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New drug combo shows promise in Hard-to-Treat cancers

NCT ID NCT02495896

First seen Nov 10, 2025 · Last updated Jun 02, 2026 · Updated 34 times

Summary

This early-phase study tests a new drug (sEphB4-HSA) combined with standard chemotherapy in people with advanced or metastatic solid tumors, including head and neck, pancreatic, lung, and gallbladder cancers. The goal is to find the best dose and check for side effects. About 61 adults with tumors that have spread will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Hoag Memorial Hospital Presbyterian

    Newport Beach, California, 92663, United States

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

Conditions

The condition(s) this trial relates to.

gallbladder neoplasm malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic adenocarcinoma pancreatic neoplasm Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.