COLORECTAL CANCER (CRC)

This is the first study in humans testing a new drug called KO-2806, both alone and combined with other cancer therapies. It aims to find safe doses and see early signs of effectiveness in 300 adults with advanced solid tumors that have specific genetic changes, including certain…

This study is testing a new oral medication called RMC-6236 in adults with advanced solid tumors that have specific mutations in a gene called RAS. The main goals are to find a safe and effective dose and to see if the drug can help control cancers like non-small cell lung cancer…

This early-stage study is testing a new drug called RMC-5127, both by itself and combined with other cancer drugs, in adults with advanced solid tumors that have a specific genetic change called KRAS G12V. The main goals are to find safe doses and see how the body processes the d…

This study is testing whether adding the drug fruquintinib to standard chemotherapy (FOLFIRI) can better control advanced colorectal cancer that has spread. The trial is for people whose cancer has continued to grow despite initial treatment. Researchers will measure how long the…

This early-stage trial is testing a new drug called tegavivint for people with advanced colorectal cancer that has spread. The main goals are to find a safe dose and see if the drug, given alone or with standard treatments, can help shrink tumors. The study is for adults whose ca…

This study is testing if adding two drugs (an immunotherapy called a PD-1 antibody and a drug called bevacizumab) to standard chemotherapy before surgery works better than chemotherapy alone for people with a specific type of locally advanced colon or rectal cancer. The goal is t…

This study is testing an experimental oral medication called JYP0015 in adults with advanced cancers that have specific RAS mutations, including pancreatic, lung, and colorectal cancers. The trial aims to find a safe dose and see if the drug can shrink tumors in patients who have…

This study is testing new combinations of experimental drugs for people with advanced solid tumors that have specific RAS mutations. Researchers want to see if combining a new type of drug called a RAS(ON) inhibitor with another cancer drug called ivonescimab is safe and can help…

This is the first study in people to test a new drug called CBI-1214, which is designed to help the body's own immune cells attack cancer. It is for adults with advanced or metastatic colorectal cancer that has continued to grow despite prior standard treatments. The main goals a…

This is a first-in-human study to test the safety and find the right dose of a new oral drug, OKN4395, for people with advanced solid tumors. The trial will give the drug alone and combined with an existing immunotherapy (pembrolizumab) to about 166 participants with cancers like…

This early-stage study is testing a new drug called BMS-986523, both alone and combined with other cancer treatments, in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to check if the drug is safe, how the body processes it,…

This study is testing a two-part approach for people with advanced cancers that cannot be removed by surgery. First, a special imaging scan is used to see if a tumor has a specific target. If it does, a targeted radiation treatment is given to try to control the cancer. The main …

This study is testing an experimental drug called HLX43 in people with advanced colorectal cancer that has continued to grow despite standard treatments. About 60 participants will receive the drug at different doses to find the best balance of effectiveness and safety. The main …

This is the first-ever study in humans of a new experimental drug called TH9619 for people with advanced solid tumors. The trial aims to find a safe and effective dose while checking how the body processes the drug and whether it shows signs of fighting cancer. It's open to adult…

This study is testing a new oral drug, ABT-301, combined with two existing cancer immunotherapies (tislelizumab and bevacizumab) for people with a specific type of advanced colorectal cancer that has spread. The main goals are to find the safest dose of the new drug and see if th…

This study is testing a new drug called XL092, both by itself and in combination with other immunotherapy drugs, for people with advanced solid tumors that cannot be removed by surgery. The main goals are to find safe doses and see if the treatments can shrink tumors or slow thei…

This early-stage study is testing the safety and initial effectiveness of a new type of personalized immune cell therapy called CDH17/GUCY2C CAR-T in patients with advanced colorectal cancer. The therapy involves modifying a patient's own immune cells to target and fight their ca…

This study aims to see how common colon cancer or pre-cancerous growths are in adults who were recently hospitalized with a serious blood infection caused by gut bacteria. Researchers will offer participants a swallowable camera capsule that takes pictures as it travels through t…

This study is testing a new blood test designed to detect colorectal cancer early. Researchers will enroll 3,200 average-risk adults aged 45-75 who are scheduled for a routine colonoscopy. They will compare the results of the blood test to the colonoscopy findings to see how accu…

This study is testing whether a simple at-home stool test (FIT) is accurate enough to detect if bowel cancer has returned in people who have had surgery for it. The goal is to see if this easy test could one day help some patients avoid the need for a follow-up colonoscopy, which…

This study aims to see if proteins in urine can predict how well patients with locally advanced colorectal cancer will respond to pre-surgery (neoadjuvant) therapy. Researchers will collect urine samples from 400 patients before and after treatment, using advanced protein analysi…

This study is collecting blood samples to develop and test a new blood test for detecting colorectal cancer and advanced precancerous growths. It will enroll 1300 US adults aged 45-84, including people scheduled for colon cancer surgery and people getting routine colonoscopies. T…

This study is testing whether a digital support tool can help people with breast, prostate, or colorectal cancer sit less during their treatment. The goal is to see if reducing long periods of sitting improves their well-being, reduces side effects, and lowers future health risks…

This study aims to understand how different types of anesthesia affect muscle loss in patients undergoing colorectal cancer surgery. Researchers will compare two common anesthesia methods to see if one better preserves muscle mass and strength. The study will observe 40 adult pat…