Myocardial infarction

Researchers compare two timing strategies for the Impella CP heart pump in people who have a heart attack and develop cardiogenic shock, a dangerous state where the heart cannot pump enough blood. One group receives the pump before the artery-opening procedure called PCI, while t…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

The RELEASE trial tests whether adults aged 65 and older with stable ischemic heart disease can safely stop their daily low-dose aspirin. Researchers will compare stopping aspirin against continuing it in 7,000 participants who have been free of heart events for at least two year…

This study tests whether using a drug-coated balloon during a procedure to open a blocked artery is better than medication alone for treating plaque erosions, a common cause of heart attacks. About 62 adults who have had a heart attack and have plaque erosion will be randomly ass…

This phase 2 trial tests whether a combined antioxidant therapy—ascorbate, N-acetylcysteine, and deferoxamine—can reduce heart muscle damage when given before and during angioplasty for a first anterior ST-elevation heart attack. Adults eligible for primary PCI will be randomly a…

This trial is testing the best timing for opening additional blocked arteries in people who have had a severe type of heart attack (STEMI) with multiple blocked vessels. After the main blocked artery is opened, participants are randomly assigned to have the other blockages treate…

This trial tests whether giving empagliflozin before or after a procedure to open a blocked heart artery (primary PCI) reduces heart muscle injury during a heart attack. Adults aged 18-75 of South Asian origin having their first heart attack will be randomly assigned to receive e…

This trial tests whether a virtual world-based cardiac rehabilitation program can improve heart health and participation compared to standard in-person rehab. The program, called Destination Cardiac Rehab, is a 3D interactive telehealth option that patients can use from home. Res…

This study tests whether a medicine given as a nose spray before a heart stent procedure can reduce heart muscle injury or heart attack. About 1800 adults scheduled for elective stent placement will receive either the medicine or a placebo spray. Researchers will measure heart da…

This trial tests whether a hybrid cardiac telerehabilitation program — combining in-person sessions, live video workouts, and remote monitoring — can improve adherence to exercise rehab in people with coronary artery disease or stable heart failure. Participants are randomly assi…

This study tests whether a 6-month program delivered through the Telegram messaging app can help people stop smoking after a heart attack. 142 adult smokers who use Telegram will either get the chatbot support or standard advice. The goal is to see if more people quit with the ch…

This trial tests whether adding eccentric cycling—a type of exercise where muscles lengthen under tension—to standard cardiac rehabilitation can improve recovery in people who have had a heart attack. Eccentric exercise may allow higher muscle loads with less cardiovascular deman…

This study tests whether giving high-risk heart attack patients personalized education before they leave the hospital can reduce their chances of being readmitted. The education covers disease management, medication adherence, lifestyle changes, and recognizing warning signs. Res…

This study looks at 240 adults having a major heart attack (STEMI) when the standard emergency procedure to open the blocked artery is expected to be delayed by over an hour. Half will get a clot-busting drug (tenecteplase) right away, followed by the procedure within 2-24 hours.…

This study looks at a special stent (a small mesh tube) coated with a drug called sirolimus, used to open blocked heart arteries. Researchers will follow 300 adults who received this stent during a standard heart procedure to see how safe and effective it is over 5 years. The mai…

This study tests whether a new wire-free imaging method called μFR can help doctors decide which blocked heart arteries need stents after a heart attack. About 350 patients with multiple blocked arteries will be randomly assigned to standard care or μFR-guided treatment. The goal…

This study tests a new radiation treatment for people with a life-threatening fast heart rhythm called ventricular tachycardia that hasn't been helped by medication or prior procedures. About 24 adults with an implanted defibrillator will receive a single, targeted dose of radiat…

This trial tests a hybrid exercise program (HyBEST) for people with coronary artery disease. It combines supervised sessions at a center with home workouts using a wearable tracker. The goal is to see if this approach improves exercise capacity, body composition, and quality of l…

This study tests a new treatment called MiSaver, made from umbilical cord blood cells, for people who recently had a heart attack. The goal is to see if it safely helps the heart pump better and reduces future heart problems. About 102 participants will either receive the cell tr…

This study tests whether a smartwatch, combined with artificial intelligence, can help monitor heart attack patients during their recovery at home. About 1,050 participants will either use the smartwatch with AI, a smartwatch without AI, or receive standard care. The goal is to s…

This study looks at two ways to treat people with a type of heart attack (NSTE-ACS) who have multiple blocked arteries. One group gets all blockages fixed during the same emergency procedure, while the other group fixes the main blockage first and the others later. The goal is to…

This study tests whether giving a powerful cholesterol-lowering drug (recaticimab) early after a heart attack can safely reduce future heart problems. About 2,442 adults who recently had a heart attack will receive the drug or standard care. The goal is to see if this approach lo…

This study tests a smartphone-based rehab program for young and middle-aged people (18-60) who had a heart attack. The program uses an app to guide exercise, diet, medication, and stress management, with support from a team of heart doctors, nurses, nutritionists, and psychologis…

This study tests whether a short course of the antibiotic rifaximin can improve how well the blood thinner ticagrelor works in people who have had a heart attack. The idea is that unhealthy gut bacteria may interfere with the drug, and clearing them out could help prevent future …

This study tests whether digital health tools can help people recover safely at home after a heart attack. Researchers will compare two types of follow-up care: education alone versus education plus extra support like symptom tracking and virtual appointments. The goal is to redu…

Researchers are studying whether the total time from heart attack symptom onset to balloon inflation during angioplasty helps predict contrast-induced nephropathy, a kidney complication that can occur after the procedure. The trial enrolls 400 adults with ST-segment elevation myo…

Researchers at Mayo Clinic are testing whether people who have a type 2 heart attack, without major blockages in the large heart arteries, are more likely to have disease in the tiny blood vessels of the heart. The study uses a special X-ray procedure called coronary reactivity t…

This trial compares two blood-test strategies for diagnosing heart attacks in people with chest pain: the standard approach of testing at arrival and again 3 hours later, versus an accelerated approach testing at arrival and again after just 1 hour. The goal is to see whether the…

This trial tests whether a smartphone app called Antshrike, paired with a smartwatch, can predict heart attacks or strokes within 3-4 days in people at high risk. Participants aged 40 to 79 with existing heart disease or elevated risk will wear the smartwatch for 18 months while …

This study will develop and test an artificial intelligence (AI) model to predict the risk of a heart attack within 6 months in people who have already had one. Researchers will combine different types of patient data to create a more accurate risk score. The goal is to identify …

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

This study tests whether adding cilostazol, a drug that improves blood flow, to standard aspirin or clopidogrel therapy can prevent another stroke or heart attack in people who have recently had a stroke or mini-stroke. About 2,000 participants will take either cilostazol or a pl…

This study tests a 13-week remote stress recovery program for people who had a heart attack before age 55 and still feel distressed. The program includes online sessions with a therapist, a workbook, and videos. The goal is to see if a larger trial is possible by checking how man…

This study looks at whether 12 virtual health coaching sessions over 16 weeks can help people with heart disease (like heart failure or a heart attack) improve their health, reduce stress, and lower the chance of going back to the hospital. About 70 adults will take part, and the…

This study tests if combining arm and leg cycling exercise is better than leg cycling alone for improving fitness and quality of life in people who have had a heart attack. Forty medically stable adults aged 40-70 will exercise three times a week for six weeks. Researchers will m…

This study tests whether a combination of a motivational phone call for patients and reminders for their doctors can increase attendance at cardiac rehabilitation after a type 2 heart attack. Researchers will compare 60 adults who receive this extra support to those who get usual…

This study will compare two types of aerobic exercise—interval training and continuous training—in 48 people with stable coronary artery disease. Participants will exercise twice a week for 8 weeks as part of a cardiac rehab program. Researchers will measure heart efficiency, exe…

This study looks at whether listening to music can help lower anxiety and improve sleep in people who have had a heart attack and are spending their first night in a special heart unit. About 64 adults will take part. They will listen to music and then use eye masks and earplugs …

This study looks at two simple methods to help local anesthesia work better for children aged 6-12 with a condition called Molar-Incisor Hypomineralization (MIH), which makes teeth sensitive and hard to numb. Researchers will apply either silver diamine fluoride or a cold pack to…

This study tests whether a home-based cardiac rehabilitation program can improve quality of life and health behaviors in heart patients living in low-resource settings in Pakistan. The program includes diet advice, exercise suggestions, medication reminders, and counseling, deliv…

This study investigates clonal hematopoiesis, an age-related condition where blood stem cells acquire mutations, and how it triggers inflammation linked to heart disease. Researchers will compare immune cells from healthy people, those with high-risk mutations, and patients with …

This study looks at whether a specific heart ultrasound measurement, called left atrial reservoir strain, can better predict serious heart problems within 6 months after a non-ST-elevation heart attack (NSTEMI). Researchers will measure this strain in 150 patients and compare its…

This study looks at how ready people are to make lifestyle changes after having a heart attack treated with a stent. Researchers will ask participants who had a heart attack in the past six months to fill out questionnaires about their habits, quality of life, and emotional well-…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will follow 400 people who had a heart attack and have moderately reduced heart function (ejection fraction 35-50%). Participants will get a small implantable heart monitor to track their heart rhythm for up to 5 years. The goal is to identify markers that could predic…

This study aims to see if wearable foot-pods (like Stryd) and breathing frequency monitors can accurately measure exercise intensity in people who have had a heart attack in the past 6 months. 24 participants will perform walking tests on flat ground and a treadmill while their o…

This study will create a digital twin of the heart for 1,000 people who have had a heart attack. The goal is to see if this computer model can better predict who is at risk for sudden cardiac death compared to the current standard method. Participants will undergo a cardiac CT sc…

This study will follow 1,800 people who had a stent placed in their heart arteries using a special camera (OCT). Researchers want to see if new measurements from routine angiograms can better predict future heart problems like heart attacks or chest pain. The goal is to improve h…

This observational study will enroll 20,000 Korean adults who have had a heart attack (acute myocardial infarction). Researchers will collect detailed data from hospitals nationwide to understand what factors affect long-term outcomes. The goal is to create better risk prediction…

This study develops and tests an AI system that reads de-identified patient admission notes to classify four types of coronary syndromes, including heart attacks and angina. The tool is designed to protect patient privacy while helping doctors diagnose more accurately and quickly…

This study is testing a new algorithm that helps paramedics decide if a patient with chest pain is having a heart attack. About 304 patients will get a quick blood test in the ambulance, and researchers will track their outcomes for 90 days. The goal is to fine-tune the algorithm…

This study will use data from over 10,000 people to create a risk prediction model for coronary artery disease. Researchers will combine heart imaging scans (like CT angiograms) with blood markers (like cholesterol) to better identify who is at high risk for heart attacks or othe…

This observational study will enroll 135 adults who had a severe type of heart attack (STEMI) and were treated with angioplasty. Researchers will use a special ultrasound technique to measure left atrium strain within 48 hours of admission. The goal is to see if this measurement …

This study will develop an artificial intelligence model that combines heart MRI scans and patient data to predict long-term risks after a heart attack. Researchers will enroll 800 patients who have had a severe type of heart attack (STEMI) and undergone emergency artery-opening …

This study will develop a new AI-powered model to predict major heart problems after a heart attack. Researchers will analyze data from over 1,500 patients who had a heart attack and received a stent. The goal is to create a more accurate tool than current methods to identify pat…

This study tests whether using very low radiation doses combined with special software can produce clear images of the heart's arteries. About 50 adults scheduled for a standard heart angiogram will have extra images taken with the new low-radiation method. The goal is to see if …

This study aims to create a risk prediction tool for ischemic stroke in people who have had a heart attack but do not have atrial fibrillation. Researchers will analyze the medical records of 4,000 past patients to see if common hospital data can accurately predict stroke risk du…