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Brain zaps reveal how BDD patients see faces differently

NCT ID NCT05607121

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at how a noninvasive brain stimulation technique called TMS affects the way people with body dysmorphic disorder (BDD) process visual information. Forty adults with BDD or mild symptoms received either intermittent or continuous TMS over the parietal brain region, then had their brain activity scanned while viewing faces. The goal was to understand changes in brain connections and visual perception, not to treat the disorder.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial magnetic stimulation (TMS)
What this could lead to
If successful, this study could reveal how brain stimulation changes visual perception in body dysmorphic disorder, pointing toward new ways to understand or treat the condition.
What could go wrong
This is a small, early-stage observational study with only 40 participants. It is not designed to test a treatment, so any insights are preliminary and may not lead to direct therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jun 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Body dysmorphic disorder: Inclusion: * males or females * ages 18-40 * meet Diagnostic and Statistical Manual (DSM-5) criteria for Body Dysmorphic Disorder * have a Body Dysmorphic Disorder version of the Yale-Brown Obsessive-Compulsive Disorder Scale (BDD-YBOCS) score of ≥20 * primary appearance concerns of the face or head area * medication naïve or medication free for at least 8 weeks prior to enrollment Subclinical body dysmorphic disorder: * males or females * ages 18-40 * have a score on the Dysmorphic Concern Questionnaire of ≥8 (1 standard deviation \[STD\] above population norms) * primary appearance concerns of the face or head area * medication naïve or medication free for at least 8 weeks prior to enrollment Exclusion Criteria: Body dysmorphic disorder: * concurrent major Axis I disorders including substance use disorders, aside from anxiety disorders or depressive disorders as these comorbidities are very common and the sample would otherwise be non-representative; however, BDD must be the primary diagnosis. * lifetime: bipolar disorder or psychotic disorder * psychotropic medications, aside from a short half-life sedative/hypnotic for insomnia, or a short half-life benzodiazepine as needed for anxiety but not exceeding a frequency of 3 doses in one week and not to be taken on the days of the training or MRI scan * current cognitive-behavioral therapy Subclinical body dysmorphic disorder: Exclusion: * meet full DSM-5 criteria for body dysmorphic disorder * current Axis I disorders including substance use disorders * lifetime: bipolar disorder or psychotic disorder * psychotropic medications, aside from a short half-life sedative/hypnotic for insomnia, or a short half-life benzodiazepine as needed for anxiety but not exceeding a frequency of 3 doses in one week and not to be taken on the days of the training or MRI scan * current cognitive-behavioral therapy Exclusion criteria for all participants: * Neurological disorder * Pregnancy * Current major medical disorders that may affect cerebral metabolism such as diabetes or thyroid disorders * Current risk of suicide with a plan and intent * Ferromagnetic metal implantations or devices (electronic implants or devices, infusion pumps, aneurysm clips, metal fragments or foreign bodies, metal prostheses, joints, rods or plates) * Visual acuity worse than 20/35 for each eye as determined by Snellen close vision acuity chart (vision will be tested with corrective lenses if participant uses them).

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Centre for Addiction and Mental Health

    Toronto, Ontario, M6J 1H3, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.