DOWN SYNDROME

This study tests a combination of two medicines (atomoxetine and oxybutynin) given at bedtime for 6 months to children with Down syndrome who have obstructive sleep apnea. The goal is to see if the treatment improves sleep breathing problems and thinking skills. The study involve…

This study tests a device that stimulates a nerve in the tongue to help with sleep apnea in 57 teens and young adults (ages 10-21) with Down syndrome. The goal is to see if better sleep from the device also improves thinking, attention, memory, and language skills over 12 months.…

This large study tests whether adding the drug blinatumomab to standard chemotherapy works better than chemo alone for children and young adults with newly diagnosed B-cell leukemia or lymphoma, including those with Down syndrome. The goal is to improve disease-free survival by h…

This study tests a modified chemotherapy plan for children with Down syndrome who are newly diagnosed with acute lymphoblastic leukemia (ALL). The treatment uses lower doses of certain drugs to reduce side effects while still fighting the cancer. About 60 children across Asia are…

This study tests three medications—lorazepam, IVIG, and tofacitinib—in 66 people with Down syndrome (ages 8-30) who have developed a serious condition called Down Syndrome Regression Disorder (DSRD). DSRD causes sudden loss of skills, catatonia, and other severe symptoms. The goa…

This large phase 3 study is testing different combinations and doses of chemotherapy drugs in over 9,000 children and young adults newly diagnosed with standard-risk B-cell acute lymphoblastic leukemia or localized B-cell lymphoblastic lymphoma. The goal is to find which treatmen…

This study explores whether short video clips recorded by parents on their smartphones can help identify children with Down syndrome who are at high risk for obstructive sleep apnea (OSA). About 141 children will participate. Parents will record their child sleeping and then gues…

This study looks at whether a liquid ADHD medication (methylphenidate) can improve thinking skills in children aged 6 to 17 who have both an intellectual disability and ADHD. The 68 participants will receive either the drug or a placebo, then switch after a break. Researchers wil…

This study looks at whether a specially designed group resistance training program (called RESID) can help adults with Down syndrome age in a healthier way. About 36 adults aged 20 to 45 with mild to moderate intellectual disabilities will take part, along with their caregivers. …

This study compares a new therapy—combining mild brain stimulation (tDCS) with virtual reality exercises—against standard physical therapy for 30 children aged 6-12 with Down syndrome. The goal is to see if the new approach improves balance, walking, thinking, and daily function.…

This study aims to develop a computer model that can predict how airway surgery will affect nighttime breathing in children with Down Syndrome who have obstructive sleep apnea. Researchers will measure airway resistance during a sleep MRI to improve the model. The study involves …

This study checks how well sleep questionnaires work for children with Down syndrome, who often have sleep apnea. About 81 children aged 2-17 will fill out surveys, and their results will be compared to a standard sleep test. The goal is to find a simple way to spot sleep problem…

This study looks at how often children with Down syndrome have problems in the neck part of the spine. Researchers at Sohag University Hospital will check 50 children aged 2 to 18 for symptoms and take X-rays to find any spine issues. The goal is to better understand these proble…