ESSENTIAL TREMOR

This study tests a new way to treat hand tremors caused by essential tremor or Parkinson's disease using focused radiation from a linear accelerator, instead of the usual Gamma Knife or brain surgery. The treatment is split into three sessions to protect healthy brain tissue whil…

This study tests a precise, non-invasive radiation treatment called frameless virtual cone radiosurgery for people with severe tremor from essential tremor or Parkinson's disease who cannot have deep brain stimulation. The goal is to reduce tremor and improve daily activities. Fo…

This study tests a new type of deep brain stimulator for people with essential tremor, a condition that causes uncontrollable shaking. Unlike standard devices that stimulate the brain constantly, this "closed-loop" system only delivers stimulation when it senses tremor activity. …

This study tests whether a new drug called ulixacaltamide can safely reduce tremors in adults with essential tremor, a condition that causes shaking hands. About 1,000 participants will receive either the drug or a placebo for up to 12 weeks, and then may join a longer safety stu…

This study tests whether a daily food supplement containing aldehyde dehydrogenase (ALDH) enzyme can reduce tremor severity and improve daily functioning in 40 adults with Essential Tremor. Participants take the supplement for three months, and researchers measure changes using s…

This study tests a wristband device called Cala TWO that uses nerve stimulation to help reduce hand tremors in people with essential tremor. About 20 adults who are already scheduled for deep brain stimulation surgery will use the device twice daily for three months. Researchers …

This study watches how deep brain stimulation (DBS) helps people with essential tremor over a day. About 50 participants will wear an Apple Watch and do simple tasks to see when the treatment stops working well. The goal is to learn if a smartwatch can measure this, not to change…

This study looks at how changing the timing of deep brain stimulation (DBS) pulses affects movement symptoms and brain activity in people with Parkinson's disease, essential tremor, multiple sclerosis, or dystonia. Researchers will test different stimulation patterns in 180 parti…

This study was designed to see if deep brain stimulation (DBS) of a brain area called VIM changes how people with essential or dystonic tremor breathe. Researchers planned to test breath-holding and peak airflow in a small group of patients before and after DBS surgery. However, …

This study aimed to test the safety and feasibility of a new imaging technique called Echo-Focusing for people with treatment-resistant brain disorders like essential tremor or depression. It planned to use sound waves to better visualize brain areas. However, the study was withd…

This study follows 100 people with essential tremor over about 5 years to learn more about different types of the condition and how it changes over time. Researchers will use brain scans, movement tests, and lab work to find markers that might help predict progression. The goal i…