MYELOPROLIFERATIVE NEOPLASM

This study tests a vaccine designed to protect people who have had a stem cell transplant from a common virus called CMV. The virus can cause serious illness in those with weak immune systems. The vaccine uses a harmless virus to teach the body to fight CMV, aiming to reduce infe…

This study tests a drug called luspatercept in adults with lower-risk myelodysplastic syndromes (MDS) or related blood disorders who have anemia. The goal is to see if it can reduce the need for regular blood transfusions. Six participants will receive the drug along with standar…

This study tests a combination of three drugs (azacitidine, venetoclax, and pevonedistat) in adults with a newly diagnosed, aggressive form of acute myeloid leukemia (AML) that is either related to prior cancer treatment or developed from other blood disorders. The goal is to fin…

This study tests an experimental drug called INCB057643, given alone or with another drug (ruxolitinib), in people with myelofibrosis and other advanced blood cancers. The main goal is to check safety and see if it can reduce spleen size, which is often enlarged in these conditio…

This study tests whether adding a drug called cyclophosphamide after a stem cell transplant can reduce the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. The trial includes 35 adults with various blood cancers who are…

This study was designed to test a combination of two drugs (ASTX727 and ASTX029) in adults with certain types of blood cancers (MDS or MDS/MPN) that have a specific genetic change (RAS mutation). The goal was to find a safe dose and see if the combination could control the diseas…

This study tests whether adding special 'veto' cells to a stem cell transplant can help donor cells grow in the body without causing severe graft-versus-host disease (GVHD). It includes 16 people aged 12-75 with various blood cancers or bone marrow failure. The veto cells are tre…

This study tests a vaccine called Triplex to see if it can prevent cytomegalovirus (CMV) infection in adults who have received a stem cell transplant. CMV is usually harmless but can be dangerous for people with weakened immune systems. The vaccine uses harmless pieces of CMV DNA…

This early-phase study tests the safety of combining three drugs—navitoclax, venetoclax, and decitabine—for people with advanced myeloid blood cancers like leukemia and myelofibrosis. The goal is to find a safe dose that controls the disease. Sixteen adults aged 18 and older are …

This early-phase study tests a new targeted therapy called PVEK, which delivers chemotherapy directly to cancer cells, combined with a standard chemo regimen (FLAG-Ida) for adults with newly diagnosed high-risk acute myeloid leukemia (AML) and other aggressive blood cancers. The …

This study is for people newly diagnosed with a specific type of acute myeloid leukemia (AML) linked to prior cancer treatment or other bone marrow disorders. It tests whether adding the drug pomalidomide to standard chemotherapy can improve treatment results. About 50 adults wil…

This study tests a combination of two drugs, azacitidine and quizartinib, in 30 adults with certain blood cancers (MDS, MDS/MPN, CMML) that have specific gene mutations (FLT3 or CBL). The goal is to find the best dose and see how well the drugs control the cancer. This is not a c…

This study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections in the first 100 days while still preventing graft-versus-host disease. About 313 adults with various blood cancers…

This phase 2 trial tests whether adding venetoclax to the drug ASTX727 works better than ASTX727 alone for people with chronic myelomonocytic leukemia or related bone marrow cancers with too many immature cells. About 132 adults will receive either the combination or ASTX727 alon…

This study tests a drug called fedratinib in 25 adults with rare blood cancers (MDS/MPN and CNL). The goal is to see if it can shrink enlarged spleens and improve blood counts. Participants take the drug by mouth and are monitored for response and side effects.

This study looks at whether a special, quick brain MRI (called magnetic resonance fingerprinting) can detect changes in the brains of children and young adults (ages 0-30) with acute leukemia who are receiving chemotherapy. Participants will have brain scans and take a fun, game-…

This study is gathering information from 572 people in Italy with Philadelphia-negative myeloproliferative neoplasms (MPN), a group of rare blood cancers. Researchers are using surveys to measure how the disease and its treatments affect patients' well-being, symptoms, and daily …

This study looks at how common acquired pyruvate kinase deficiency is in people with certain blood cancers or pre-cancer conditions. Researchers will take a single blood sample from 100 participants to check for low enzyme activity or gene changes. The goal is to better understan…