PANCREATIC DUCTAL ADENOCARCINOMA (PDAC)

This early-phase study tests an experimental drug called STRO-004 in adults with advanced solid tumors that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in more patients, and combining STRO-004 with…

This study tests a new treatment that delivers radiation directly to cancer cells. It is for people with advanced solid tumors that cannot be removed by surgery. The study will first find the safest dose and then check if the treatment shrinks tumors. About 270 adults with severa…

This study tests a new drug called BNT327 combined with chemotherapy in people with metastatic pancreatic cancer that has not been treated before. The goal is to see if the combination can shrink tumors and control the disease. About 105 adults will take part, and the study is cu…

This early-phase trial tests whether adding chemotherapy directly into the abdomen (intraperitoneal paclitaxel) to standard IV chemotherapy (NALIRIFOX) is safe and effective for adults with pancreatic cancer that has spread to the lining of the belly. Ten participants will receiv…

This early-stage study tests an experimental drug called RMC-5127 in adults with advanced solid tumors that have a specific KRAS G12V mutation. The main goals are to check the drug's safety, how the body processes it, and whether it can shrink tumors. About 574 participants will …

This phase 3 trial tests a new drug called daraxonrasib, alone or with standard chemotherapy, for people with metastatic pancreatic cancer that has spread. About 900 adults with a specific RAS gene mutation will be randomly assigned to one of three treatment groups. The study aim…

This study tests a new drug called RMC-6236 in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have specific RAS gene mutations. The main goals are to check the drug's safety and find the right dose. About 754 people will take part, and the drug is…

This study is testing a new test called NEO-Match® that uses nanomechanical profiling to analyze biopsy samples from people with suspected pancreatic cancer. The goal is to see if the test can predict how well patients will respond to treatment and help doctors make better decisi…

This study is developing a blood test that looks for tiny molecules called miRNAs to detect several types of digestive system cancers (like liver, pancreatic, and colon cancer) early. The goal is to create a simple, noninvasive screening tool that could replace or supplement inva…

This study tests a medical food powder (Encala) to see if it helps people with pancreatic cancer absorb fat better and reduce stomach problems like diarrhea and weight loss. About 18 adults with pancreatic cancer who have trouble digesting fat will take the powder for 4 weeks. Th…

This study looks at how the genetic profile of pancreatic cancer affects how well it responds to a chemotherapy combination called FOLFIRINOX, given before surgery. About 45 adults with non-metastatic pancreatic cancer will participate. Researchers will take biopsies and blood sa…