DOWN SYNDROME

This study tested the safety and effectiveness of tofacitinib, a drug that blocks certain immune signals, for treating skin conditions like eczema and psoriasis in people with Down syndrome. 47 adolescents and adults took part. The goal was to see if the drug could improve these …

This study looked at whether a simple blood test (NIPT) can safely replace the standard invasive test for Down syndrome in pregnant women at higher risk. Over 2,100 women were randomly assigned to either the blood test or the usual needle test. The goal was to see if the blood te…

This study tested whether playing active virtual reality games (exergames) is as good as or better than traditional aerobic exercise for improving physical fitness, daily function, and thinking skills in people with Down syndrome. 44 participants with mild to moderate intellectua…

This study looked at two therapies—orofacial therapy (exercises for the mouth and face) and therapeutic yoga—to see which better helps children with Down syndrome improve swallowing, sleep habits, and quality of life. Thirty children aged 5 to 12 took part. The goal was to find a…

This study tested whether a special diet and nutritional supplement could improve thinking, sleep, and overall health in people with Down syndrome, autism, or ADHD. 76 participants aged 2 to 35 followed the program for a set time. Researchers measured changes in executive functio…

This study tested a proactive speech therapy program called Babble Boot Camp for infants with Down syndrome, who often start talking much later than other children. Sixty babies under 12 months old took part, with their parents trained by a speech therapist via video calls. The g…

This study looked at whether people with Down syndrome can improve their spatial abilities—like mentally rotating objects or seeing another person's viewpoint—through practice with puzzles, blocks, and computer games. 84 adolescents and young adults with Down syndrome, along with…

This study looked at how exercise training changes blood flow and fitness in people with Down syndrome. Researchers measured work capacity, blood flow in the arms, and balance in 60 generally healthy but sedentary adults. The goal was to understand why people with Down syndrome o…

This study aimed to find early warning signs of obstructive sleep apnea (OSA) in people with Down syndrome, a condition where breathing stops and starts during sleep. Researchers studied 40 adults with Down syndrome using sleep tests and heart monitoring. The goal was to identify…

This study tested whether a 12-week online dance program is practical and enjoyable for young adults with Down Syndrome. Twenty participants took two 35-minute group dance classes each week. Researchers measured attendance, safety, and changes in fitness and thinking skills. The …

This study looked at whether a therapy called JASPER helps children with Down syndrome (ages 3-7) improve joint attention, play, and communication. Over 100 children and their caregivers took part, either receiving one-on-one coaching or a self-guided learning program. The goal w…

This study looked at whether using eye drops to widen the pupils (dilation) helps get a more accurate glasses prescription for people with Down syndrome. Many people with Down syndrome have unique eye shapes that standard eye exams may miss. The researchers compared glasses made …

This study interviewed 28 parents in Reunion Island who had a child with Down Syndrome to understand why they chose not to have a medical termination of pregnancy. Researchers wanted to learn about the cultural, family, and social reasons behind this decision. The goal is to bett…

This study tested an 8-week online nutrition education program for 31 people with Down syndrome and their 31 caregivers. The program aimed to improve eating habits and health. Researchers measured changes in diet, weight, and nutrition knowledge before and after the program.

This study developed a new questionnaire called the Down Syndrome Health Instrument (DHI) to measure health in people with Down syndrome. Researchers worked with over 750 caregivers, individuals with Down syndrome, and doctors to create and test the tool. The goal is to help iden…

This study looked at how young children with Down syndrome, cerebral palsy, or other motor delays first use mobility devices like body-weight support systems and powered chairs. Researchers measured how much space the children explored and their muscle activity during play. The g…

This study adapted a trunk control assessment (SATCo) into Turkish for infants with Down syndrome. Researchers tested 27 infants to see if the translated version is valid and reliable. The goal is to help therapists better track motor development in this group.

This study looked at 51 infants with Down syndrome, ages 7 to 36 months, to see how early motor skills (like reaching and crawling) affect their thinking, language, and use of gestures. Researchers observed babies during play and tested their development over time. The goal was t…