Vasculitis

This early-phase trial is testing a new cell therapy called GT719 for several immune-mediated kidney diseases, including IgA nephropathy and membranous nephropathy. The therapy uses specially engineered immune cells to target and potentially control the disease. The study will en…

This study tests whether adding a drug called firsekibart to the standard treatment (IVIG and aspirin) can better prevent coronary artery damage in children with Kawasaki disease. Kawasaki disease causes inflammation in blood vessels, especially those supplying the heart, and can…

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This early-stage trial tests a one-time infusion of donor immune cells (CAR-γδT cells) designed to target and destroy faulty B cells in people with severe autoimmune diseases like lupus and scleroderma. The main goal is to check safety and find the right dose in 9 adults whose di…

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This phase II trial tests whether adding bosentan to standard steroid treatment helps people with giant cell arteritis (GCA) avoid relapses and reduce steroid use. About 40 adults with GCA will receive either bosentan plus steroids or steroids alone for 3 months, then be followed…

This study tests whether people with giant cell arteritis (GCA) can safely take steroids for only 8 weeks instead of the usual 26 weeks when also using the drug tocilizumab. About 178 participants will be randomly assigned to one of two treatment lengths. The goal is to see if th…

This phase 2 trial tests whether secukinumab, a drug that blocks IL-17A, can help people with active severe Takayasu arteritis achieve remission and stop taking steroids. About 52 participants will receive either secukinumab injections or standard care (like TNF inhibitors). The …

This study tests two new drugs, vunakizumab and ivarmacitinib, for people with active Takayasu arteritis (TAK), a rare disease that causes inflammation in large blood vessels. The trial will enroll 180 adults aged 18-70 whose disease is still active despite standard treatments. R…

This study looks at whether giving the drug rituximab early, when signs of the disease reappear in the blood, can prevent relapses in people with certain types of vasculitis (GPA and MPA). About 70 adults who have been on maintenance rituximab for at least 18 months will be rando…

This early-stage trial will test a new cell therapy called YTS109 in 12 children aged 5 to 17 with severe autoimmune diseases like lupus or scleroderma that have not responded to standard treatments. The children will receive a single infusion of these cells, and researchers will…

This Phase 3 trial tests whether adding avacopan to standard treatment helps people with severe ANCA vasculitis and serious kidney damage. About 130 participants will receive either avacopan or a placebo alongside usual care. The goal is to see if more patients recover kidney fun…

This study tests whether using a catheter to deliver clot-busting drugs or a device to physically remove the clot can help people with acute deep vein thrombosis (DVT) who do not improve after one week of blood thinners. About 100 adults aged 18 to 75 with acute DVT in the leg wi…

This early study tests a new drug called STR-P004 in 9 adults with immune-mediated kidney diseases. The goal is to see if the drug is safe and how the body processes it. Participants receive up to 8 infusions over 28 days, with possible dose increases. This is not a cure; it aims…

This study looks at whether the drug telitacicept works better than standard steroids for children aged 3-17 with kidney inflammation caused by IgA vasculitis. About 300 participants will be followed for up to 48 weeks to see if their urine protein levels drop and kidney function…

This study tests whether adding pirfenidone, a drug used for lung and liver scarring, to standard treatment can improve blood vessel damage in people with Takayasu arteritis. About 92 adults aged 18-60 will receive either pirfenidone or a placebo for 6 months. The goal is to see …

This early-phase trial will test BCT301, a type of immune cell made from stem cells, in 10 people with severe autoimmune diseases like lupus and scleroderma. Participants receive a single infusion of these cells after a short course of chemotherapy. The main goal is to check safe…

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This study tests a new treatment using CD19 CAR T-cells for people with severe autoimmune diseases that haven't improved with standard therapies. About 30 participants will receive a single dose of these engineered immune cells after chemotherapy. The goal is to see if it's safe …

This study will test a new type of PET/CT scanner, called Long-Axial Field-of-View (LAFOV), to see if it can provide clearer images of blood vessel inflammation in people with large vessel vasculitis (LVV). The scanner is more sensitive and can image the whole body faster, potent…

This study looks at how quickly the optic nerve sheath shrinks after starting steroids in people with giant cell arteritis, a condition that can cause blindness. Researchers will use eye ultrasounds and blood tests over two months in 60 newly diagnosed patients. The goal is to fi…

This study looks at whether a detailed MRI of the blood vessel wall can help doctors tell the difference between two common causes of stroke: hardening of the arteries (plaque buildup) and inflammation of the vessel wall (vasculitis). About 46 people who recently had a stroke wil…

This study will test whether an artificial intelligence system can spot signs of Kawasaki disease in children's chest X-rays earlier than standard methods. Researchers will analyze data from 20,000 children to see if the AI can predict the best time for treatment and reduce heart…

This study compares three topical treatments—sesame oil, aloe vera gel, and nitroglycerin ointment—against no treatment for preventing phlebitis (vein inflammation) caused by chemotherapy. Researchers will enroll 190 adults with breast or colon cancer receiving specific chemo dru…

This study explores whether a self-guided web program called 'Better Nights, Better Days for Youth' can improve sleep and reduce pain in teenagers with rheumatic diseases like arthritis and lupus. Teens aged 12-18 with sleep problems will track their sleep and pain daily, then us…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This pilot study is investigating how quickly C-reactive protein (CRP), a key marker of inflammation, drops after starting steroid treatment in people newly diagnosed with giant cell arteritis. By measuring CRP levels daily, then weekly and monthly for up to a year, researchers h…

Superficial vein thrombosis (SVT) is a painful but usually harmless blood clot just under the skin. However, about 4% of people develop more serious clots in deep veins or lungs. Current guidelines recommend ultrasound scans to decide if blood thinners are needed, but scans are o…

This study follows 120 adults with ANCA-associated vasculitis, an autoimmune disease, who are receiving rituximab therapy. Researchers will collect blood samples over time to look for immune cell changes that signal a coming relapse. The goal is to find biomarkers that help docto…

This observational study will test a behavioral program designed to improve how nurses and anesthesiologists handle IV catheters. Over three years, one hospital will use the program while another continues usual care. Researchers will track complications like phlebitis and infilt…

This study will use a special scan to look for B cells (a type of immune cell) in the blood vessels of 30 people with giant cell arteritis, a serious disease that can cause blindness or stroke. Current treatments rely on steroids, which have harsh side effects. If the scan works,…

This study will test whether a special ultrasound score, called OTUS, can accurately track disease activity in people with Takayasu arteritis, a rare condition that causes inflammation of the large arteries. Researchers will follow 100 patients with active disease, performing ult…

This study compares two modern teaching methods—simulation with actors and video-based learning—against traditional lectures to see which best helps nursing students recognize phlebitis (a painful vein inflammation from IVs) and make better clinical decisions. About 90 first-year…

This study looks at whether two substances in the blood, IL-6 and MMP-7, can help doctors diagnose and predict the course of a rare lung disease in children. Researchers will measure these markers in 60 children with immune-mediated interstitial lung disease and compare them to h…

This study will observe 150 children with Kawasaki disease to learn more about a rare but serious complication called Macrophage Activation Syndrome (MAS). Researchers will collect data on symptoms, lab results, and treatments across multiple European hospitals. The goal is to be…

This study will follow 1,500 people with lupus or other autoimmune diseases to see if advanced heart scans can predict heart attacks, strokes, or other heart problems. Participants will have one of three types of heart imaging. The goal is to learn if these scans can help doctors…

This study aims to see if there is a connection between two types of inflammatory conditions: one affecting the spine and joints (spondylarthritis) and another affecting blood vessels (giant cell arteritis) or muscles (polymyalgia rheumatica). Researchers will compare 10 adults w…

This study observes 80 adults with giant cell arteritis (GCA) affecting large arteries who are taking upadacitinib as part of their routine care. Researchers will collect data from medical records to see how many achieve remission at 24 weeks and track relapses over 2 years. No e…

This study tests a new infusion monitoring system designed to help nurses catch complications like phlebitis, infiltration, and extravasation early in ICU patients. Researchers will compare complication rates before and after using the system in 102 patients. The goal is to see i…