Psychiatric disorder

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This trial tests whether adding specially trained community health workers to routine mental health care helps people with serious mental illness quit smoking. Participants receive individualized counseling, education, and help with quit goals and medications. The study measures …

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This trial tests a 24-week virtual care program called BRIDGE NET for people with serious mental illness who are starting cancer treatment. The program brings together oncology and mental health teams to plan care, provide early psychiatric support, and regularly check in with pa…

This study tests whether a robotic surgical system can safely perform delicate microsurgery on deep lymph nodes in the neck of people with Alzheimer's disease. The idea is that improving lymph drainage from the brain might help clear harmful proteins linked to Alzheimer's. The tr…

This study tests whether MDMA, combined with a type of talk therapy called Acceptance and Commitment Therapy (ACT), can help treat post-traumatic stress disorder (PTSD) in military service members. Participants receive either a full or low dose of MDMA during therapy sessions. Th…

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This study tests whether a personalized program of exercise, diet, sleep support, social activities, and a weight-loss drug (semaglutide) can improve mental functioning in 140 adults with depression, bipolar disorder, or schizophrenia. Participants are randomly assigned to the pe…

This study looks at whether an online education and support program can help people with schizophrenia or bipolar disorder stick to their medication plans. Researchers will compare digital questionnaires with pharmacy records to measure adherence. About 1,640 adults in Spain will…

This study looks at whether extra education from a pharmacist can help people aged 18-60 who are starting a new antipsychotic medication for conditions like schizophrenia or bipolar disorder. The goal is to see if this support reduces weight gain and other metabolic side effects.…

Researchers are studying whether community health workers improve mental health among the Wayapi and Teko people in Camopi and Trois-Sauts, French Guiana. These communities face high rates of psychological distress and suicidal behavior. The study tracks suicidal thoughts and att…

This trial tests a support package for Ethiopian women who migrate to the Middle East for domestic work. The package includes peer support, a mobile app with educational materials, self-help groups, and counseling, aiming to improve their mental and sexual health. The study will …

This trial tests whether a collaborative psychological model—combining daily music listening, a smartphone app with AI chatbot support and mindfulness exercises, telephone check-ins, and wearable monitoring—can reduce the risk of postnatal depression and persistent pain after chi…

Researchers are testing CROSS-MIND, an eight-week school program where trained teachers lead weekly 90-minute storytelling and reflection sessions for students in grades 6 to 10 in Bharatpur, Nepal. Classes are randomly assigned to the program or to usual school activities, and a…

This trial tests whether a 4-week group therapy program can improve sleep in adults with chronic mental illness who also have insomnia. Participants attend weekly sessions focused on sleep habits, relaxation, and sleep-friendly routines, and track their sleep in a diary. The stud…

This study is testing a new group therapy program called CHANGE, designed for young adults aged 18-25 with psychiatric disorders. The program consists of 8 weekly sessions covering topics like transition to adulthood, suicidality, media addiction, and communication. The goal is t…

This study tests a telephone program where older adults in rural areas share life memories three times a week. Researchers want to see if it reduces loneliness and improves mental well-being, social support, and life satisfaction for both older adults and their informal caregiver…

This pilot study tests whether N-acetylcysteine (NAC), an antioxidant supplement, can reduce repetitive and self-injurious behaviors in people with Cornelia de Lange syndrome (CdLS). Ten participants aged 13–35 will receive both NAC and a placebo in random order over 18 weeks. Th…

This pilot study tests a new model of mental health support for siblings aged 10-17 of children with medical complexity. The model uses screening and assessments by social workers, who can provide talk therapy or refer to a child psychiatrist for diagnosis and treatment. The goal…

This trial tests whether Narrative Enhancement and Cognitive Therapy (NECT), a 12-session group program, can help adults with severe mental health disorders — including substance use disorders — overcome self-stigma and promote personal recovery. About 106 participants receiving …

This study tests whether a mobile-based rehabilitation program, built on the PERMA-H model of well-being, can improve hope, self-confidence, and social support in people recovering from a tracheostomy due to oral cancer. Participants use a WeChat mini-program with a chatbot and t…

This pilot study explores whether group workshops using MaKey MaKey and Scratch—tools that turn everyday objects into touchpads for creating music, games, and stories—can improve social participation, motivation, and empowerment in adults with mental health conditions. Twenty par…

This study tests whether 12 weekly Qi Gong sessions can reduce dissociative symptoms—like feeling disconnected from yourself or your surroundings—in adults who experienced childhood trauma. Ninety outpatients will be randomly assigned to either add Qi Gong to their usual care or …

This study tests whether short virtual reality nature sessions can lower stress for people admitted to an acute psychiatric ward. 120 adult patients will either receive standard care or add 10-15 minute VR nature experiences every other day. Researchers will measure changes in pe…

This study tests whether adding peer support specialists to emergency department teams can reduce the use of physical and chemical restraints for agitated patients. Researchers will compare restraint rates before and after the peer support program is introduced across several hos…

This study tests whether a combination of real-time brain training (using a wearable brain scanner called fNIRS) and personalized text messages can help women with bulimia nervosa improve self-control and reduce binge eating. Forty women aged 18-55 will receive either real or sha…

This study tests whether giving children nose drops of dexmedetomidine or esketamine before anesthesia can reduce negative behavior changes like anxiety, sleep problems, or irritability after day surgery. About 342 children aged 2 to 12 will be randomly assigned to receive one of…

This study is testing a new program to help adults with mental health problems become more active and connected. The program combines support from psychiatric care and community groups to encourage healthy habits and social activities. Researchers will see if it helps 60 particip…

This study tests an 8-week digital program that helps migrants in Sweden improve their mental health through better sleep, diet, physical activity, and social connections. 240 adults with moderate stress, anxiety, or depression will either get the program or a general wellness mo…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests whether a single 'Braining' group exercise session can quickly reduce anxiety in people receiving psychiatric care. Thirty participants will rate their anxiety before and after the session. The goal is to see if exercise can be a fast-acting tool to ease symptoms…

This study aims to see if peer support can help pregnant and postpartum veterans who have serious mental illness. Researchers will develop a program where trained peer specialists offer support, then test it with 24 veterans to see if it is helpful and practical. The goal is to i…

This study tests a 15-session group therapy program for people with schizophrenia who still hear voices despite medication. The program combines several proven strategies to help reduce how often the voices occur and how much distress they cause. Researchers will compare the ther…

This study tests a program that combines doctor care, digital tools, virtual reality, and school-based support to help teens and adults in Morocco with depression and anxiety. About 146 participants will be split into two groups: one gets the new program, the other gets usual car…

This study tests if adding exercise and education to standard talk therapy helps people with depression feel better. About 112 adults will be split into two groups: one gets therapy alone, the other adds an 8-week program of guided exercise and learning sessions. Researchers will…

This study will test if art therapy sessions can lower anxiety and disease severity in 48 adults hospitalized in a psychiatry ward. Participants will be randomly assigned to receive art therapy plus standard care or standard care alone. The goal is to see if creative expression c…

This study tests whether chewing gum can reduce excessive drooling caused by psychiatric medications. Researchers will compare 46 adults who chew gum as part of a swallowing program to those who don't. The goal is to find a simple, non-drug solution for this uncomfortable side ef…

This natural history study will explore how life experiences and environmental factors affect heart health and metabolism among 50 Bhutanese adults living in the US. Participants will complete a survey and discuss their views on providing biological samples. The goal is to identi…

Researchers at the University of Liverpool are exploring how different menu labels affect food choices and feelings in adults with eating disorders, common mental health conditions like anxiety or depression, and no mental health diagnosis. Participants order a meal from a simula…

This study asks 1,000 Flemish foster parents about the behavioral challenges of the children in their care, their own parenting style, and how satisfied they are with the foster care system. It also explores what extra support they need, such as help with difficult behavior or co…

This study follows 200 children and teens aged 7-17 who are at higher risk for depression, anxiety, or obsessive-compulsive disorder (OCD) due to family history or early symptoms. Over two years, researchers will use interviews, questionnaires, brain scans (EEG and MRI), and biol…

This study looks at the nutritional health of people aged 65 and older who are hospitalized with mental disorders. Researchers will assess conditions like malnutrition, frailty, and obesity, and use the findings to design a practical care pathway for nutritional support. The goal…

This study follows 2,000 adults with severe mental illness (such as schizophrenia, bipolar disorder, or severe depression) who are admitted to intensive care units (ICUs) in France. Researchers track their survival and other outcomes for up to 12 months to identify factors that p…

This study investigates whether sequencing the genomes of patients with early-onset or unusual psychiatric disorders—along with their biological parents—can uncover hidden genetic causes. Researchers aim to find disease-related gene variants in at least 12% of participants aged 3…

This study tests a new program called CapExchange, where people with stable mental health conditions exchange practical skills with others in their community. The goal is to see if this approach is practical and helpful for improving well-being and social connection. About 10 to …

This study looks at how environmental factors like heat, cold, and pollution affect wounds, mental health, and drug use in homeless people in Augsburg. Researchers will compare wound care from a mobile unit to a hospital clinic, and use saliva tests to check drug use. The goal is…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study tests a program to help mental health providers prescribe smoking cessation medications to veterans with serious mental illness. Researchers will work with 65 providers and veterans to see if the program is acceptable and practical. The goal is to overcome barriers tha…

This study looks at 125 hospitalized adults who have both a mental disorder and a substance use problem (dual diagnosis). Researchers want to see if things like social support and coping skills are linked to better treatment adherence and daily functioning. The goal is to find pr…

This study looks at a new program that helps children aged 6 to 18 with mild mental health issues get faster care by improving how doctors, nurses, and community providers work together. Researchers will interview healthcare professionals and families to find out what helps or hi…

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study looks at how people with a first episode of psychosis tell their life stories and whether that relates to their well-being and recovery. Researchers will compare 96 participants—those with early psychosis, those with chronic psychosis, and healthy controls—using questi…

This study looks at a program called Individual Placement and Support (IPS) that helps people with severe mental disorders find regular jobs. It compares IPS to the usual way of getting help from social workers. The goal is to see if IPS is worth the extra cost by measuring how m…