COLORECTAL CANCER (CRC)

This study tests whether an injectable drug called IP-001, given right after standard heat-based liver tumor ablation, can help prevent colorectal cancer from coming back in the liver or spreading elsewhere. About 717 adults with colorectal cancer that has spread only to the live…

This study tests an experimental drug called BPI-572270 in 120 adults with advanced solid tumors (lung, colorectal, or pancreatic cancer) that have specific RAS gene mutations. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. Participan…

This early-phase study tests a new daily pill, KQB368, in adults with advanced solid tumors that have specific KRAS mutations (G12S or G12C) and no standard curative options. The main goals are to find a safe dose and see if the drug can shrink tumors. About 48 participants will …

This study tests whether adding lubiprostone to standard maintenance therapy can delay cancer recurrence in people with colorectal cancer that has spread to the lining of the abdomen (peritoneum). About 124 adults who have had surgery to remove visible tumors will be randomly ass…

This study focuses on American Indian adults aged 45 to 75 who are eligible for colorectal cancer screening. The goal is to increase the number of people who complete a diagnostic colonoscopy within 60 days after a positive screening test. Researchers will work closely with triba…

This study looks at whether taking magnesium by mouth and soaking feet in a magnesium solution can reduce nerve pain and improve sleep in people with colorectal cancer getting chemotherapy. About 75 adults will be split into three groups: one gets magnesium pills, another gets pi…

This study tests a non-invasive device called transcutaneous electrical acustimulation (TEA) in 190 elderly patients (65+) recovering from colorectal cancer surgery. The device delivers mild electrical pulses to the skin to stimulate bowel function. Researchers will compare TEA t…