Can a diabetes drug and special diet boost chemo for pancreatic cancer?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients must have a histologic diagnosis of pancreatic adenocarcinoma * Patient must have unresectable disease * Patients must not have received prior chemotherapy except for the following circumstances; gemcitabine and capecitabine chemotherapy given in the adjuvant setting is allowed if the recurrence is greater than 6 months from the completion of chemotherapy; radiation sensitizing doses of 5-fluororuracil or capecitabine are allowed as part of adjuvant treatment and recurrence must be documented greater than 6 months from the completion of adjuvant therapy * Computed tomography (CT) or magnetic resonance imaging (MRI) scan must be obtained within 4 weeks prior to study entry * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 * Absolute neutrophil count \> 1,500/mcl * Platelet count \> 100,000/mcl * Creatinine \< 1.4 mg/dl and/or a measured creatinine clearance \> 60 cc/min * Bilirubin \< 1.4 mg/dl * Alanine aminotransferase (ALT), aspartate aminotransferase (AST) no greater than 3.0 times the upper limit of normal * Patients currently being treated for severe infections or who are recovering from major surgery or other intercurrent illnesses are ineligible until recovery is deemed complete by the investigator * Patients must not be pregnant or nursing; women and men of reproductive potential must have agreed to use an effective contraceptive method * All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines * Patients must be able to swallow pills and must not have malabsorption problems or ongoing nausea and vomiting that would affect oral treatment * No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years * Patients currently taking metformin will be eligible * Patients allergic to eggs are not eligible * Patients taking additional dietary/herbal supplements (excluding Senekot) outside of this protocol and refusing to stop are not eligible * Patients requiring warfarin are not eligible