutaneous auricular vagus nerve stimulation (taVNS) device
- What this could lead to
- If it works, this could offer a safe, non-drug way to boost the benefits of physical therapy for walking and balance in Parkinson's disease.
- What could go wrong
- This is a small early-phase trial with only 30 participants, so results may not apply to everyone. The stimulation is mild and may not produce meaningful improvements over sham treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * clinical diagnosis of PD provided by a neurologist; * undergoing regular antiparkinsonian drug treatment (at least three months of regular and stable use); * aged 40 years or older; * with a Hoehn \& Yahr stage of 2.5 to 4. Exclusion Criteria: * other neurological disorders, postural hypotension, vestibular, musculoskeletal, or visual disorders that compromise performance in the proposed tests; * other osteomyoarticular diseases in the lower limbs that interfere with performance and locomotion; * Montreal Cognitive Assessment (MoCA) score lower than 21 points; * previous surgical procedure for PD.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Universidade Federal de Pernambuco
Recife, Pernambuco, 50670-901, Brazil
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