OBESITY AND OVERWEIGHT

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help adults with obesity and binge-eating disorder reduce binge episodes and lose weight. About 105 participants will receive either tirzepatide, a placebo, or another drug (lisdexamfetamine), plu…

This study tests if tirzepatide, a weekly injection, can help 12 overweight or obese adults with well-controlled HIV lose weight and reduce chronic inflammation. Participants will receive increasing doses over 12 weeks, and researchers will track body weight, body composition, li…

This study tests whether a daily postbiotic supplement (resM™) can help overweight adults lose weight and improve metabolic health. Researchers will measure changes in weight, BMI, food cravings, and blood markers like glucose and insulin. 80 participants will be randomly assigne…

This study tests a new once-weekly injection called MET097 for weight loss in adults with obesity or overweight who also have related health issues like high blood pressure. About 3,500 participants will receive the shot or a placebo for up to 84 weeks. The goal is to see how muc…

This study tests whether a weekly injection of tirzepatide, a drug used for diabetes and weight loss, can reduce heavy drinking in adults who have alcohol use disorder and are overweight or obese. About 42 participants will receive either tirzepatide or a placebo for 8 weeks. Res…

This study tests whether a program combining a reduced-calorie Mediterranean diet, exercise, and lifestyle coaching can help middle-aged adults (30-50 years old) with metabolic syndrome lose 5-10% of their body weight and keep it off for a year. Researchers will compare this appr…

This study looks at what happens to muscle and fat when people take anti-obesity medications like semaglutide or tirzepatide, and whether adding aerobic or resistance exercise makes a difference. About 40 adults will be assigned to standard care, aerobic training, or resistance t…

This study compares three different programs to help pregnant women maintain a healthy weight. About 795 women at risk for obesity or diabetes will receive nutrition and exercise counseling, plus help overcoming barriers like food access. The goal is to see which approach works b…

This study looks at whether eating fresh watermelon every day for 6 weeks can improve gut health, including helpful bacteria, and heart health in young adults ages 18-30 who are overweight or obese. Participants will either eat watermelon or a low-fat snack. Researchers will meas…

This study looks at whether adding stair climbing to daily routines can lower blood pressure more than brisk walking alone. About 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk wa…

This study tests a new injectable drug, efsubaglutide alfa, to see if it helps people with overweight or obesity lose weight safely. About 200 adults aged 18 to 75 will receive either the drug or a placebo for 22 weeks. The main goal is to measure how much weight they lose compar…

This early-stage study tests a new drug, WVE-007, in 136 adults aged 18 to 60 who are overweight or have obesity (BMI 28-35). The main goal is to check the drug's safety and how the body processes it. Participants will receive either the drug or a placebo as a single injection, a…

This study tests whether a diet tailored to a person's unique metabolism can prevent type 2 diabetes better than standard dietary advice. Researchers will group 240 overweight or prediabetic adults by their metabolic type and give each group a personalized diet plan. The goal is …

This study tests a weight loss program for college students who are overweight or have obesity. The program focuses on making small, manageable changes to eating and activity. Researchers want to see if students find the program acceptable and if it leads to meaningful weight los…

This study tests a 6-month mobile program that combines physical activity, healthy eating, and group support to help older adults with knee or hip arthritis reduce pain and improve daily function. Two hundred participants aged 65+ will be randomly assigned to the program or usual…

This study looks at whether adding yoga to a standard weight loss program helps adults with overweight or obesity lose more weight than just doing aerobic exercise alone. About 290 participants will follow a 12-month program with diet changes and either aerobic exercise plus yoga…

This study tests whether adding sleep coaching to standard weight-loss treatment helps teens with overweight or obesity lose more weight. About 126 teens aged 13-17 with poor sleep will be split into two groups: one gets standard care, the other gets standard care plus sleep advi…

This study is testing a smartphone app designed to help teenagers with obesity lose weight. The app is based on the idea that replacing unhealthy coping behaviors with healthy ones can stop overeating. Researchers will enroll 38 teens aged 14-21 to see if the app is easy to use a…

This study tests whether time-restricted eating (eating only during an 8-hour window each day) can help menopausal women—including those treated for hormone-sensitive breast cancer—lose weight, reduce menopause symptoms, and improve overall health. 84 women will be randomly assig…

This study looks at whether eating one cup of broccoli microgreens every day for two weeks is practical for obese breast cancer survivors. Researchers want to see if it improves metabolism and reduces inflammation, which may lower the risk of cancer returning. Twenty-four women w…

This study looks at why some children become overweight or obese by examining their eating behaviors, brain activity, and genetic factors. Researchers will study 210 children aged 7-12 from a larger family study. The goal is to find early clues that could lead to better ways to p…

This study looks at 200 adults who need a second weight-loss surgery (revision bariatric surgery) to see if using a robot or standard laparoscopic tools leads to fewer complications. The main goal is to compare rates of problems like leaks, bleeding, and infections between the tw…

This study follows 100 adults starting anti-obesity medications like semaglutide or tirzepatide to see how their body composition, muscle strength, and nutrition change over time. Participants will get periodic scans and strength tests, and complete online surveys about diet and …

This study looks at whether eating peanuts every day can improve bone health, metabolic health, and weight loss in overweight adults aged 50-75. Participants will be randomly assigned to eat either a daily peanut snack or a nut-free snack for 24 weeks while following a weight los…

This study follows over 4,000 adults from Shanghai communities to track how heart, kidney, and metabolic diseases develop and change over time. Participants were first checked between 2016-2017 and will be re-assessed through 2035. The goal is to understand risk factors and impro…

This study looks at two different training programs for doctors and health workers in community health centers that serve people on Medicaid. The goal is to see which training helps patients lose more weight and get better access to obesity care. About 6,200 patients and their pr…

This study looks at how ultra processed foods (like packaged snacks and sugary drinks) affect the way your body absorbs calories. Researchers will compare a diet where 80% of calories come from ultra processed foods to one where only 20% do. Twenty adults with a BMI between 30 an…

This study looks at how the gut's fermentation process affects insulin resistance in teenagers and young adults with obesity. Researchers will give a sugar drink (lactulose) to see how it changes fat breakdown and sugar production in the body. The goal is to better understand the…

This study examines 100 children aged 3-15 who had a minor injury, comparing those with a fracture to those without. Researchers measure vitamin D levels, bone markers, and body weight to see if these factors increase fracture risk. The goal is to better understand why some child…