COLORECTAL CANCER (CRC)

This study tests a new drug, tegavivint, in people with metastatic colorectal cancer that has worsened after at least two prior treatments. The goal is to find a safe dose and see if the drug, alone or with standard therapies, can shrink tumors. About 126 adults with specific gen…

This study tests an experimental drug called RMC-6236 in about 754 adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have specific RAS gene mutations. The main goals are to check safety and find the right dose. This is an early-phase trial, so it foc…

This early-stage study tests a new drug called KO-2806 in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find safe doses and see if the drug can shrink tumors when used alone or with other cancer medicines. About 300 participan…

This study tests a combination of two treatments (fruquintinib plus FOLFIRI) in people with metastatic colorectal cancer whose disease has worsened after first-line therapy. About 60 participants will receive the drug combo to see if it can stop or slow cancer growth. The goal is…

This study tests a two-part approach for people with advanced solid tumors that cannot be removed by surgery. First, a radioactive tracer helps doctors see the tumor on scans. Then, a therapeutic dose of radiation is given to destroy cancer cells. The goal is to find the safest a…

This early-phase trial tests a new drug called TH9619 in 43 adults with advanced solid tumors (colorectal, head and neck, lung, or stomach cancer) that have not responded to prior treatment. The main goal is to find a safe dose and check for side effects. Researchers will also wa…

This study tests a new experimental drug (ABT-301) combined with two existing cancer treatments (tislelizumab and bevacizumab) in people with a specific type of advanced colorectal cancer that has not responded to at least two prior therapies. The goal is to find the safest and m…

This study tests a new drug called RMC-5127 in people with advanced solid tumors that have a specific KRAS G12V gene change. The drug is given alone or with other medicines to see if it is safe and can shrink tumors. About 574 adults who have already tried other treatments will t…

This study tests whether adding an immunotherapy drug (PD-1 monoclonal antibody) and bevacizumab to standard chemotherapy helps shrink tumors before surgery in people with a specific type of advanced colorectal cancer (pMMR/MSS). About 166 participants will be randomly assigned t…

This early-stage study tests a new drug called CBI-1214 in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 80 participants will receive the drug through an IV, and r…

This study tests a combination of experimental drugs (RAS(ON) inhibitors plus ivonescimab) in adults with advanced solid tumors that have a RAS mutation. The goal is to see if the combination is safe and can shrink or control tumors. About 370 participants whose cancer has worsen…

This study tests a new treatment called CAR-T cell therapy for people with advanced colorectal cancer that hasn't responded to standard treatments. The therapy uses a patient's own immune cells, modified to target two proteins (CDH17 and GUCY2C) found on cancer cells. The goal is…

This program provides early access to two investigational immunotherapy drugs, botensilimab and balstilimab, for people with serious or life-threatening cancers such as colorectal, pancreatic, lung, liver, melanoma, sarcoma, ovarian, or prostate cancer. It is for patients who hav…

This study is testing a new experimental drug called BMS-986523, given alone or with other cancer medicines, in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety and find the right dose. About 252 adult…

This study tests a new drug called HLX43 in 60 adults with advanced colorectal cancer that has stopped responding to standard treatments. The drug is designed to attach to a protein on cancer cells and deliver a toxic payload to kill them. The main goal is to find the best dose a…

This early-stage trial tests a new drug called XL092, alone or with other immune-boosting drugs, in people with advanced solid tumors that have stopped responding to standard treatments. The goal is to find safe doses and see if the combination can shrink tumors or slow their gro…

This study looks at whether a blood test that detects tumor DNA (ctDNA) can help doctors decide on the best chemotherapy for people with stage I or low-risk stage II colorectal cancer after surgery. About 80 participants who test positive for ctDNA one month after surgery will re…

This study tests a new approach for people with a common type of locally advanced rectal cancer. Participants receive a single low dose of radiation, followed by a combination of an immunotherapy drug (pucotenlimab) and chemotherapy (CAPEOX) before surgery. The goal is to see if …

This early-phase study tests a new drug called OKN4395, alone or with an immunotherapy (pembrolizumab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find safe doses and see if the drug can shrink tumors. About 166…

This study tests a new drug called JYP0015 in adults with advanced solid tumors that have a specific genetic change called RAS mutation. The goal is to see if the drug is safe and can shrink tumors. About 210 people with pancreatic, lung, or colorectal cancer will take part.

This study is looking for 400 adults in Portugal, aged 40 to 74, who have recently been diagnosed with colorectal cancer but haven't started treatment yet. Researchers want to see if analyzing the bacteria in a person's stool can help detect cancer earlier and predict outcomes. T…

This study is testing whether a simple, at-home stool test (FIT) can accurately detect if bowel cancer has returned after surgery. About 1,000 patients who had bowel cancer surgery will provide a stool sample before their routine 3-year colonoscopy. If the FIT test proves reliabl…

This study collects blood samples from 1,300 people in the U.S. to improve a test that looks for DNA markers of colorectal cancer and advanced adenomas (precancerous growths). Participants include those newly diagnosed with colorectal cancer or advanced adenomas, as well as peopl…

This study is testing a new blood test called Delta-HLD to see how well it can detect colorectal cancer in average-risk people aged 45 to 75 who are already scheduled for a screening colonoscopy. The colonoscopy results will be used as the gold standard to compare the blood test'…

This study tests whether a digital support program can help people with breast, prostate, or colorectal cancer reduce the time they spend sitting during their treatment. The goal is to improve their well-being and lower future health risks. About 172 participants will be randomly…

This study looks at whether proteins in urine can help doctors predict how patients with advanced colorectal cancer will respond to treatment before surgery. Researchers will collect urine samples from 400 participants and use advanced technology to find protein patterns linked t…

This study looks at how two types of anesthesia (total intravenous vs. inhaled) affect muscle loss in 40 adults undergoing colorectal cancer surgery. Researchers will measure muscle mass and strength before and after surgery using ultrasound, grip strength tests, and body composi…

This study looks at bacteria in stool samples from 30,000 people aged 40-74 in Portugal to find new markers for early colorectal cancer detection. Researchers will compare gut microbiome patterns with standard screening tests and colonoscopy results. The goal is to develop a more…

This study looks at whether people hospitalized with a blood infection caused by certain gut bacteria might have undiagnosed colon cancer or precancerous growths. Participants will swallow a small camera (colon capsule endoscopy) a few weeks after leaving the hospital to check th…

This study is gathering detailed information from 625 people with colorectal or pancreatic cancer that has spread to the liver, as well as from healthy volunteers. Researchers will analyze tumor and blood samples to understand how the immune system interacts with these cancers. T…