FATIGUE

This study tests whether taking sodium bicarbonate (baking soda) can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will take the supplement and undergo tests like e…

This study trains psychotherapists to give personalized talk therapy to cancer patients and their caregivers who are feeling very distressed. Therapists will learn several proven methods, like cognitive behavioral therapy and mindfulness, to help with anxiety, depression, pain, f…

This study tests if a safe, non-invasive brain stimulation technique called tDCS can reduce severe fatigue in people who have had a stroke. Participants will use a headset at home to deliver a mild electrical current to the front of the brain. The goal is to see if this treatment…

This study looks at whether exercise therapy and cognitive behavioral therapy (CBT) can reduce fatigue and improve treatment adherence in female breast cancer patients in Singapore. About 100 women who have completed surgery and chemotherapy will try these approaches. The goal is…

This study looks at whether a simple strength training program can help breast cancer survivors manage fatigue. Researchers want to see if the program works equally well for people from different income backgrounds. About 60 participants will follow a 3-month exercise guide and t…

This study tests a new treatment called transcranial pulse stimulation (TPS) for people with Post-COVID syndrome who suffer from fatigue, memory problems, or low mood. About 102 adults who had COVID-19 at least a year ago will get either real TPS or a sham treatment. The goal is …

This study tests whether taking a supplement called fisetin can reduce fatigue in older adults who have survived cancer. Researchers will enroll 60 people and measure changes in tiredness using a standard questionnaire. The goal is to find a safe, easy way to improve energy and q…

This study tests if a non-invasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) can reduce fatigue in people with multiple sclerosis (MS). Sixty participants with MS and moderate-to-severe fatigue will receive either real or sham (fake) r…

This study tests a wellness program for adults with cystic fibrosis who struggle with fatigue and poor sleep. About 80 participants will either join the program or continue their usual care. The program includes coaching sessions and uses a fitness tracker to monitor activity and…

This study is testing whether a focused muscle contraction exercise program can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Participants will complete 90 exercise sessions and 4 testin…

This study tests if aerobic exercise or cognitive behavioral therapy can reduce fatigue in people with myasthenia gravis. 60 adults with stable MG will be randomly assigned to one of these treatments or usual care. The goal is to see if these approaches improve fatigue and qualit…

This study tests two online programs designed to help people with multiple sclerosis (MS) manage their fatigue. About 2,000 adults with MS in the U.S. will be randomly assigned to one of the programs plus their usual care, or to usual care alone. The programs provide information …

This study tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue in people with sarcoidosis. It also looks at effects on anxiety and depression. About 100 adults with sarcoidosis and fatigue will either join the MBSR program or a mon…

This study tests whether walking exercise—done at a center or at home—can help reduce fatigue in older breast cancer survivors. About 24 women aged 60 and older who finished cancer treatment in the past year will take part. The goal is to find a simple, effective way to ease tire…

This study looks at whether a type of talking therapy (transdiagnostic cognitive behavioral therapy) can help reduce fatigue in primary care patients. About 190 adults aged 18-67 with severe fatigue lasting at least 3 months will be randomly assigned to either the therapy or usua…

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants must have poor sleep for at least 2 week…

This study tests whether using a simple stress ball during chemotherapy can help stomach cancer patients feel less nauseous, anxious, and fatigued. About 52 adults with stomach cancer will be asked to squeeze a stress ball while receiving treatment. Researchers will measure their…

This study tests whether a supplement called fucoidan, made from seaweed, can help reduce fatigue and inflammation in people who have finished cancer treatment. About 40 adult cancer survivors with ongoing fatigue will take the supplement for 8 weeks. The goal is to see if it's p…

This study looks at whether using the Calm meditation app for 10 minutes a day can help people with blood cancer who have trouble sleeping. About 276 patients will use the app for 8 weeks, and researchers will track their sleep, mood, fatigue, and signs of inflammation. The goal …

This study tests whether a special type of dynamic lighting can improve sleep, daily rhythms, and overall well-being in frail older adults (over 65) who are in the hospital. Researchers will measure changes in melatonin levels and sleep patterns. The goal is to see if adjusting l…

This study tests whether a non-invasive magnetic brain stimulation technique called rTMS can reduce fatigue in people who had a stroke more than six months ago. About 60 participants will receive rTMS, and researchers will track changes in fatigue, mood, and thinking. The goal is…

This study tests whether testosterone replacement therapy can reduce fatigue and improve sexual function in men aged 55 and older who have cancer and low testosterone. About 230 participants will receive either testosterone or a placebo for several months. The goal is to see if t…

This study aims to see if combining psychoeducational interventions (like counseling and self-help strategies) with an open-label placebo pill can improve fatigue and quality of life in people with metastatic cancer. The study will enroll 240 adults who have had significant fatig…

This study tests whether a special nutrient supplement (APPORTAL®), taken alongside standard exercise recommendations, can help reduce cancer-related fatigue in women with breast cancer who are undergoing chemotherapy. About 92 participants will receive either the supplement or a…

This small study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can reduce fatigue and other symptoms in people with post-COVID condition. Researchers will enroll 40 adults who have had symptoms like chronic tiredness for at least 12 week…

This study tests the safety of Niagen Plus, an injectable form of vitamin B3, in 40 healthy adults with fatigue. Participants receive injections under the skin or into muscle for about 100 days. Researchers check for side effects and measure NAD+ levels in the blood, which may he…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue and thinking problems in people with advanced cancer. About 40 adults with stage III or IV cancer will receive either modafinil or a placebo for a short time. The goal is to see if the…

This study tests a tele-exercise program called RISE-YA to reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants must be 6 months to 5 years past curative treatment and currently get little exercise. The program is delivered remote…

This study looks at whether low levels of immunoglobulins (antibodies) are a treatable cause of fatigue in people with multiple sclerosis (MS). Researchers will compare fatigue levels and infection rates in 106 MS patients with and without low antibody levels. The goal is to unde…

This study aims to uncover what causes and predicts fatigue in people with Sjögren's disease. About 100 adults will complete surveys and pain tests at the start and again after 3 months. The goal is to better understand fatigue to improve future care.

This study aims to understand the different types of fatigue people experience, whether from cancer, lupus, ME/CFS, or other conditions. Researchers will compare fatigued and non-fatigued adults using interviews, questionnaires, physical tests, and optional brain scans. The goal …

This study looks at the best ways to help people with physical disabilities stick to a home exercise program. Over 32 weeks, 257 participants will get access to exercise videos and wellness articles. Some will also receive health coaching calls, and if they aren't active enough a…

This study tests whether a weak electrical current applied to the neck or upper back can change how muscles work and how tired they get. Forty healthy adults aged 18 to 50 will take part in up to six sessions. Researchers will measure muscle force, effort, and activation to see i…

This study aims to understand why people with Long COVID (PASC) feel so fatigued. Researchers will use brain scans and effort-based tasks to compare 200 adults with PASC to healthy controls. The goal is to find brain changes that could lead to new treatments or rehabilitation str…

This study looks at how common sexual problems are in women with multiple sclerosis (MS) and how they connect to fatigue, depression, anxiety, bladder issues, and thinking problems. Researchers will survey 140 women with relapsing-remitting MS who have a regular partner and are s…

This study looks at why some people who have had a stem cell transplant continue to feel extremely tired and have trouble thinking clearly. Researchers will use brain scans and spinal fluid tests to see if inflammation in the brain is the cause. The goal is to better understand t…

This study will use smartphone recordings to measure common symptoms of myasthenia gravis, like slurred speech, voice changes, arm fatigue, and droopy eyelids. Researchers will compare 225 people with and without the condition to see if phone data can tell them apart. The goal is…

This study looks at how fatigue relates to muscle function in people with axial spondyloarthritis, a type of inflammatory arthritis. Researchers will measure exercise capacity and muscle strength in 122 adults starting a new targeted therapy. The goal is to better understand why …

This study looks at how often fatigue happens after a person's first stroke and what factors—like pain, mood, or sleep—make it worse. Researchers will follow 107 adults who had a stroke at least three months ago. The goal is to better understand post-stroke fatigue so doctors can…

This study looks at the connection between sleep quality and gum disease (periodontitis) in 48 healthy adults. Researchers will measure participants' sleep patterns, fatigue levels, and certain substances in saliva to see if poor sleep is linked to worse gum health. No treatments…

This study aims to understand how the brain decides how much effort to put into tasks, both mental and physical. Researchers will observe 185 healthy adults using brain scans and behavioral tests to see how fatigue and rewards change our perception of effort. The goal is to learn…

This study listens to cancer survivors to understand how they experience and talk about fatigue. Researchers will interview 80 survivors and their doctors to create a visual poster that helps patients describe their fatigue better. The goal is to improve communication and help pe…