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Brain scans may predict recovery in conversion disorder

NCT ID NCT02329626

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nīmes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 20 people with a first episode of motor conversion disorder, a condition where psychological stress causes physical symptoms like paralysis. Researchers used PET scans to measure brain metabolism at the start of symptoms and checked if those patterns related to recovery after 6 months. The goal was to see if brain imaging could help predict outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors predict recovery in motor conversion disorder using brain scans.
What could go wrong
This is a very small, early observational study with only 20 people. It is not testing a treatment, so it may not lead to any direct benefit for patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

20 people

The number who actually took part.

Started

Jan 2016

Finished

Jan 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of patients with paralysis, motor weakness or abnormal movements meeting DSM-IV criteria for motor conversion disorder consulting via the Emergency or Neurology department of participating centers.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The patient must have given free and informed consent and signed the consent * The patient must be affiliated with or beneficiary of a health insurance plan * The patient meets DSM-IV criteria for motor conversion disorder (with paralysis, motor weakness or abnormal movements) lasting for less than 1 month and euthymic (HAMD score \< or = 7, as evaluated by a psychiatrist) * First episode (incident cases) * The latest symptom dates to within a month * The patient is not under neuroleptics Exclusion Criteria: * The subject is participating in another study * The subject is in an exclusion period determined by a previous study * The subject is under judicial protection, guardianship or curatorship * The subject refuses to sign the consent * It is not possible to correctly inform the patient * The patient is pregnant, parturient or she is breastfeeding * Specialized clinical neurological examination and brain and spinal cord MRI revealed an organic neurological cause * The subject has a HAMD score \> 7 * The subject currently has manic/hypomanic episode, a diagnosis of substance abuse or dependency (excluding tobacco), a diagnosis of schizophrenia (any time in the past) or chronic neurological disease (active epilepsy, stroke, brain tumor) * Suicidal or high risk for suicide (according to MINI assessment) * Contra-indication for a PET scan * Patient under neuroleptics at inclusion * The last symptom happened over 1 month ago * The patient has had previous episodes (prevalent cases)

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Conditions

The condition(s) this trial relates to.

conversion disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Conversion disorder

Contacts and locations

Locations

  • CHRU de Montpellier - Hôpital Gui de Chauliac

    Montpellier, 34295, France

  • CHRU de Montpellier - Hôpital Lapeyronie

    Montpellier, 34295, France

  • CHRU de Nîmes - Hôpital Universitaire Carémeau

    Nîmes, 30029, France

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