DIABETES

This study looks at whether a tighter blood sugar target (70-140 mg/dL) can improve diabetes control in 120 children and teens with Type 1 Diabetes who use automated insulin pumps. Participants will be randomly assigned to either the standard target or the tighter target for 12 m…

This study tests a 6-week program for older adults (55+) who have both diabetes and mild memory or thinking problems. Participants attend weekly group sessions with their caregiver to learn better diabetes self-care. The goal is to see if the program improves blood sugar control …

This study tests whether an AI-powered tool can help community doctors improve control of high blood pressure, diabetes, and high cholesterol in 6,800 adults. Participants will be randomly assigned to either AI-assisted care or usual care. The goal is to see if the AI helps more …

This study tests whether empagliflozin, a diabetes drug, can improve blood sugar control in people who have had islet transplants but still have partial pancreas function. About 40 adults will take either a placebo or one of two doses of the drug for 3 months. The goal is to see …

This study looks at the safety and performance of the Endogenex System in 50 adults with type 2 diabetes. Participants previously received a sham (fake) procedure in an earlier study. The goal is to see if the device is safe and works well for managing diabetes.

This study will give 4,450 low-income adults with diabetes or hypertension a monthly food card benefit of either $80 or $120. Researchers want to see if the extra grocery support helps reduce food insecurity and improves key health measures like blood sugar and blood pressure. Pa…

This study tests whether group care—where patients meet together with a healthcare provider for education and check-ups—can help control high blood pressure and diabetes better than standard one-on-one visits. About 1,110 adults in Nepal will take part, with some receiving group …

This study looks at whether a continuous glucose monitor (CGM) can safely guide insulin therapy in cancer and transplant patients who are not in the ICU but need IV insulin due to steroids and specialized nutrition. About 80 adults with diabetes will be randomly assigned to eithe…

This study looks at whether sending reminders by text, email, or patient portal messages helps people with heart disease or diabetes refill their statin prescriptions. About 22,000 adults will receive different types of outreach or usual care, and researchers will track who refil…

This study looks at whether adding a supplement called HMB to an exercise program can improve muscle mass, strength, and blood sugar control in older adults (ages 60-80) with type 2 diabetes and low muscle mass. Participants will be randomly assigned to exercise, HMB, both, or pl…

This study looks at whether a GLP-1 RA drug (used for diabetes and weight loss) can improve fat levels in the liver and blood of people with MASLD (fatty liver disease). About 30 adults with MASLD, diabetes, and obesity will take the drug and have liver biopsies and blood tests t…

This study tests Mobili®, a portable digital dispenser that gives the right pills at the right time, to help people with multiple chronic diseases stick to their medication schedule. About 96 adults with diabetes or heart disease who take at least two daily oral medications will …

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are overdue for screening will try the program, which offers options like self-collection for HPV testing. The goal is to see if the program i…

This study looks at whether pregnant women with type 1 or type 2 diabetes can safely keep using their insulin pump during labor instead of switching to IV insulin. About 30 women who already use an insulin pump will be allowed to continue using it while giving birth. The goal is …

This study tests if a mild electrical pulse to the ear can stimulate the vagus nerve and reduce nausea, vomiting, and stomach pain in people with diabetes and gastroparesis. Researchers will enroll 60 adults who have had gastroparesis for at least a year. The goal is to see if th…

This study tests whether the drug sodium phenylbutyrate (NaPB) can improve blood pressure and blood vessel function in people with diabetes. Researchers will compare results from 30 healthy volunteers and diabetes patients. The goal is to see if NaPB can ease vascular problems li…

This study tests a 12-week home-based exercise program for adults aged 60+ with type 2 diabetes and early muscle weakness (probable sarcopenia). Participants will do short bouts of aerobic and resistance exercises to see if it improves their physical activity levels and muscle st…

This pilot study will test if a program that provides education, motivation, and social support can help prevent kidney disease from worsening in 50 adults with diabetes and early-stage chronic kidney disease. Participants will meet virtually with a nurse and complete surveys ove…

This study will collect health information and samples (blood, saliva, urine, stool) from up to 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or metabolic problems. Researchers want to learn how diabetes and obesity develop and change over many years. Parti…

This study tests a method called 'audit and feedback' to help primary care providers follow best practices for high blood pressure and diabetes. Researchers will give some providers reports on how well they are doing and compare their care to providers who get no feedback. The go…

This study is testing a new AI-powered tool called AIManage that helps doctors and patients manage medications for diabetes and obesity. The tool will provide guidance on adjusting doses. The study involves 16 participants and will first gather feedback on how useful and easy the…

This study looks at whether a special phone app can reliably send blood sugar readings from children with diabetes to the hospital's computer system. Currently, these readings are only available on a bedside device or phone app, not to the care team in real time. The study will e…

This study looks at how meals with different amounts of fat, carbs, and protein change fat levels in the blood. Researchers will study 100 adults with conditions like diabetes, metabolic syndrome, or kidney disease, plus healthy volunteers. Participants will eat two different bre…

This study looks at how clinics can better identify physically inactive patients and refer them to community-based exercise programs. Researchers will track how many patients get referred and whether a 12-week program improves their activity levels and health. The goal is to make…

This study is testing a new, noninvasive device called the Argus CGM that uses light and AI to estimate blood sugar levels without needles or skin punctures. Up to 100 adults with type 1 diabetes, type 2 diabetes, or prediabetes will wear the device for 15 days while researchers …

This study will collect health information from 10,000 adults with diabetes, metabolic disorders, or related conditions like high blood pressure and fatty liver. Researchers will track things like blood sugar, weight, and lab results over at least 10 years to find better ways to …

This study looks at whether having a team of heart experts discuss treatment decisions in real time during a procedure can improve outcomes for people with diabetes and severe blockages in all three main heart arteries. About 1,350 participants will be randomly assigned to either…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—this is an observation-only study to better understand the…

This study looks at how healthy, non-diabetic adults from the Old Order Amish community respond to sitagliptin, an FDA-approved diabetes medication. Over 7 weeks, participants will have two clinic visits where they drink a sugary solution and give blood samples to measure insulin…

This study will enroll 20 severely obese adults who are scheduled for weight-loss surgery. Half will use a continuous glucose monitor (CGM) and the other half will use standard finger-prick testing to check their blood sugar. The goal is to see if CGM helps reduce blood sugar swi…

This study collects blood samples from 30,000 adults in the UK with various health conditions, such as blood clots, infections, heart disease, and diabetes. The samples are used to develop and fine-tune new diagnostic tests that can be done right at the patient's bedside. The goa…

This study looks at 100 adults who had a stroke caused by a large blood clot in the front part of the brain and underwent a procedure to remove it. Researchers will use a special ultrasound (transcranial Doppler) to measure blood flow in the brain after the procedure. The goal is…

This study is a registry that collects long-term safety information from people with type 2 diabetes who have already been treated with the Endogenex System. Researchers will track device- and procedure-related side effects over time. About 500 participants will provide their med…

This study tests whether community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. CHWs will work one-on-one with participants to create personalized health plans and teach …