New drug cocktail targets Hard-to-Treat blood cancers
NCT ID NCT03471260
First seen Oct 31, 2025 · Last updated May 23, 2026 · Updated 31 times
Summary
This study is for people with certain blood cancers (like leukemia) that have a specific genetic change called an IDH1 mutation. It tests a combination of two or three drugs: ivosidenib (targets the mutation), venetoclax (blocks a protein that helps cancer cells survive), and sometimes azacitidine (a chemotherapy drug). The goal is to find the best doses and see how well the combo works at shrinking or controlling the cancer. About 96 adults with relapsed, refractory, or newly diagnosed disease who cannot have standard chemo are being recruited.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center
RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Oregon Health and Science University
RECRUITINGPortland, Oregon, 97239, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Conditions
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