OBESITY AND OVERWEIGHT
Clinical trials for OBESITY AND OVERWEIGHT explained in plain language.
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Plant extracts show promise for appetite control in obesity
Disease control OngoingThis study tests whether extracts from two plants, Cissus quadrangularis and Dichrostachys glomerata, can help manage weight in healthy overweight and obese adults. The goal is to see if these extracts increase a natural appetite-regulating hormone (GLP-1) and block an enzyme tha…
Matched conditions: OBESITY AND OVERWEIGHT
Phase: PHASE1, PHASE2 • Sponsor: University of Yaounde 1 • Aim: Disease control
Last updated May 26, 2026 05:57 UTC
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Berry and olive extract supplements put to the test for weight loss
Disease control OngoingThis study looks at whether eating more plant-based foods rich in polyphenols (like berries, nuts, and olive oil) or taking polyphenol supplements can help overweight adults lose weight and improve heart health. About 99 adults aged 25-45 with a BMI of 25-35 will follow a reduced…
Matched conditions: OBESITY AND OVERWEIGHT
Phase: NA • Sponsor: Universidad Catolica de Temuco • Aim: Disease control
Last updated May 26, 2026 05:48 UTC
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Personalized diet and exercise plans tested to prevent diabetes in people with disabilities
Disease control OngoingThis study aims to find the most effective weight loss strategy for adults with prediabetes and physical disabilities. Over 16 weeks, participants will try different diet plans, and those who don't lose enough weight will get extra exercise or time-restricted eating. The goal is …
Matched conditions: OBESITY AND OVERWEIGHT
Phase: NA • Sponsor: University of Alabama at Birmingham • Aim: Disease control
Last updated May 26, 2026 05:44 UTC
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New weekly shot shows promise for obesity in early trials
Disease control OngoingThis study tests a new drug called MET233, given as a weekly injection, to see if it is safe and how it works in adults who are overweight or have obesity but are otherwise healthy. About 120 participants will receive either the drug or a placebo for up to 12 weeks. The main goal…
Matched conditions: OBESITY AND OVERWEIGHT
Phase: PHASE1, PHASE2 • Sponsor: Metsera, a wholly owned subsidiary of Pfizer • Aim: Disease control
Last updated May 22, 2026 13:51 UTC
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New injection shows promise for shedding pounds in major trial
Disease control OngoingThis study tests an injectable drug called efsubaglutide alfa in 1003 overweight or obese adults. Participants receive either the drug or a placebo to see how much weight they lose over 18 to 48 weeks. The goal is to find out if the drug is safe and effective for weight managemen…
Matched conditions: OBESITY AND OVERWEIGHT
Phase: PHASE2, PHASE3 • Sponsor: Shanghai Yinnuo Pharmaceutical Technology Co., Ltd. • Aim: Disease control
Last updated May 19, 2026 11:47 UTC
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New weight loss drug HCR-188 enters first human safety trial
Symptom relief TerminatedThis early-phase study tests a new drug called HCR-188 in 48 overweight or obese adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo as injections. The goal is to check for side effects and gather initial data, not to treat…
Matched conditions: OBESITY AND OVERWEIGHT
Phase: EARLY_PHASE1 • Sponsor: Helicore Biopharma, Inc. • Aim: Symptom relief
Last updated May 22, 2026 13:54 UTC
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Scientists peek inside brown fat to see how it reacts to dieting
Knowledge-focused OngoingThis study looks at how brown fat—a special type of body fat that burns energy—changes when young adults with obesity follow a calorie-restricted diet. About 30 participants will either maintain their weight or lose 8-10% over 12-16 weeks. Researchers will use advanced scans and …
Matched conditions: OBESITY AND OVERWEIGHT
Phase: NA • Sponsor: Universidad de Granada • Aim: Knowledge-focused
Last updated May 26, 2026 05:46 UTC
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Can a natural hormone curb food cravings in the brain?
Knowledge-focused OngoingThis study looks at whether a natural hormone called LEAP2 can lower brain activity in response to food pictures in people with obesity. Twenty-eight men with a BMI between 30 and 50 will receive either LEAP2 or a placebo on two separate days and undergo brain scans. The goal is …
Matched conditions: OBESITY AND OVERWEIGHT
Phase: NA • Sponsor: University Hospital, Gentofte, Copenhagen • Aim: Knowledge-focused
Last updated May 18, 2026 12:00 UTC