ESSENTIAL TREMOR

This study tests a new type of brain stimulation using two leads instead of one to better control severe essential tremor. Ten adults who already have a standard deep brain stimulation (DBS) implant will receive the new dual-lead system. The goal is to see if it improves tremor c…

This study collects information from 500 people with essential tremor who receive a commercially approved deep brain stimulation (DBS) system. Researchers will track changes in quality of life over time using a standard questionnaire. The goal is to understand how well the device…

This study follows 1,000 people with Parkinson's disease, essential tremor, or dystonia who receive an Abbott deep brain stimulation (DBS) system. Researchers will measure changes in movement symptoms and track any serious side effects over five years. The goal is to confirm the …

This study tests deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia whose symptoms are not well controlled by medication. A small device, like a pacemaker, is placed in the chest and sends electrical signals to specific brain a…

This study tests whether a second focused ultrasound treatment on the opposite side of the brain helps people with essential tremor more than just one treatment plus standard care. About 100 adults with essential tremor will be randomly assigned to get either the second treatment…

This study tests whether a 3-D brain imaging technique called tractography can make focused ultrasound ablation more precise for people with essential tremor. About 24 adults with moderate to severe tremor that hasn't responded to medication will receive the procedure. The goal i…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose dystonia, a movement disorder. The goal is to see if the AI can correctly identify dystonia and reduce the time it takes to get a diagnosis. About 1,000 people w…

This study looks at how stereotactic radiosurgery (a precise type of radiation) affects quality of life and tremor severity in people with essential tremor or Parkinson's tremor whose medications aren't enough. About 60 participants will fill out questionnaires and have their tre…

This early-stage study tests whether repeated low-intensity focused ultrasound pulses can safely reduce tremors in people with essential tremor. Twenty adults will receive six treatment sessions over two weeks, with tremor severity measured before and after. The goal is to see if…

This study is testing a non-invasive ultrasound device (NaviFUS-ctbTUS) to see if it can safely reduce hand tremors in people with Parkinson's disease, essential tremor, or dystonic tremor. Twelve adults aged 18-80 who don't get enough relief from medication will receive the stim…

This study tests a new type of brain stimulation for people with essential tremor, a condition that causes shaking during everyday tasks like writing or holding objects. The treatment uses magnetic pulses to target two brain areas at once, aiming to reduce shaking better than sta…

This study tests whether a new drug called BP1.4979 can reduce tremors in adults with essential tremor, a condition that causes shaking hands. About 50 participants will take either the drug or a placebo twice daily for 4 weeks. Researchers will check tremor severity and safety t…

This study tests whether low-intensity focused ultrasound (LIFU) — gentle sound waves — can temporarily reduce tremors in people with essential tremor. Researchers will target specific brain areas and measure changes in tremor and brain activity. The goal is to understand brain c…

This study tests a new way to use deep brain stimulation (DBS) for essential tremor. Normally, DBS delivers constant electrical pulses to the brain, but over time this can lose effectiveness and cause side effects like numbness or speech problems. The new approach automatically t…

This study tests a new type of deep brain stimulation (DBS) for people with essential tremor, a condition that causes shaking hands. Instead of using constant high-energy pulses like standard DBS, the new method uses lower-energy patterns that may work better and have fewer side …

This study tests a prototype wearable device that uses gentle mechanical stimulation to reduce hand tremors in people with Essential Tremor or Parkinson's disease. About 80 adults with moderate to severe upper limb tremors will use the device at home over several weeks. The goal …

This study tests whether a newer, directional form of deep brain stimulation (DBS) can better control essential tremor while reducing side effects like speech and balance problems. About 24 adults with essential tremor will receive both directional and standard DBS to compare the…

This study follows 240 adults with essential tremor that doesn't improve with medication. They receive a non-invasive procedure called MR-guided focused ultrasound that targets a small area in the brain. Researchers will track tremor severity, side effects, and quality of life fo…

This study looks at brain activity related to speech in people with Parkinson's disease, essential tremor, or dystonia. Participants are already scheduled for deep brain stimulation (DBS) surgery. Researchers will record brain signals during speech tasks to better understand how …

This study looks at how a treatment called High-Intensity Focused Ultrasound (HiFU) changes brain activity in people with essential tremor, a condition that causes shaking. Ten adults over 50 who haven't been helped by standard medications will have their brain waves recorded bef…

This study is testing whether a simple skin biopsy can identify people with essential tremor who are at high risk of developing Parkinson's disease. Essential tremor affects millions, and about 1% of those with it develop Parkinson's each year. Researchers will follow 300 partici…

This study aims to make it easier for doctors to set up deep brain stimulation (DBS) devices for people with essential tremor. Researchers will use computer models to predict which stimulation settings will work best, reducing the trial-and-error process. About 25 adults with ess…

This study looks back at the medical records of up to 5,000 people who have or are eligible for deep brain stimulation (DBS) to treat Parkinson's disease, essential tremor, or dystonia. Researchers want to see how well DBS improves symptoms over time in everyday medical practice.…

This study is collecting information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are scheduled to receive a standard radiofrequency (RF) ablation treatment. The goal is to see how the procedure affects patients' quality of…

This study looks at how deep brain stimulation (DBS) affects attention and the way people with Parkinson's disease, essential tremor, or dystonia perceive facial expressions. Researchers will use eye-tracking and computer tasks to compare participants before and after DBS surgery…

This study looks at how alcohol affects tremors in people with essential tremor, dystonia, and Parkinson's disease. 45 participants will receive either an alcoholic drink or a non-alcoholic placebo on two separate days. Researchers will measure tremor changes using a device and c…

This study looks at how two brain circuits involved in movement and speech work when people learn new sound sequences. Researchers will temporarily turn deep brain stimulation (DBS) on or off in 80 adults with Parkinson's disease or essential tremor while they perform speech task…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse disorder. Researchers will measure brain responses and any changes in movemen…

This study looks at how deep brain stimulation (DBS) affects brain networks in people with essential tremor. Researchers will use EEG and MEG to record brain activity with the stimulator on and off, and also test other tremor-reducing methods like cooling the limb or medication. …