Somatoform disorder

This study looked at liver cancer patients whose tumors shrank completely after non-surgical treatments like chemoembolization and immunotherapy. Researchers compared those who then had surgery to remove any remaining tissue versus those who simply watched and waited. The goal wa…

This study compares a smartphone app (iPhone Level) to a specialized device (BROM) for measuring how much the lower back can bend forward, backward, and sideways. Researchers will enroll 120 healthy male university students aged 18–25 with normal body weight. If the app works wel…

This study tested a new questionnaire called SSS-CN to see if it can accurately detect somatic symptom disorder (physical discomfort with no clear medical cause) in heart clinic patients. Over 1,800 adults aged 18-80 who had no diagnosed physical illness completed the checklist a…

This study tests an online cognitive therapy program, guided by a therapist, to help colorectal cancer survivors who have finished treatment reduce their fear of the cancer returning. The program includes educational text, exercises, and videos. Researchers will compare it to sta…

This trial tests whether a wearable suit called EXOPULSE Mollii, which sends gentle electrical pulses to muscles, can help children with cerebral palsy. The study focuses on kids aged 5 to 12 who have spasticity and some walking ability. Researchers will measure changes in balanc…

This trial compares two versions of an internet-based emotional awareness and expression therapy (I-EAET) for people with functional somatic disorder—a condition where physical symptoms like chronic pain or fatigue have no clear medical cause. One group gets weekly written feedba…

This trial compares two types of first interviews for people with functional somatic disorders — conditions like irritable bowel syndrome or fibromyalgia where physical symptoms have no clear medical cause. One interview focuses on life stress and emotional factors, while the oth…

This trial tests whether a short-term, intensive talk therapy called ISTDP can help people whose physical symptoms—like chronic pain, fatigue, or stomach issues—have not improved with other treatments. The therapy focuses on uncovering and processing unconscious emotions that may…

This study tests a smartphone app called STAMP+CBT that combines pain coping skills training with medication support for people with advanced cancer who have chronic pain. The app provides tailored education and real-time feedback to help users manage their pain. Researchers want…

This study tests a new group therapy called MIND-over-MIRROR for adults with body dysmorphic disorder (BDD), a condition where people become excessively preoccupied with perceived flaws in their appearance. The therapy combines acceptance and commitment techniques with compassion…

This study tests whether a specific type of talk therapy called cognitive behavioral therapy (CBT) can help people with body dysmorphic disorder (BDD). Participants receive 22 weekly one-on-one CBT sessions that teach them to challenge negative thoughts and behaviors about their …

This study tested whether an internet-based exposure therapy program can reduce distress related to physical symptoms better than standard education about healthy lifestyle habits. 161 adults in Stockholm with significant distress from somatic symptoms participated. The treatment…

This study tested whether task-specific electrical stimulation can improve upper limb motor skills in 30 children aged 4 to 7 with spastic quadriplegia cerebral palsy. The therapy uses mild electrical pulses to activate muscles during functional tasks. The goal was to see if this…

This study tested whether a mobile app could help adults with somatic symptom disorder or medically unexplained symptoms. 46 participants used the app for 8 weeks, which taught coping skills like mindfulness and stress management. The goal was to see if symptoms improved compared…

This study tested a resilience coaching program (PRISM) for 260 teens aged 12-17 with chronic musculoskeletal pain. The goal was to see if coaching improves daily function, reduces distress, and lessens pain compared to usual care. Participants completed surveys and coaching sess…

This study tested new non-drug treatments to reduce nerve pain in the feet and legs of people with HIV. 161 adults with HIV-related nerve pain tried these approaches to see if they could ease pain and improve quality of life. The goal was to find better ways to manage this common…

This study tested whether a non-invasive brain stimulation technique called rTMS could help people with psychogenic paralysis (paralysis with no physical cause). 66 participants received two sessions of either real or sham rTMS over two days. The main goal was to see if paralysis…

This study tested two laser treatments—low-level and high-intensity—in 40 people with frozen shoulder (adhesive capsulitis). The goal was to see which better reduces pain, improves shoulder movement, and boosts daily function over three weeks. Both treatments are non-invasive and…

This study looked at whether 12 weeks of Cognitive-Behavioral Therapy (CBT) can help people with Body Dysmorphic Disorder (BDD), a condition where someone is overly worried about small or imagined flaws in how they look. Sixty adults took part; half received weekly CBT sessions, …

This study tested whether progressive muscle relaxation (PMR) — a technique where you tense and then relax different muscle groups — could help nursing students feel less depressed, anxious, and stressed. Over 100 students were split into two groups; one group practiced PMR three…

This pilot study tested whether transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, can improve motor symptoms in people with functional neurological disorder (FND). Fifty-one adults with limb weakness received TMS over the motor cortex. The study…

This study tested a short, four-session therapy program for people who worry excessively about their health. Medical assistants delivered the therapy in primary care clinics. 68 adults took part, and the study measured changes in health anxiety over 12 weeks. The goal was to see …

This pilot study tested whether prolonged exposure teletherapy can help adults with psychogenic nonepileptic seizures (PNES) and PTSD. Forty-four participants received either the teletherapy or standard education about PNES. The goal was to see if the therapy reduces seizure freq…

This study tested a 4-week app-based cognitive behavioral therapy (CBT) program in 20 people with functional tremor. Participants used the app to practice reframing upsetting thoughts and were compared to a group that simply reflected on their day. The goal was to see if the CBT …

This study tested whether a therapy called EMDR (eye movement desensitisation and reprocessing) could help people with functional neurological disorder (FND), a condition where the brain doesn't send signals properly, causing symptoms like seizures, shaking, or weakness. Fifty ad…

This study tested a group version of a therapy program called the Unified Protocol for teens with emotional disorders like anxiety and depression. Thirty-one adolescents took part in 16 weekly group sessions at a public mental health center in Spain, along with three parent sessi…

This study tested whether text message reminders to stop 'safety behaviors' (like checking mirrors or seeking reassurance) could ease appearance concerns. 401 adults with body dysmorphic disorder, social anxiety, or eating disorders were split into two groups: one received text p…

This study looks at 20 adults who were admitted to a stroke unit with stroke-like symptoms but were found not to have a stroke or other neurological disease. The goal is to describe their thinking and behavior patterns and track their symptoms over 6 months. This research aims to…

This study looks at how a single dose of psilocybin, the active ingredient in magic mushrooms, affects brain networks in 24 adults with functional neurological disorder (FND). Participants receive the drug with therapeutic support, and brain scans are taken before and after to se…

This observational study compares functional movement, dynamic balance, and lower body strength between 144 professional and amateur male soccer players. Participants undergo standardized tests like the Functional Movement Screen, Y-Balance Test, and jump and strength assessments…

This study looked at how pregnant women's online health information seeking (cyberchondria) relates to their anxiety levels and how they perceive their own health. 166 pregnant women completed questionnaires about their internet health habits, anxiety, and health perception. The …

This study looked at whether digital services like smartphone apps can help people with psychosomatic disorders continue their treatment during the COVID-19 pandemic, when social distancing and hygiene rules limit in-person therapy. About 2000 patients from clinics took part, usi…

This study tested a program for people with long-COVID that includes an online screening, a detailed in-person assessment, and digital training modules with a personal counselor. 192 participants from Bavaria took part to see if this approach is practical and helpful. The goal wa…

This completed study looked at video-EEG recordings from 50 adults with psychogenic nonepileptic seizures (PNES). Researchers aimed to identify distinct patterns in how these seizures look and behave. They classified events into three clusters based on features like movement and …

This completed study looked back at the records of 50 adults diagnosed with psychogenic nonepileptic seizures (PNES) who had video-EEG monitoring. Researchers reviewed the video and brain wave data to describe the different types of seizure movements and other features. The goal …

This completed study looked at how a noninvasive brain stimulation technique called TMS affects the way people with body dysmorphic disorder (BDD) process visual information. Forty adults with BDD or mild symptoms received either intermittent or continuous TMS over the parietal b…

This study looked at how certain personality traits, physical symptoms without clear cause, and social support relate to temporomandibular joint (TMJ) disorders, which cause jaw pain and difficulty chewing. Researchers compared 90 adults with TMJ disorders to healthy volunteers u…

This study tested whether real-time fMRI neurofeedback can help people with anxiety disorders better regulate their emotions. 21 participants practiced cognitive reappraisal while receiving feedback on their prefrontal cortex activity. The goal was to understand the brain mechani…

This study looked at 20 people with a first episode of motor conversion disorder, a condition where psychological stress causes physical symptoms like paralysis. Researchers used PET scans to measure brain metabolism at the start of symptoms and checked if those patterns related …

This study examined 20 adults experiencing their first episode of conversion disorder (a condition where psychological stress causes physical symptoms like paralysis or abnormal movements). Researchers measured inflammation markers in the blood and compared them with brain scans …

This study looked at over 9,000 people in China to compare how often older and younger adults experience physical symptoms without a clear medical cause, like pain or fatigue. Researchers used questionnaires to measure these symptoms, along with depression and anxiety. The goal w…