DIABETES

This study tests whether a natural compound called maslinic acid, found in olives, can safely improve metabolic health in 50 Chinese adults with excess weight or early signs of metabolic syndrome. Participants take the supplement for 12 weeks while researchers measure changes in …

This study tests whether giving people free boxes of fruits and vegetables along with nutrition tips can help manage conditions like diabetes, high blood pressure, and obesity. About 300 adults from three Mississippi counties with high poverty and health disparities will take par…

This study looks at how well the Joslin Why WAIT? program works for people with type 2 diabetes and a BMI over 35. The program focuses on weight loss and intensive treatment to improve health. Researchers are measuring weight loss, blood sugar control, and cholesterol levels in 1…

This study looks at whether adding a low dose of the diabetes medication insulin detemir to a low-calorie diet helps people with obesity and type 2 diabetes lose more weight and improve brain function related to food reward. 240 adults aged 31-60 will be randomly assigned to eith…

This study looks at whether having a cancer survivor's regular doctor work closely with their cancer team can better manage heart-related conditions like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers (like breast, prostate, or lung) an…

This study compares two treatment plans for people who develop diabetes from taking steroids. One plan uses a combination of a GLP-1 receptor agonist and long-acting insulin, while the other uses standard intensive insulin therapy. The goal is to see which approach better control…

This study looks at whether treating people with conditions like heart failure, infections, or diabetes at home (instead of in the hospital) can lead to better health and happier patients. About 9,600 adults will take part, receiving hospital-level care in their own homes. Resear…

This study tests a culturally tailored support program for 300 Chinese and Korean American caregivers of relatives with dementia. The program combines counseling with online peer support groups to reduce stress, depression, and health risks like diabetes and heart disease. Resear…

This study compares a new once-weekly insulin (GZR4) to a standard daily insulin in 580 adults with type 2 diabetes who already use mealtime insulin. The goal is to see if the weekly shot controls blood sugar just as well, with fewer injections and similar safety. Participants wi…

This study compares a new diabetes-specific nutritional formula to an existing one in 103 adults with type 1 diabetes, type 2 diabetes, or prediabetes who are at risk for malnutrition. The goal is to see if the new formula is as good as the current one at improving nutrition, mea…

This study tests a new insulin called GZR4 that is given just once a week, compared to a standard daily insulin, in 620 adults with type 2 diabetes. The goal is to see if the weekly shot controls blood sugar just as well or better, with fewer injections and similar safety. Partic…

This study looks at whether giving people with obesity and diabetes a monthly $160 subsidy for fruits and vegetables helps them buy more healthy food. 214 adults will be split into groups, some getting the subsidy and some not, for 3 months. Researchers will track how much produc…

This study tests a program where community paramedics visit adults with diabetes who have had severe low blood sugar (hypoglycemia). The goal is to help them better manage their diabetes, prevent future emergencies, and improve their quality of life. The program involves educatio…

This study tests a new insulin called GZR4 that is given once a week, compared to a daily insulin shot (glargine) plus other diabetes pills. About 580 adults with type 2 diabetes who have never used insulin before will take part. The goal is to see if the weekly shot works as wel…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits. About 49 adults who had a kidney transplant in the past year and have high blood pressure, hi…

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to diabetes and high blood fats. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…

This study gives the drug metreleptin to people with partial lipodystrophy, a rare condition that causes abnormal fat storage, high blood fats, and diabetes. Participants have already shown improvement from metreleptin in earlier studies and cannot get the drug elsewhere. The goa…

This study tests whether pharmacists can help people lower their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity will receive pharmacist-led support. The goal is to see if this approach reduces overall cardiovascular risk wi…

This study evaluates a home collection kit that lets people with diabetes mail in a small blood sample to check their HbA1c levels, a key marker of blood sugar control. About 63 adults with Type 1 or Type 2 diabetes will try the kit and give feedback. The goal is to see if the ki…

This study looks at whether giving extra support—like phone calls and more resources—to people who aren't losing weight early in a diabetes prevention program can help them succeed. It involves 403 Black adults without diabetes who are overweight. The goal is to prevent diabetes …

This study looks at whether taking a daily extract of yerba mate (a traditional South American drink) can improve health markers like weight, blood sugar, and cholesterol in overweight adults. Eighty people aged 40-65 will take either the extract or a placebo for 90 days. Researc…

This study tests a new way of caring for children under 10 with diabetes. The clinic uses play, calmness training, healthy lifestyle advice, and parent support groups to improve quality of life for both kids and their families. About 100 children and their parents will take part …

This study looks at whether a mindfulness-based stress reduction program and yoga can lower stress, improve quality of life, and help control blood sugar in teenagers with type 1 diabetes. About 90 teens aged 13-18 will take part. The goal is to see if these mind-body practices c…

This study tests whether using game-like rewards and personal coaching can help older adults (50+) become more active after leaving the hospital. About 350 participants with conditions like high blood pressure or heart failure will wear a Fitbit to track steps. The goal is to see…

This study looks at 40 young boys who play soccer—some have type 1 diabetes, some don't—to see how their bodies differ in muscle, fitness, and temperature control during exercise. Researchers will use thermal cameras and continuous glucose monitors to track changes in real time. …

This study is creating a large biobank of 48,000 people with diabetes in Hong Kong. Researchers will collect blood samples and health data to find genetic markers that predict serious complications like kidney failure, heart disease, and stroke. The goal is to improve early detec…

This study aims to understand why people of African ancestry have high rates of type 2 diabetes, obesity, and heart disease. Researchers will collect blood samples and health information from 1,100 adults who identify as African American, Afro-Caribbean, or migrants from sub-Saha…

This study looks at whether using a Fitbit and a continuous glucose monitor is a practical way to track daily exercise in people with cancer or diabetes. About 35 adults who are not very active will wear these devices for a period of time. The goal is to see if people are willing…

This study looks at how certain immune proteins, called the complement system, may make kidney disease worse in people with diabetes. Researchers will measure these proteins in blood and urine from 90 participants to see if they are linked to kidney damage and blood vessel health…

This study follows about 3,000 adults in Port-au-Prince, Haiti, for up to 7 years to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other problems. Participants give blood, stool, a…

This study aims to discover new biological markers (called microRNAs) in the blood that could help identify and understand Adult Onset Autoimmune Diabetes. Researchers will collect blood samples from 25 adults with type 1 diabetes to look for changes in these markers. The goal is…

This study is a review of many smaller trials that looked at what happens when people replace animal proteins (like meat, dairy, eggs) with plant proteins (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weigh…

This study tests a new way of organizing care for chronic diseases like high blood pressure, diabetes, and kidney disease in Thailand. Researchers will work with 16 primary care clinics to see if using patient data in real time helps doctors and nurses provide better care. The go…

This study looks at adults with cystic fibrosis to understand how having diabetes impacts their quality of life, lung function, and nutrition. Researchers will compare those with and without diabetes using questionnaires and breathing tests. The goal is to gather information to i…

This study aims to understand how bariatric surgery improves the way the body handles sugar and fat. Researchers will collect tissue and blood samples from 500 people having weight-loss surgery or other procedures. By studying these samples, they hope to learn the molecular signa…

This study looks at whether using a fast, on-the-spot test for blood sugar control (HbA1c) and kidney function (cystatin C) at outpatient clinics can improve long-term diabetes outcomes. About 222 adults with diabetes will take part. The goal is to see if quick results help docto…

This study follows 600 people with and without chronic kidney disease (CKD) for up to 4 years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that may lead to thinking problems in CKD patients. Participan…

This study looks at how a single dose of the experimental drug GZR4 injection behaves in the body of people with mild, moderate, or severe liver impairment compared to those with normal liver function. The goal is to understand safety and how the drug is processed. 36 adults with…

This long-term study follows thousands of Black and white adults in Baltimore to understand how race and income influence health as people age. Researchers collect health data, including heart and brain health, through exams and surveys over many years. The goal is to uncover why…

This study tests different ways to invite adults with diabetes to meet with a pharmacist for medication support. About 590 participants will receive different letters and phone call schedules to see which approach works best. The goal is to find a simple, repeatable method that c…

This study looks at how COVID-19 may change organs like the heart, lungs, or kidneys in people who have diabetes and those who don't. Researchers will use scans to measure organ size and other changes in 35 adults who had COVID-19. The goal is to learn more about long-term effect…

This study aimed to see if people with diabetes have slower stomach emptying after fasting, which could raise the risk of complications during surgery. Researchers planned to use ultrasound to compare stomach contents between diabetic and non-diabetic patients before scheduled va…