DOWN SYNDROME

This study tests a program called HomeGrown that helps families of young children with Down syndrome (ages 2-6) make healthy changes at home. The goal is to improve eating habits and physical activity. About 38 families will join a 6-month trial to see if the program is easy to u…

This study tests a drug called tofacitinib (XELJANZ) in 92 people with Down syndrome aged 6 to 22. The drug aims to calm the immune system and possibly improve thinking and daily skills. Participants receive either the drug or a placebo for 6 months, with close safety monitoring.

This study aims to improve treatment for obstructive sleep apnea (OSA) in people with Down syndrome by matching therapy to each person's specific cause of OSA. Researchers will compare a standard medication combination (atomoxetine and oxybutynin) with a personalized approach tha…

This study compares personalized surgery guided by a sleep endoscopy to standard tonsillectomy for treating obstructive sleep apnea in 303 children with Down syndrome, ages 2 to 17. Sleep apnea is very common in these children and often doesn't improve with standard treatments. T…

This study tests whether adding nivolumab to blinatumomab works better than blinatumomab alone for children and young adults (ages 1 to 30) whose B-cell acute lymphoblastic leukemia (B-ALL) has returned after initial treatment. Participants include those with Down syndrome. The g…

This study is the first time the drug Leucettinib-21 is being tested in humans. It will check the drug's safety in healthy volunteers and in people with Down syndrome or Alzheimer's disease. The goal is to see if the drug is safe and how the body processes it, which is a step tow…

This study tests a program called PACE that helps adults with intellectual disability become more physically active. About 120 adults, their caregivers, and coaches will take part. The program focuses on increasing daily steps and moderate-to-vigorous activity to improve overall …

This study tests whether levetiracetam, a seizure medication, can prevent epileptic seizures in adults over 40 with Down syndrome who also have Alzheimer's disease. 120 participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop se…

This study looks at whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. About 81 participants without dementia will either follow a reduced-calorie diet with monthly coaching or attend general health education sessions. Over 12 months…

This study compares two types of exercise programs—Cuevas Medak Exercises and Rebound Exercises—to see which better improves physical fitness in children with Down syndrome. Twenty-two children aged 3 to 8 will participate in 12 weeks of supervised sessions. The goal is to find a…

This study looks at whether using a powerball (a spinning hand exercise device) on a stable surface versus an unstable surface (like a BOSU ball) can improve arm endurance and coordination in children with Down syndrome. 28 children aged 6-10 will do 30-minute sessions three time…

This study looks at whether Vojta therapy can improve how children with Down syndrome walk and move. 28 children aged 2 to 10 will be split into two groups: one gets Vojta therapy, the other does not. Researchers will measure changes in walking patterns and overall movement befor…

This study tests a special nasal device (ssNPA) to see if it can help children with weak throat muscles breathe easier during sleep. About 40 children with obstructive sleep apnea will try the device overnight. The goal is to reduce breathing pauses and improve sleep quality, wit…

This study looks at whether drumming lessons can boost self-control and timing skills in children with Down syndrome. Thirty kids aged 7 to 15 will take two months of lessons from a professional drummer. Researchers will measure changes in behavior and brain activity using comput…

This study looks at whether the OTAGO exercise program can improve balance, walking endurance, and motor coordination in children with Down syndrome. Researchers will work with 30 children aged 8 to 14 who have mild to moderate intellectual disability. The children will do the ex…

This study looks at whether jumping rope can improve foot posture in children with Down syndrome who have flat feet. Researchers will split 32 children aged 4 to 15 into two groups: one will jump rope and play, the other will just play. Foot changes will be measured before and af…

This study tests whether playing a bean bag tossing game on a wedge or a balance board can improve balance and walking in children with Down syndrome. Thirty-six children ages 7-12 will play the game three times a week for four weeks. Researchers will measure changes in static an…

This study aims to help young people with Down syndrome (age 12 and older) and their caregivers sleep better and feel better. Researchers will adapt a virtual mindfulness program for insomnia and test it in a small trial with 20 participants. The goal is to see if the therapy imp…

This study uses special eye scans to look for early signs of brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will examine the tiny blood vessels and layers in the eyes of 2,000 adults—both healthy and with brain conditions—to see if eye changes c…

This study looks at medical records of 1000 children with conditions like autism, epilepsy, and Down syndrome to find common biological patterns. Researchers want to understand what causes these disorders and how children respond to treatments. The goal is to improve diagnosis an…

This study enrolls up to 550 adults with Down syndrome, ages 25-55, to track their thinking skills, genetics, and brain changes over time. The goal is to understand how Alzheimer's disease develops in this group and to create a pool of volunteers ready for future prevention trial…

This study explores whether gentle light, sound, and vibration can safely change brain waves in adults with Down syndrome, who have a higher risk of Alzheimer's disease. Researchers will measure brain activity with EEG during a single 30-60 minute session. The goal is to see if t…

This study looks at how the autonomic nervous system (which controls heart rate and blood pressure) works in people with Down syndrome. Researchers will measure heart rate, blood pressure, and stress hormones during activities like cold exposure, fear simulations, and exercise. T…

This study measures immune markers (like antibodies and white blood cells) and breathing rates in 40 children with Down syndrome who have pneumonia. Researchers want to see if there is a link between the immune system and how well the children breathe. No treatment is given—this …

This study is creating a large collection of biological samples (like blood, saliva, and urine) from people with and without Down syndrome, ages 6 months to 89 years. The goal is to help researchers better understand Down syndrome and the health problems that often come with it. …

This study looks at the long-term health of children and young adults with Down syndrome who have been treated for acute leukemia. Researchers want to understand what chronic health problems they may face after cancer treatment. By gathering this information, they hope to create …

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…

This study follows 700 people with Down syndrome (and some healthy relatives) for up to 15 years to understand how their immune system changes over time. Researchers will check for infections, autoimmune problems, and cancers, and see if having part of the thymus removed during h…