Brain zaps reveal how BDD patients see faces differently
NCT ID NCT05607121
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at how a noninvasive brain stimulation technique called TMS affects the way people with body dysmorphic disorder (BDD) process visual information. Forty adults with BDD or mild symptoms received either intermittent or continuous TMS over the parietal brain region, then had their brain activity scanned while viewing faces. The goal was to understand changes in brain connections and visual perception, not to treat the disorder.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcranial magnetic stimulation (TMS)
- What this could lead to
- If successful, this study could reveal how brain stimulation changes visual perception in body dysmorphic disorder, pointing toward new ways to understand or treat the condition.
- What could go wrong
- This is a small, early-stage observational study with only 40 participants. It is not designed to test a treatment, so any insights are preliminary and may not lead to direct therapies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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40 people
The number who actually took part.
- Started
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Jun 2023
- Finished
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Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Body dysmorphic disorder: Inclusion: * males or females * ages 18-40 * meet Diagnostic and Statistical Manual (DSM-5) criteria for Body Dysmorphic Disorder * have a Body Dysmorphic Disorder version of the Yale-Brown Obsessive-Compulsive Disorder Scale (BDD-YBOCS) score of ≥20 * primary appearance concerns of the face or head area * medication naïve or medication free for at least 8 weeks prior to enrollment Subclinical body dysmorphic disorder: * males or females * ages 18-40 * have a score on the Dysmorphic Concern Questionnaire of ≥8 (1 standard deviation \[STD\] above population norms) * primary appearance concerns of the face or head area * medication naïve or medication free for at least 8 weeks prior to enrollment Exclusion Criteria: Body dysmorphic disorder: * concurrent major Axis I disorders including substance use disorders, aside from anxiety disorders or depressive disorders as these comorbidities are very common and the sample would otherwise be non-representative; however, BDD must be the primary diagnosis. * lifetime: bipolar disorder or psychotic disorder * psychotropic medications, aside from a short half-life sedative/hypnotic for insomnia, or a short half-life benzodiazepine as needed for anxiety but not exceeding a frequency of 3 doses in one week and not to be taken on the days of the training or MRI scan * current cognitive-behavioral therapy Subclinical body dysmorphic disorder: Exclusion: * meet full DSM-5 criteria for body dysmorphic disorder * current Axis I disorders including substance use disorders * lifetime: bipolar disorder or psychotic disorder * psychotropic medications, aside from a short half-life sedative/hypnotic for insomnia, or a short half-life benzodiazepine as needed for anxiety but not exceeding a frequency of 3 doses in one week and not to be taken on the days of the training or MRI scan * current cognitive-behavioral therapy Exclusion criteria for all participants: * Neurological disorder * Pregnancy * Current major medical disorders that may affect cerebral metabolism such as diabetes or thyroid disorders * Current risk of suicide with a plan and intent * Ferromagnetic metal implantations or devices (electronic implants or devices, infusion pumps, aneurysm clips, metal fragments or foreign bodies, metal prostheses, joints, rods or plates) * Visual acuity worse than 20/35 for each eye as determined by Snellen close vision acuity chart (vision will be tested with corrective lenses if participant uses them).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre for Addiction and Mental Health
Toronto, Ontario, M6J 1H3, Canada
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