Talking through the pain: could uncovering hidden emotions relieve chronic symptoms?
NCT ID NCT06682104
First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time
Summary
This trial tests whether a short-term, intensive talk therapy called ISTDP can help people whose physical symptoms—like chronic pain, fatigue, or stomach issues—have not improved with other treatments. The therapy focuses on uncovering and processing unconscious emotions that may be fueling the symptoms. Twenty-five adults who have already had a medical evaluation and still experience significant distress will participate.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- intensive short-term psychodynamic psychotherapy (ISTDP)
- What this could lead to
- If it works, this could offer a new option for people with chronic physical symptoms that have not responded to standard medical or psychological care.
- What could go wrong
- This is a very small early trial with only 25 participants, so results may not apply widely. The therapy is intensive and may not be suitable for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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25 people
The number who actually took part.
- Started
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Feb 2025
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * The participant certifies that they have undergone a medical evaluation for their physical symptoms. * The participant rates either moderate distress from physical symptoms on the PHQ-15 form (over 10 points) or significant distress from a single physical symptom (at least 2 points for that symptom). * The participant expresses interest in exploring whether emotional factors, such as stress, may contribute to their symptom profile. * Any prescribed medications must have been stable for at least 1 month. * Participants must meet the criteria for non-response/treatment resistance, i.e., no reliable change in PHQ-15. Exclusion Criteria: * Participants suffer from ongoing substance abuse (alcohol or drugs) or are assessed to have severe mental health issues (psychotic disorders, moderate to high suicide risk, antisocial personality disorder, etc.). * Participants are currently prescribed medications that are clearly addictive and sedative in nature (e.g., benzodiazepines). * Participants are involved in other psychological treatments focused on physical symptoms. However, other psychological treatments are allowed as long as the supportive therapy does not occur more than once a month. * Participants do not have sufficient proficiency in the Swedish language. * Somatic symptoms is judged to be need further medically evaluation or treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Stockholm University
Stockholm, 10691, Sweden
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