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Exercise study reveals how blood flow works in down syndrome

NCT ID NCT04854122

Knowledge-focused Sponsor: University of Nevada, Las Vegas Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how exercise training changes blood flow and work capacity in 60 adults with Down syndrome. Participants were generally healthy but sedentary. The goal was to understand if exercise can improve how the heart and blood vessels work during activity. Results may help design better fitness programs for this group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Sep 2021

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * generally healthy * sedentary (defined as being involved in less than 30 minutes of moderately-intense physical activity per day) * additionally for the participants with Down syndrome: * diagnosis of Down syndrome trisomy 21 and * normal thyroid function or stable thyroid function (and medications) for at least 6 mo. Exclusion Criteria: * congenital heart disease; * atherosclerotic or other vascular disease; * asthma or other pulmonary disease; * hypertension (defined BP \>140/90 mmHg); * blood pressure below 90/60 mmHg; * history of pre-syncope or syncope; * diabetes (defined as Hba1c of \>7.5% or use of glucose lowering medication); * severe obesity (defined as BMI \>40); * medications affecting heart rate, blood pressure or arterial function; * anti-inflammatory medication including NSAIDS; * current smoking and * pregnancy.

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Conditions

The condition(s) this trial relates to.

Down syndrome Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Down syndrome

Contacts and locations

Locations

  • University of Nevada, Las Vegas

    Las Vegas, Nevada, 89154, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.