Can magnetic pulses rewire the brain to ease movement symptoms?
NCT ID NCT05155059
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve symptoms of functional movement disorder (FMD), a condition causing involuntary movements without a known neurological cause. Adults aged 18 to 80 with a neurologist-confirmed FMD diagnosis will be randomly assigned to receive either real TMS or a sham (placebo) treatment over five daily sessions. Researchers will compare symptom changes at one, two, and six months after treatment to see if the stimulation offers lasting relief.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Repetitive transcranial magnetic stimulation (TMS) using intermittent theta burst stimulation
- What this could lead to
- If effective, this could offer a non-invasive, drug-free treatment option to reduce disabling symptoms of functional movement disorder.
- What could go wrong
- This is a small early-phase trial, so results may not apply broadly. The sham comparison helps, but benefits could be modest or temporary, and TMS may cause mild side effects like headache or scalp discomfort.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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25 people
The number who actually took part.
- Started
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May 2022
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or female, aged 18-80 * Diagnosis of functional movement disorder made by a neurologist * Agreement to adhere to Lifestyle Considerations throughout study duration * Ability of subject to understand and the willingness to sign a written informed consent document. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: * Current psychosis or active suicidal ideation * History of epilepsy with the exception of febrile seizure * Patients with psychogenic non-epileptic seizure without comcomitant functional movement disorder * Any significant neurological disorders other than FMD including but not limited to multiple sclerosis, stroke, Parkinson s disease, space occupying brain lesion * Alcohol or substance use disorder * Patients who are on Buproprion (Wellbutrin) * Patients with moderate to severe cardiac disease * Any psychiatric, medical or social condition due to which, in the judgment of the PI and after any consults if indicated, participation in the study is not in the best interest of the patient. * Pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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