PANCREATIC ADENOCARCINOMA

This study is for people whose advanced pancreatic cancer has spread and has a specific genetic change (BRCA1, BRCA2, or PALB2 mutation). It compares a new three-drug chemotherapy combination (NABPLAGEM) against the current standard two-drug combination. The goal is to see if add…

This early-stage study is testing a new experimental drug called SGN-MesoC2 in people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to find the safest dose and understand how the drug behaves in the body. The study includes 19 pa…

This early-stage study is testing a combination of standard chemotherapy drugs, a diabetes medication (metformin), and a specific blend of dietary supplements in patients with advanced pancreatic cancer that cannot be removed by surgery. The main goal is to see if this four-part …

This study is testing whether a specific surgical technique called 'peri-adventitial dissection' improves outcomes for pancreatic cancer patients. During pancreas removal surgery, surgeons will either use this technique or standard methods to see which approach better removes all…

This study is testing a new way to treat advanced pancreatic cancer by placing tiny radioactive seeds directly into the tumor. The seeds release a powerful form of radiation called alpha radiation, which is designed to destroy cancer cells from the inside. Researchers are checkin…

This study is testing a new oral medication called IMM-1-104 for people with advanced solid tumors that have spread. The main goals are to find a safe dose and see if the drug can shrink tumors in cancers like pancreatic, lung, and melanoma. Participants will take the drug alone …

This study is testing a flexible treatment plan for people with pancreatic cancer that might be removable by surgery. Doctors will give one chemotherapy combination first, then switch to a different one if the cancer isn't responding well or if side effects are too severe. The go…

This study is testing whether combining a drug called durvalumab (an immunotherapy) with a precise, high-dose form of radiation is safe and effective for people with locally advanced pancreatic cancer. The goal is to better control the cancer, potentially shrink tumors to make su…

This study is testing whether combining two existing cancer drugs can help control advanced cancers that usually don't respond to standard immunotherapy. The trial is for adults with specific advanced cancers, like certain types of pancreatic, breast, and prostate cancer, who hav…

This early-stage study is testing the safety and best dose of a new drug called sEphB4-HSA when given alongside standard chemotherapy. It involves about 61 people with specific advanced or spreading cancers, including pancreatic, lung, and head/neck cancers, that have stopped res…

This study is testing two different drug combinations to see how they affect advanced cancers that have stopped responding to standard treatments. It will enroll about 90 people with specific types of advanced colorectal cancer, pancreatic cancer, or a soft tissue sarcoma. The ma…

This early-stage trial is testing the safety and finding the right dose of a two-drug combination (naptumomab estafenatox and durvalumab) for people with advanced or metastatic solid tumors. It will enroll about 120 adults with one of many eligible cancer types, including breast,…

This study is testing if adding two experimental drugs to standard chemotherapy can prevent advanced pancreatic cancer from becoming resistant to treatment. The goal is to help the standard drugs work better and for longer. The study will involve about 70 adults with newly diagno…

This early-stage study is testing a new immunotherapy drug called DECOY20, both alone and combined with another cancer drug (tislelizumab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find safe doses, check for s…

This early-stage study is testing the safety and best dose of a new targeted drug, anetumab ravtansine, when combined with other cancer treatments. It is for people with advanced pancreatic cancer that has a specific marker called mesothelin. The goal is to see if these combinati…

This study is testing whether a combination of three chemotherapy drugs is safe and effective when given before surgery for pancreatic cancer. The goal is to shrink tumors to make them easier to remove completely. The trial involves 45 adults with newly diagnosed pancreatic cance…

This study is testing a computer model designed to spot people at high risk for pancreatic cancer by analyzing their electronic health records. It will follow over 6 million adults from 44 U.S. healthcare centers for up to three years to see if the model's predictions are accurat…

This study is testing whether adding a digestive enzyme supplement called Pancreaze to standard cancer care helps pancreatic cancer patients maintain their weight and improve their quality of life. The research focuses on patients who have lost significant weight and have trouble…

This study is testing whether a safe, home-based strength training program delivered via video calls can help people with pancreatic cancer. It aims to see if this approach helps patients maintain muscle, strength, and quality of life while they are receiving chemotherapy or reco…