16-Hour fasting may ease menopause symptoms and weight gain
NCT ID NCT06855784
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests if eating only during an 8-hour window each day (16-hour fast) helps menopausal women lose weight and reduce menopause symptoms. It includes women going through natural menopause or those with hormone-sensitive breast cancer. 84 participants will be randomly assigned to the fasting plan or their usual eating pattern for 12 weeks, with an optional 12-month follow-up.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 84 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2025
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 to 60 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women with confirmed physiological menopause without current anti-cancer treatment (group A), or women with menopausal symptoms in the context of aromatase inhibitors used as adjuvant therapy for hormone-sensitive non-metastatic breast cancers regardless of physiological menopause before the cancer diagnosis (group B) * Age 40-65 years * Body mass index 25-40 kg/m2 * Stable weight (± 2 kg) over the previous month * Eating window ≥ 12 hours (self-reported and measured during the run-in phase) * Able to give informed consent and follow the study procedures for the entire duration * Confident use of a smartphone and able to take regular pictures of food/drinks Exclusion Criteria: * On a hypocaloric restrictive diet, intermittent fasting or in a weight management program over the previous month * Previous bariatric surgery or planned during the study * Active eating disorder(s) or major mental illness at inclusion * Psychoactive treatment with recent or planned changes of drug compound or dosage * Treatments affecting body weight (e.g. glucocorticoids, GLP-1 receptor analogues) * Diabetes with hypoglycemic drug(s) will be excluded, however those with prediabetes (as defined by the American Diabetes Association) or diabetes with no risk of hypoglycemia (i.e. treated with non-hypoglycemic drugs or without medication) will be included * Active metabolic bone diseases (e.g. Paget disease, osteomalacia), however women with osteoporosis will be included * Shift work comprising night shifts (working between 11pm and 6am) over the previous 2 weeks or planned during the study * Travel/trip to a different time zone (≥ 2-hour time difference) over the previous 2 weeks or planned during the study * Enrolled in another interventional clinical trial (medication, surgery, medical device) over the previous 2 weeks or planned during the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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Contacts and locations
Locations
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Geneva University Hospitals
RECRUITINGGeneva, Canton of Geneva, 1211, Switzerland
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Other studies related to the condition(s) this trial covers.
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