COLORECTAL CANCER (CRC)

This study offers ongoing treatment with ruxolitinib (alone or with other cancer therapy) to people with pancreatic, colorectal, breast, or lung cancer who were already benefiting from it in a previous Incyte study. It includes up to 10 participants and focuses on tracking side e…

This study tests a low-dose immunotherapy (nivolumab or pembrolizumab) in 30 people with a specific type of advanced colorectal cancer (MSI/dMMR). The goal is to see if 6 months of treatment can make the tumor disappear or shrink enough to avoid surgery. Participants have stage I…

This early-phase study tests a new drug called RMC-6291 in adults with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to find a safe dose and see how the body handles the drug. About 222 people with lung, colorectal, or pancreatic cancer that has not r…

This study tests an experimental antibody called GEN1042, alone or with the cancer drug pembrolizumab (with or without chemotherapy), in people with advanced solid tumors like lung, colon, melanoma, head and neck, or pancreatic cancer. The goal is to see if the treatment is safe …

This study compares two at-home stool tests—Cologuard and FIT—mailed to adults aged 45-49 who are due for colorectal cancer screening. Researchers want to see which test leads to more people completing screening. About 400 participants from the UCSD Health system will take part, …

This study looks back at data from 128,000 people in Germany who had surgery for colorectal cancer. It compares robot-assisted surgery to standard laparoscopic (keyhole) surgery to see which one leads to fewer problems and better long-term survival. The goal is to find out if usi…