Could a simple enzyme supplement calm essential tremors?
NCT ID NCT07238725
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a dietary supplement containing aldehyde dehydrogenase (ALDH) enzyme can ease tremors in people with essential tremor. Forty adults will take the supplement twice daily for three months. Researchers will measure changes in tremor severity and daily function using standard rating scales.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- aldehyde dehydrogenase (ALDH) enzyme dietary supplement
- What this could lead to
- If it works, this could point toward a simple dietary supplement to help reduce tremor severity and improve daily activities for people with essential tremor.
- What could go wrong
- This is a very early, small study with only 40 participants and no placebo group, so results may not be reliable or generalizable. The supplement may have no real effect on tremors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2025
- Expected to finish
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Feb 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged ≥ 19 years who provide written informed consent. * Diagnosed with Essential Tremor (ET) by a board-certified neurologist or neurosurgeon. * Presence of postural or intention tremor in the dominant hand/arm with a CRST score ≥ 2. * Stable medication regimen for at least 30 days prior to enrollment. * No structural brain abnormalities on MRI within the last 3 years. * Eligible according to investigator assessment and agreement by two clinical team members. Exclusion Criteria: * Presence of secondary tremor causes (e.g., Parkinsonism, dystonia). * Significant medical conditions such as severe arrhythmia, renal failure, hepatic failure, acute stroke, or epilepsy. * Contraindications to MRI (e.g., pacemakers, metal implants).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Korea University Anam Hospital
Seoul, 02841, South Korea
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