Somatoform disorder

Functional somatic disorders cause persistent physical symptoms that doctors cannot explain by other diseases. The DISTRESS trial evaluates a new clinic where internal medicine doctors, trained to recognize these disorders, examine patients and provide guidance to their general p…

This trial tests whether a sudden, loud hand clap can help doctors quickly tell apart epileptic seizures from psychogenic non-epileptic seizures (PNES), which look similar but have different causes. About 400 people undergoing video-EEG monitoring will receive the clap test durin…

This study tests whether a 24-week collaborative care program can improve quality of life for adults with epilepsy who also have anxiety or depression. The program includes regular check-in calls and expert recommendations from a psychiatrist and neurologist. Researchers will com…

This study tests whether adding a nerve stimulator to standard ultrasound guidance improves the quality of nerve blocks for upper limb surgery. 82 adults having elective arm surgery will be randomly assigned to receive the block with or without the stimulator active. Researchers …

This trial tests whether transcranial electrical stimulation (tES) — a safe, non-invasive technique that sends a mild electrical current through the scalp — can reduce pain and improve quality of life in children and adolescents aged 10 to 21 with juvenile fibromyalgia or other n…

This trial tests whether heart rate variability biofeedback—a non-invasive technique that teaches people to control their heart rhythm—can ease symptoms of functional neurological disorders (FND), a condition where the brain and nervous system don't function properly despite no s…

This trial tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve symptoms of functional movement disorder (FMD), a condition causing involuntary movements without a known neurological cause. Adults aged 18 to 80 with a…

This pilot study tests whether a form of psychotherapy called Emotional Awareness and Expression Therapy (EAET), delivered via telehealth in a group setting, can reduce the severity of persistent physical symptoms like pain or fatigue. Participants are adults who have undergone a…

This study tests whether an 8-week online mindfulness program (MBSR) can improve emotional intelligence and reduce stress-related physical symptoms in adolescents aged 14 to 18 who have experienced bullying and childhood trauma. About 44 teens are randomly assigned to either the …

This study tests whether a structured dance and movement program is practical and acceptable for people with functional neurological disorder (FND), a condition where the brain doesn't send proper signals to the body. Thirty adults with FND will be randomly assigned to either dan…

This study tests whether a short, intensive course of cognitive behavioral therapy (CBT) over 2 weeks works better than the usual weekly sessions over 6 months for people with anxiety disorders. 120 adults with conditions like panic disorder, OCD, or PTSD will be randomly assigne…

This study tests a smartphone app called Tremor Retrainer for people with functional tremor, a movement disorder not caused by other diseases. About 20 participants aged 10 and older will use the app and be monitored via video. The goal is to see if the app is easy to use and if …

This study looks at whether unlicensed professionals can successfully provide cognitive behavioral therapy (CBT) to patients in a general hospital. It includes 250 adults with conditions like anxiety, depression, OCD, and PTSD. The goal is to see if this approach improves psychol…

This study tests whether virtual reality sessions with a psychologist can improve body image dissatisfaction in people who had bariatric surgery 18 to 30 months ago. Eleven participants will either receive 10 weekly VR sessions or standard follow-up care. The main goal is to see …

This study tests a 12-week nurse-led digital education program for young men (ages 18-30) who have bigorexia, also known as muscle dysmorphia. Participants must attend a gym and score high on a bigorexia scale. The program aims to improve body image, reduce social anxiety about a…

This study was designed to see if a biofeedback device called JOGO could help people with functional tremor, a condition where the body shakes uncontrollably. JOGO uses stickers on the skin to read muscle activity and then guides users through training sessions to reduce shaking.…

This study looks at adults with chronic pain who receive ketamine infusions at Stanford's Pain Management Center. Researchers want to understand which patients improve and what factors predict a good response. The goal is to better tailor this treatment to individuals.

This study compares two non-invasive devices that stimulate the vagus nerve—one placed on the neck, the other on the ear—to see which better reduces physical discomfort and health-related anxiety in people with somatic symptom disorder. Sixty participants will try both devices in…

This study is testing whether Jing Si Herbal Tea can reduce pain and anxiety in people donating peripheral blood stem cells. 80 healthy donors aged 20-55 will drink the tea and report their symptoms. The goal is to see if this simple drink can improve the donation experience.

This study investigates the link between autism and physical symptoms like gastrointestinal issues, autoimmune diseases, and heart problems. Researchers will compare autistic individuals, people with anxiety or depression, and healthy controls to understand how these symptoms are…

This study looks at 50 adults with sleep bruxism (teeth grinding during sleep) to understand how it affects sleep, pain, anxiety, and overall health. Researchers will use sleep tests, blood samples, and questionnaires to find links between bruxism and other conditions. The goal i…

This study is testing a new way to care for people with rare diseases. It will use advanced genetic testing and a team of specialists to help diagnose patients faster and coordinate their care better. The study involves 136 participants with certain rare diseases and aims to redu…

This observational study is collecting data from 2,617 young people (ages 12-30) at clinical high risk for psychosis, plus healthy controls, across 13 countries. Researchers will use clinical assessments, cognitive tests, and biomarkers to build algorithms that predict who will r…