Scientists hunt for biological clues in mysterious movement disorder
NCT ID NCT05305014
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study examined 20 adults experiencing their first episode of conversion disorder (a condition where psychological stress causes physical symptoms like paralysis or abnormal movements). Researchers measured inflammation markers in the blood and compared them with brain scans to find biological clues that could help diagnose and treat this poorly understood condition. The goal is to improve understanding, not to test a treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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20 people
The number who actually took part.
- Started
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Apr 2022
- Finished
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Apr 2022
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
20 patients with paralysis, motor weakness or abnormal movements corresponding to the DSM-IV criteria of conversive motor disorder consulting the SAU or the Neurology departments of the CHU of Nîmes and Montpellier already included in the HYCORE mother study.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * The patient must have given free and informed consent and signed the consent. * Patient must be enrolled in or a beneficiary of a health insurance plan. * Patient's age is \> 18 and ≤ 65 years. * Patient meets DSM-IV criteria for conversive motor disorder (with paralysis, motor weakness, or abnormal movements) evolving for less than 1 month and is euthymic (HAMD score \< or =7 assessed by a psychiatrist). * First episode (incident case) * The last symptom is less than one month old. * The patient is not on neuroleptics. Exclusion Criteria: * Subject is participating in another study * Subject is in an exclusion period determined by a previous study * Subject is under court protection, guardianship, or conservatorship * The subject refuses to sign the consent form * It is impossible to provide the subject with informed information * The patient is pregnant, parturient, or nursing * Specialized neurological clinical examination and brain and spinal cord MRI reveal organic neurological damage * The subject presents a HAMD score \>7 * Subject has a current manic or hypomanic episode, a current diagnosis of substance abuse/dependence (excluding tobacco), a lifetime diagnosis of schizophrenia, or a chronic neurological condition (active epilepsy, stroke, brain tumor) * Suicidal or high-risk subjects (assessed using the MINI) * The subject has a contraindication to the performance of a PET scan * Patient is on neuroleptic medication at inclusion * The last symptom is more than one month old * The patient has already had an episode (prevalent case).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ismael CONEJERO
Nîmes, Choisir Une Région, 30029, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.