MYELOPROLIFERATIVE NEOPLASM

This study is testing a combination of drugs to see if it can better prepare patients with advanced blood cancers for a stem cell transplant from a donor. The goal is to control the aggressive cancer cells before the transplant, which may help the new donor cells take hold and fi…

This study is testing a combination of two drugs, azacitidine and quizartinib, for adults with specific types of bone marrow and blood cancers (MDS and MDS/MPN). The goal is to find the safest and most effective dose and to see how well the combination controls the disease in pat…

This study is testing whether the drug luspatercept can help adults with certain lower-risk blood disorders (MDS or MDS/MPN) who have anemia and require regular blood transfusions. Participants will receive luspatercept along with standard supportive care to see if it reduces the…

This early-stage study is testing a new combination treatment for adults newly diagnosed with high-risk forms of acute myeloid leukemia (AML) and related blood cancers. The trial combines a standard chemotherapy regimen (FLAG-Ida) with an experimental targeted drug called pivekim…

This study is testing whether a drug called dexrazoxane can protect the heart from damage caused by powerful chemotherapy used to treat aggressive blood cancers like acute myeloid leukemia. It will enroll 100 patients with these cancers who are receiving a specific combination of…

This study is testing a refined procedure for umbilical cord blood transplants in adults and children with high-risk blood cancers like leukemia and lymphoma. The goal is to see if this optimized approach improves survival and reduces complications compared to standard transplant…

This early-stage study is testing a new therapy that uses specially trained immune cells from a donor to try to prevent blood cancers from coming back after a stem cell transplant. The goal is to see if these 'memory-like' natural killer (NK) cells, given with a supporting drug, …

This early-stage study is testing whether adding metal-detoxifying drugs to standard chemotherapy can help control acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Researchers want to see if lowering metal levels in the blood and bone marrow improves treatment res…

This study is testing a new treatment for adults and teens whose blood cancers like leukemia have come back after a stem cell transplant. The treatment involves giving patients special immune cells, called CIML NK cells, from their original transplant donor, along with a drug cal…

This study is testing whether removing a specific type of immune cell (called naive T cells) from a donor's stem cells before transplant can prevent chronic graft-versus-host disease in children and young adults with blood cancers. Chronic graft-versus-host disease is a serious c…

This study is testing a new combination of targeted drugs for people with advanced blood cancers that have a specific genetic change called an IDH1 mutation. The main goals are to find the safest dose and see how well the drug combo works to control the cancer. The trial is for a…

This study is testing whether combining two drugs, CPX-351 (a chemotherapy) and ivosidenib (a targeted pill), can help control a specific type of acute myeloid leukemia or high-risk MDS that has an IDH1 gene mutation. It will involve about 30 adults who are eligible for intensive…

This study is for people with acute leukemia or myelodysplastic syndrome (MDS) who need a stem cell transplant from a donor. The main goal is to find the best way to reduce a serious complication called graft-versus-host disease (GVHD), where the donor's immune cells attack the p…

This study is testing whether a combination of two drugs, venetoclax and azacitidine, is safe and effective for people with advanced forms of a rare blood cancer called myeloproliferative neoplasm. The trial will enroll about 40 participants to see if the treatment can put the di…

This early-stage trial is testing a new vaccine designed to prevent serious cytomegalovirus (CMV) infections. The study involves patients with blood cancers who are receiving a stem cell transplant from a partially matched donor, a procedure that carries a high risk of CMV. Resea…

This study is testing a new vaccine approach to prevent a common and serious viral infection called CMV in patients receiving a stem cell transplant for blood cancers. Researchers are giving the vaccine to the healthy stem cell donors, hoping the donor's boosted immunity will be …

This study aims to find the best dose of N-Acetylcysteine (N-AC), a common supplement, to help reduce symptoms in people with myeloproliferative neoplasms (MPNs), a group of blood cancers. It will enroll 27 adults with ET, PV, or MF who have significant symptom burden. The main g…

This study aims to see if tracking the amount of a specific gene mutation (CALR) in a patient's blood over time can help doctors predict how their blood cell disorder will progress. It will follow 260 adults with these disorders for up to three years, collecting blood samples to …

This study aims to find out if specific markers in the blood can predict which patients with certain blood cancers are most likely to develop dangerous blood clots. Researchers will follow 300 patients for two years, taking blood samples to measure these markers. The goal is to b…

This study aims to understand how children's bodies process a liquid form of the cancer drug venetoclax, which is made by crushing tablets. It involves 30 children and young adults with blood cancers who cannot swallow pills and are already receiving this liquid medicine as part …

This study aims to learn how a specific type of immune cell, called a monocyte, behaves in people with certain blood cancers. Researchers will collect blood samples from 70 participants who have not yet started treatment for their condition. By analyzing these cells, they hope to…

This study aims to discover biological markers that can predict which patients with certain blood cancers will respond well to standard first-line treatments. Researchers will analyze blood samples from 120 adults with polycythemia vera, essential thrombocythemia, or pre-myelofib…

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This study is creating a large registry and tissue bank for children and young adults with cancer. It collects health information and leftover tissue samples from patients up to age 25 to help researchers understand these diseases better. The goal is to use this information to im…

This study aims to understand how the services from the nonprofit Blood Cancer United affect people with blood cancers. Researchers will follow 400 patients for six months to see if the organization's help improves their access to medical care, quality of life, and financial stre…

This study aims to understand why patients with a specific genetic mutation (CALR) in a rare blood cancer called MPN have a different risk of blood clots compared to patients with another common mutation (JAK2). Researchers will collect a single blood sample from about 35 adult p…